BRD-A01320529_salmeterol_VCAP_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

193 genes differentially expressed following the BRD-A01320529_salmeterol_VCAP_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3
ABHD4 abhydrolase domain containing 4
ACSL3 acyl-CoA synthetase long-chain family member 3
ACTN1 actinin, alpha 1
ADA adenosine deaminase
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AGR2 anterior gradient 2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDOB aldolase B, fructose-bisphosphate
ANKRD10 ankyrin repeat domain 10
ANPEP alanyl (membrane) aminopeptidase
APPBP2 amyloid beta precursor protein (cytoplasmic tail) binding protein 2
ARMCX3 armadillo repeat containing, X-linked 3
ASRGL1 asparaginase like 1
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BASP1 brain abundant, membrane attached signal protein 1
BIK BCL2-interacting killer (apoptosis-inducing)
C1ORF115 chromosome 1 open reading frame 115
CALD1 caldesmon 1
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CREM cAMP responsive element modulator
CSK c-src tyrosine kinase
CXCL13 chemokine (C-X-C motif) ligand 13
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
CYTH1 cytohesin 1
DCXR dicarbonyl/L-xylulose reductase
DDIT4 DNA-damage-inducible transcript 4
DLX2 distal-less homeobox 2
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNM1L dynamin 1-like
DST dystonin
DUSP10 dual specificity phosphatase 10
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EIF5A eukaryotic translation initiation factor 5A
ELOVL5 ELOVL fatty acid elongase 5
EZR ezrin
FERMT2 fermitin family member 2
FKBP5 FK506 binding protein 5
FOXO3 forkhead box O3
GATA3 GATA binding protein 3
GRB10 growth factor receptor-bound protein 10
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like
HSPA2 heat shock 70kDa protein 2
IDI1 isopentenyl-diphosphate delta isomerase 1
IL6ST interleukin 6 signal transducer
INPP1 inositol polyphosphate-1-phosphatase
INSIG1 insulin induced gene 1
ITGAV integrin, alpha V
JMJD6 jumonji domain containing 6
KAT6B K(lysine) acetyltransferase 6B
KCNK1 potassium channel, two pore domain subfamily K, member 1
KIAA1324 KIAA1324
KRT81 keratin 81, type II
LDLR low density lipoprotein receptor
LGMN legumain
LPXN leupaxin
LTF lactotransferrin
LXN latexin
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MALT1 MALT1 paracaspase
MAP7 microtubule-associated protein 7
MAPK1IP1L mitogen-activated protein kinase 1 interacting protein 1-like
MAPK6 mitogen-activated protein kinase 6
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MSMO1 methylsterol monooxygenase 1
MSX1 msh homeobox 1
MUC5B mucin 5B, oligomeric mucus/gel-forming
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NKX3-1 NK3 homeobox 1
NR4A3 nuclear receptor subfamily 4, group A, member 3
PALLD palladin, cytoskeletal associated protein
PCTP phosphatidylcholine transfer protein
PDE4B phosphodiesterase 4B, cAMP-specific
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PDLIM5 PDZ and LIM domain 5
PER1 period circadian clock 1
PIP4K2A phosphatidylinositol-5-phosphate 4-kinase, type II, alpha
PIR pirin (iron-binding nuclear protein)
PLAT plasminogen activator, tissue
PLIN2 perilipin 2
PRAME preferentially expressed antigen in melanoma
PSD3 pleckstrin and Sec7 domain containing 3
RANBP2 RAN binding protein 2
RAP1GAP RAP1 GTPase activating protein
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RCAN1 regulator of calcineurin 1
REG1A regenerating islet-derived 1 alpha
RGS2 regulator of G-protein signaling 2
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERTAD2 SERTA domain containing 2
SIK1 salt-inducible kinase 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SPDEF SAM pointed domain containing ETS transcription factor
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
STXBP6 syntaxin binding protein 6 (amisyn)
SYNM synemin, intermediate filament protein
TBX3 T-box 3
TFF1 trefoil factor 1
TGFBI transforming growth factor, beta-induced, 68kDa
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM100 transmembrane protein 100
TNC tenascin C
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TSKU tsukushi, small leucine rich proteoglycan
TSPYL2 TSPY-like 2
XBP1 X-box binding protein 1
XIST X inactive specific transcript (non-protein coding)
ZBTB10 zinc finger and BTB domain containing 10

decreased expression

Symbol Name
ADGRE5 adhesion G protein-coupled receptor E5
ADGRG6 adhesion G protein-coupled receptor G6
ADRB2 adrenoceptor beta 2, surface
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
ASPN asporin
BST2 bone marrow stromal cell antigen 2
C1ORF106 chromosome 1 open reading frame 106
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CCDC85B coiled-coil domain containing 85B
CCL5 chemokine (C-C motif) ligand 5
CD24 CD24 molecule
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CX3CR1 chemokine (C-X3-C motif) receptor 1
DIAPH2 diaphanous-related formin 2
DKK2 dickkopf WNT signaling pathway inhibitor 2
EDNRA endothelin receptor type A
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ENO1 enolase 1, (alpha)
ERLIN2 ER lipid raft associated 2
FAM129A family with sequence similarity 129, member A
FBL fibrillarin
GAS2 growth arrest-specific 2
GSTM3 glutathione S-transferase mu 3 (brain)
HLA-B major histocompatibility complex, class I, B
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HLA-G major histocompatibility complex, class I, G
HOPX HOP homeobox
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IFI16 interferon, gamma-inducible protein 16
IFI44L interferon-induced protein 44-like
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT3 interferon-induced protein with tetratricopeptide repeats 3
IGFBP3 insulin-like growth factor binding protein 3
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit)
LAMA4 laminin, alpha 4
LAMP5 lysosomal-associated membrane protein family, member 5
LGALS8 lectin, galactoside-binding, soluble, 8
LTB lymphotoxin beta (TNF superfamily, member 3)
MET MET proto-oncogene, receptor tyrosine kinase
MX1 MX dynamin-like GTPase 1
MX2 MX dynamin-like GTPase 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAP1L1 nucleosome assembly protein 1-like 1
NR2F1 nuclear receptor subfamily 2, group F, member 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
PDGFC platelet derived growth factor C
PLEKHJ1 pleckstrin homology domain containing, family J member 1
PLK2 polo-like kinase 2
PPT1 palmitoyl-protein thioesterase 1
PRR7 proline rich 7 (synaptic)
REXO2 RNA exonuclease 2
RGS4 regulator of G-protein signaling 4
RGS5 regulator of G-protein signaling 5
SNX10 sorting nexin 10
SOX11 SRY (sex determining region Y)-box 11
TAGLN2 transgelin 2
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM97 transmembrane protein 97
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13
TP53 tumor protein p53
TRIB1 tribbles pseudokinase 1
TSPAN4 tetraspanin 4
TSPAN8 tetraspanin 8
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
WNT5A wingless-type MMTV integration site family, member 5A