BRD-A01346607_FLUMETHASONE_HCC515_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

119 genes differentially expressed following the BRD-A01346607_FLUMETHASONE_HCC515_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL1 acyl-CoA synthetase long-chain family member 1
ALOX15B arachidonate 15-lipoxygenase, type B
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCL20 chemokine (C-C motif) ligand 20
CCND2 cyclin D2
CP ceruloplasmin (ferroxidase)
CPM carboxypeptidase M
CXCL13 chemokine (C-X-C motif) ligand 13
CYB5A cytochrome b5 type A (microsomal)
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DUSP1 dual specificity phosphatase 1
EFNA1 ephrin-A1
ENO1 enolase 1, (alpha)
FKBP5 FK506 binding protein 5
GLS glutaminase
GLUL glutamate-ammonia ligase
GSAP gamma-secretase activating protein
IL6R interleukin 6 receptor
LTA4H leukotriene A4 hydrolase
LTF lactotransferrin
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MAOA monoamine oxidase A
METTL7A methyltransferase like 7A
MPO myeloperoxidase
MPZL2 myelin protein zero-like 2
MUC1 mucin 1, cell surface associated
MYC v-myc avian myelocytomatosis viral oncogene homolog
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NNMT nicotinamide N-methyltransferase
ORM1 orosomucoid 1
POU2AF1 POU class 2 associating factor 1
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A8 S100 calcium binding protein A8
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFTPB surfactant protein B
SFTPC surfactant protein C
SMARCD2 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 2
SOD2 superoxide dismutase 2, mitochondrial
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TRIM22 tripartite motif containing 22
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein
ZBTB16 zinc finger and BTB domain containing 16
ZFP36 ZFP36 ring finger protein
ZNF589 zinc finger protein 589

decreased expression

Symbol Name
ANXA1 annexin A1
ARL4C ADP-ribosylation factor-like 4C
AXL AXL receptor tyrosine kinase
BASP1 brain abundant, membrane attached signal protein 1
BEX1 brain expressed, X-linked 1
BHLHE41 basic helix-loop-helix family, member e41
BTG3 BTG family, member 3
CADM1 cell adhesion molecule 1
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CLEC2B C-type lectin domain family 2, member B
COL4A2 collagen, type IV, alpha 2
COLEC12 collectin sub-family member 12
COTL1 coactosin-like F-actin binding protein 1
CRISP3 cysteine-rich secretory protein 3
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CYBRD1 cytochrome b reductase 1
DCK deoxycytidine kinase
DKK3 dickkopf WNT signaling pathway inhibitor 3
DLX2 distal-less homeobox 2
FLRT2 fibronectin leucine rich transmembrane protein 2
FSTL1 follistatin-like 1
GMPR guanosine monophosphate reductase
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GTSE1 G-2 and S-phase expressed 1
H1FX H1 histone family, member X
HAT1 histone acetyltransferase 1
HMG20B high mobility group 20B
HSPA1A heat shock 70kDa protein 1A
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IGFBP3 insulin-like growth factor binding protein 3
IGFBP6 insulin-like growth factor binding protein 6
LAPTM4B lysosomal protein transmembrane 4 beta
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
MATN2 matrilin 2
MDK midkine (neurite growth-promoting factor 2)
MOK MOK protein kinase
MYL9 myosin, light chain 9, regulatory
NLGN4X neuroligin 4, X-linked
NPTX2 neuronal pentraxin II
NTS neurotensin
PBX1 pre-B-cell leukemia homeobox 1
PBX3 pre-B-cell leukemia homeobox 3
PHLDA1 pleckstrin homology-like domain, family A, member 1
PNMA1 paraneoplastic Ma antigen 1
PRKCA protein kinase C, alpha
PSIP1 PC4 and SFRS1 interacting protein 1
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
PTX3 pentraxin 3, long
RHOC ras homolog family member C
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
SCGB2A1 secretoglobin, family 2A, member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SMAD3 SMAD family member 3
SPAG5 sperm associated antigen 5
SPINK4 serine peptidase inhibitor, Kazal type 4
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SQSTM1 sequestosome 1
STC1 stanniocalcin 1
SYNJ2 synaptojanin 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TGFBI transforming growth factor, beta-induced, 68kDa
TMSB15A thymosin beta 15a
TOX3 TOX high mobility group box family member 3
TPM1 tropomyosin 1 (alpha)
WT1 Wilms tumor 1