BRD-A00758722_NORETHYNODREL_VCAP_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

278 genes differentially expressed following the BRD-A00758722_NORETHYNODREL_VCAP_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ACOT9 acyl-CoA thioesterase 9
ACSL3 acyl-CoA synthetase long-chain family member 3
ADA adenosine deaminase
ADM adrenomedullin
ANXA3 annexin A3
ANXA5 annexin A5
AREG amphiregulin
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18
ARMCX3 armadillo repeat containing, X-linked 3
ASPN asporin
ATF3 activating transcription factor 3
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BIK BCL2-interacting killer (apoptosis-inducing)
C6ORF62 chromosome 6 open reading frame 62
CARD10 caspase recruitment domain family, member 10
CD163 CD163 molecule
CD52 CD52 molecule
CD9 CD9 molecule
CD99 CD99 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CLIC3 chloride intracellular channel 3
CUX2 cut-like homeobox 2
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DAZAP2 DAZ associated protein 2
DDIT4 DNA-damage-inducible transcript 4
DSP desmoplakin
EGFR epidermal growth factor receptor
ELOVL5 ELOVL fatty acid elongase 5
F11R F11 receptor
F3 coagulation factor III (thromboplastin, tissue factor)
FABP4 fatty acid binding protein 4, adipocyte
FAM134B family with sequence similarity 134, member B
FAM189A2 family with sequence similarity 189, member A2
FHL1 four and a half LIM domains 1
FKBP1B FK506 binding protein 1B, 12.6 kDa
FN1 fibronectin 1
FNDC3B fibronectin type III domain containing 3B
FZD5 frizzled class receptor 5
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GJA1 gap junction protein, alpha 1, 43kDa
GLRX glutaredoxin (thioltransferase)
GLUL glutamate-ammonia ligase
GNMT glycine N-methyltransferase
GPER1 G protein-coupled estrogen receptor 1
GSTT2 glutathione S-transferase theta 2 (gene/pseudogene)
H1F0 H1 histone family, member 0
HGD homogentisate 1,2-dioxygenase
HOMER2 homer scaffolding protein 2
INPP1 inositol polyphosphate-1-phosphatase
IQGAP2 IQ motif containing GTPase activating protein 2
IRF7 interferon regulatory factor 7
IRS2 insulin receptor substrate 2
ISG20 interferon stimulated exonuclease gene 20kDa
JUNB jun B proto-oncogene
KIAA1324 KIAA1324
KLK11 kallikrein-related peptidase 11
KLK2 kallikrein-related peptidase 2
KRT18 keratin 18, type I
LDLR low density lipoprotein receptor
LEPROT leptin receptor overlapping transcript
LGMN legumain
LIMK2 LIM domain kinase 2
LINC00341 long intergenic non-protein coding RNA 341
LOX lysyl oxidase
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MATN2 matrilin 2
MFAP5 microfibrillar associated protein 5
MME membrane metallo-endopeptidase
MN1 meningioma (disrupted in balanced translocation) 1
MSMB microseminoprotein, beta-
MT1M metallothionein 1M
MXRA7 matrix-remodelling associated 7
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NCF2 neutrophil cytosolic factor 2
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
NKX3-1 NK3 homeobox 1
NLRP2 NLR family, pyrin domain containing 2
NUCB2 nucleobindin 2
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha
PLSCR3 phospholipid scramblase 3
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
RAP1GAP RAP1 GTPase activating protein
REEP5 receptor accessory protein 5
RHOBTB3 Rho-related BTB domain containing 3
SAT1 spermidine/spermine N1-acetyltransferase 1
SC5D sterol-C5-desaturase
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCP2 sterol carrier protein 2
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)
SEC62 SEC62 homolog (S. cerevisiae)
SERINC3 serine incorporator 3
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3
SHANK2 SH3 and multiple ankyrin repeat domains 2
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC35E3 solute carrier family 35, member E3
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SOAT1 sterol O-acyltransferase 1
SOCS2 suppressor of cytokine signaling 2
SPDEF SAM pointed domain containing ETS transcription factor
SPINT1 serine peptidase inhibitor, Kunitz type 1
SST somatostatin
STXBP2 syntaxin binding protein 2
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TIMP3 TIMP metallopeptidase inhibitor 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNS3 tensin 3
TP53I3 tumor protein p53 inducible protein 3
TPP1 tripeptidyl peptidase I
WIPI1 WD repeat domain, phosphoinositide interacting 1
XBP1 X-box binding protein 1
ZFP36 ZFP36 ring finger protein
ZFP36L2 ZFP36 ring finger protein-like 2

decreased expression

Symbol Name
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
BARD1 BRCA1 associated RING domain 1
BIRC5 baculoviral IAP repeat containing 5
BOP1 block of proliferation 1
BRCA1 breast cancer 1, early onset
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
BUB3 BUB3 mitotic checkpoint protein
CA12 carbonic anhydrase XII
CACYBP calcyclin binding protein
CCDC85B coiled-coil domain containing 85B
CCL19 chemokine (C-C motif) ligand 19
CCL21 chemokine (C-C motif) ligand 21
CCNA2 cyclin A2
CCNF cyclin F
CD3EAP CD3e molecule, epsilon associated protein
CDC20 cell division cycle 20
CDC25A cell division cycle 25A
CDC7 cell division cycle 7
CDCA4 cell division cycle associated 4
CDCA8 cell division cycle associated 8
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CENPF centromere protein F, 350/400kDa
CENPU centromere protein U
CKS2 CDC28 protein kinase regulatory subunit 2
CLU clusterin
CPSF1 cleavage and polyadenylation specific factor 1, 160kDa
CTPS1 CTP synthase 1
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL14 chemokine (C-X-C motif) ligand 14
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
EIF4B eukaryotic translation initiation factor 4B
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific )
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPN2 epsin 2
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
EXO1 exonuclease 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
F12 coagulation factor XII (Hageman factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FANCG Fanconi anemia, complementation group G
FANCI Fanconi anemia, complementation group I
FAS Fas cell surface death receptor
FBL fibrillarin
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GINS2 GINS complex subunit 2 (Psf2 homolog)
GNG12 guanine nucleotide binding protein (G protein), gamma 12
GRSF1 G-rich RNA sequence binding factor 1
H2AFZ H2A histone family, member Z
H3F3B H3 histone, family 3B (H3.3B)
HELLS helicase, lymphoid-specific
HES1 hes family bHLH transcription factor 1
HJURP Holliday junction recognition protein
HMGB2 high mobility group box 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
HN1 hematological and neurological expressed 1
HOPX HOP homeobox
HPRT1 hypoxanthine phosphoribosyltransferase 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
IGFBP3 insulin-like growth factor binding protein 3
IGFBP4 insulin-like growth factor binding protein 4
IGFBP7 insulin-like growth factor binding protein 7
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
ITGB3BP integrin beta 3 binding protein (beta3-endonexin)
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KIF15 kinesin family member 15
KIF18B kinesin family member 18B
KIF20A kinesin family member 20A
KIF2C kinesin family member 2C
LAMP5 lysosomal-associated membrane protein family, member 5
LDHB lactate dehydrogenase B
LGALS4 lectin, galactoside-binding, soluble, 4
LIG1 ligase I, DNA, ATP-dependent
LRP8 low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
LSM3 LSM3 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LSM4 LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MARCKS myristoylated alanine-rich protein kinase C substrate
MCM2 minichromosome maintenance complex component 2
MCM6 minichromosome maintenance complex component 6
MELK maternal embryonic leucine zipper kinase
MET MET proto-oncogene, receptor tyrosine kinase
MKI67 marker of proliferation Ki-67
MTA1 metastasis associated 1
MYC v-myc avian myelocytomatosis viral oncogene homolog
NAP1L1 nucleosome assembly protein 1-like 1
NHP2 NHP2 ribonucleoprotein
NME1 NME/NM23 nucleoside diphosphate kinase 1
NOLC1 nucleolar and coiled-body phosphoprotein 1
NOP56 NOP56 ribonucleoprotein
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin)
NPY1R neuropeptide Y receptor Y1
NR2F1 nuclear receptor subfamily 2, group F, member 1
NT5DC2 5'-nucleotidase domain containing 2
NUP210 nucleoporin 210kDa
NUSAP1 nucleolar and spindle associated protein 1
OXCT1 3-oxoacid CoA transferase 1
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PARP2 poly (ADP-ribose) polymerase 2
PCNA proliferating cell nuclear antigen
PCYOX1L prenylcysteine oxidase 1 like
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PEBP1 phosphatidylethanolamine binding protein 1
PLA2G16 phospholipase A2, group XVI
PLK1 polo-like kinase 1
PLK2 polo-like kinase 2
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR1E polymerase (RNA) I polypeptide E, 53kDa
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa
PPAT phosphoribosyl pyrophosphate amidotransferase
PRC1 protein regulator of cytokinesis 1
PRPS2 phosphoribosyl pyrophosphate synthetase 2
PRR7 proline rich 7 (synaptic)
PTTG1 pituitary tumor-transforming 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RFC5 replication factor C (activator 1) 5, 36.5kDa
RGS2 regulator of G-protein signaling 2
RNASEH2A ribonuclease H2, subunit A
RPL14 ribosomal protein L14
RRM1 ribonucleotide reductase M1
RRP1B ribosomal RNA processing 1B
RUVBL2 RuvB-like AAA ATPase 2
SIGMAR1 sigma non-opioid intracellular receptor 1
SLIRP SRA stem-loop interacting RNA binding protein
SNRPD2 small nuclear ribonucleoprotein D2 polypeptide 16.5kDa
SPAG5 sperm associated antigen 5
ST7 suppression of tumorigenicity 7
STEAP1 six transmembrane epithelial antigen of the prostate 1
STOML2 stomatin (EPB72)-like 2
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
TACC3 transforming, acidic coiled-coil containing protein 3
TARBP1 TAR (HIV-1) RNA binding protein 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TM4SF1 transmembrane 4 L six family member 1
TMEM109 transmembrane protein 109
TMEM97 transmembrane protein 97
TOP2A topoisomerase (DNA) II alpha 170kDa
TP53 tumor protein p53
TPX2 TPX2, microtubule-associated
TRIP13 thyroid hormone receptor interactor 13
TRIP6 thyroid hormone receptor interactor 6
TROAP trophinin associated protein
TXN thioredoxin
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
UBE2S ubiquitin-conjugating enzyme E2S
UGCG UDP-glucose ceramide glucosyltransferase
USP13 ubiquitin specific peptidase 13 (isopeptidase T-3)
VCAM1 vascular cell adhesion molecule 1
WNT5A wingless-type MMTV integration site family, member 5A
YBX3 Y box binding protein 3