BRD-A00993607_Alprenolol hydrochloride_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

59 genes differentially expressed following the BRD-A00993607_Alprenolol hydrochloride_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ASS1 argininosuccinate synthase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHST2 carbohydrate (N-acetylglucosamine-6-O) sulfotransferase 2
CLDN3 claudin 3
EIF5B eukaryotic translation initiation factor 5B
FRZB frizzled-related protein
GAL galanin/GMAP prepropeptide
HEBP2 heme binding protein 2
MAN2A1 mannosidase, alpha, class 2A, member 1
NELL2 NEL-like 2 (chicken)
PDE8B phosphodiesterase 8B
TBC1D1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TYMP thymidine phosphorylase
VAMP8 vesicle-associated membrane protein 8

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ARMCX1 armadillo repeat containing, X-linked 1
ATF1 activating transcription factor 1
CAPN3 calpain 3, (p94)
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CNN3 calponin 3, acidic
CSTA cystatin A (stefin A)
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLD dihydrolipoamide dehydrogenase
EIF4A1 eukaryotic translation initiation factor 4A1
EPB41L2 erythrocyte membrane protein band 4.1-like 2
FADS1 fatty acid desaturase 1
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HPRT1 hypoxanthine phosphoribosyltransferase 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LHFP lipoma HMGIC fusion partner
LYPLA1 lysophospholipase I
MARCKS myristoylated alanine-rich protein kinase C substrate
MN1 meningioma (disrupted in balanced translocation) 1
MTUS1 microtubule associated tumor suppressor 1
MYH10 myosin, heavy chain 10, non-muscle
NRIP1 nuclear receptor interacting protein 1
OPN3 opsin 3
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PLLP plasmolipin
POLR2K polymerase (RNA) II (DNA directed) polypeptide K, 7.0kDa
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RBBP4 retinoblastoma binding protein 4
RDX radixin
THBS1 thrombospondin 1
TMEM255A transmembrane protein 255A
TNS1 tensin 1
TNS3 tensin 3
TOP2A topoisomerase (DNA) II alpha 170kDa
TRAM1 translocation associated membrane protein 1
TSPYL5 TSPY-like 5
UFM1 ubiquitin-fold modifier 1
WFDC2 WAP four-disulfide core domain 2
WSB1 WD repeat and SOCS box containing 1