BRD-A01320529_Salmeterol_HCC515_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

75 genes differentially expressed following the BRD-A01320529_Salmeterol_HCC515_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAT2 acetyl-CoA acetyltransferase 2
ALDOC aldolase C, fructose-bisphosphate
ARG2 arginase 2
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CD24 CD24 molecule
CD9 CD9 molecule
CLCA4 chloride channel accessory 4
CXADR coxsackie virus and adenovirus receptor
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DHCR24 24-dehydrocholesterol reductase
EBP emopamil binding protein (sterol isomerase)
ENO1 enolase 1, (alpha)
FADS2 fatty acid desaturase 2
FBLN1 fibulin 1
FCGBP Fc fragment of IgG binding protein
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FGFR2 fibroblast growth factor receptor 2
GBE1 glucan (1,4-alpha-), branching enzyme 1
HIST1H2AC histone cluster 1, H2ac
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IDI1 isopentenyl-diphosphate delta isomerase 1
INSIG1 insulin induced gene 1
KRT15 keratin 15, type I
LDLR low density lipoprotein receptor
LPAR6 lysophosphatidic acid receptor 6
MAOA monoamine oxidase A
MPZL2 myelin protein zero-like 2
MSMO1 methylsterol monooxygenase 1
MTSS1 metastasis suppressor 1
NSDHL NAD(P) dependent steroid dehydrogenase-like
PEG10 paternally expressed 10
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PPAP2B phosphatidic acid phosphatase type 2B
RAB4A RAB4A, member RAS oncogene family
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGCC regulator of cell cycle
RND3 Rho family GTPase 3
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
S100A14 S100 calcium binding protein A14
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCPEP1 serine carboxypeptidase 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SQLE squalene epoxidase
SREBF2 sterol regulatory element binding transcription factor 2
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STX3 syntaxin 3
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TXNDC9 thioredoxin domain containing 9
UGDH UDP-glucose 6-dehydrogenase
VEGFA vascular endothelial growth factor A
WDR7 WD repeat domain 7

decreased expression

Symbol Name
ALOX5AP arachidonate 5-lipoxygenase-activating protein
COL5A1 collagen, type V, alpha 1
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
ELANE elastase, neutrophil expressed
G0S2 G0/G1 switch 2
GUSBP11 glucuronidase, beta pseudogene 11
HOXC6 homeobox C6
IGL immunoglobulin lambda locus
IL7R interleukin 7 receptor
ITM2A integral membrane protein 2A
KYNU kynureninase
NUDCD3 NudC domain containing 3
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
SRC SRC proto-oncogene, non-receptor tyrosine kinase
STUB1 STIP1 homology and U-box containing protein 1, E3 ubiquitin protein ligase
TRBC1 T cell receptor beta constant 1
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1