BRD-A00420644_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

159 genes differentially expressed following the BRD-A00420644_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ACTN1 actinin, alpha 1
ADM adrenomedullin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMOTL2 angiomotin like 2
ANXA1 annexin A1
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BRD4 bromodomain containing 4
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CFD complement factor D (adipsin)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
DUSP1 dual specificity phosphatase 1
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
EPAS1 endothelial PAS domain protein 1
EPHA2 EPH receptor A2
F2RL1 coagulation factor II (thrombin) receptor-like 1
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
FSCN1 fascin actin-bundling protein 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GCLM glutamate-cysteine ligase, modifier subunit
GEM GTP binding protein overexpressed in skeletal muscle
GLUL glutamate-ammonia ligase
GPNMB glycoprotein (transmembrane) nmb
GPX2 glutathione peroxidase 2
GRB10 growth factor receptor-bound protein 10
HBEGF heparin-binding EGF-like growth factor
HMOX1 heme oxygenase 1
HOPX HOP homeobox
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER5 immediate early response 5
IL1R2 interleukin 1 receptor, type II
JAG1 jagged 1
JUN jun proto-oncogene
KLF4 Kruppel-like factor 4 (gut)
KLF5 Kruppel-like factor 5 (intestinal)
KLF6 Kruppel-like factor 6
KLF7 Kruppel-like factor 7 (ubiquitous)
KLF9 Kruppel-like factor 9
KLHL21 kelch-like family member 21
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LYZ lysozyme
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
MAP2K3 mitogen-activated protein kinase kinase 3
MIR22HG MIR22 host gene
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1X metallothionein 1X
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NT5E 5'-nucleotidase, ecto (CD73)
PALLD palladin, cytoskeletal associated protein
PDLIM1 PDZ and LIM domain 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R15A protein phosphatase 1, regulatory subunit 15A
RAP1GAP RAP1 GTPase activating protein
RND3 Rho family GTPase 3
S100A2 S100 calcium binding protein A2
S100P S100 calcium binding protein P
SAT1 spermidine/spermine N1-acetyltransferase 1
SDC4 syndecan 4
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERTAD2 SERTA domain containing 2
SFN stratifin
SMAD3 SMAD family member 3
SNAI2 snail family zinc finger 2
SOX9 SRY (sex determining region Y)-box 9
SQSTM1 sequestosome 1
SRGN serglycin
TES testin LIM domain protein
TGFA transforming growth factor, alpha
THBD thrombomodulin
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TRIB1 tribbles pseudokinase 1
TRIM29 tripartite motif containing 29
TXNRD1 thioredoxin reductase 1
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
ZNF91 zinc finger protein 91
ZYX zyxin

decreased expression

Symbol Name
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ARMT1 acidic residue methyltransferase 1
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ASRGL1 asparaginase like 1
BASP1 brain abundant, membrane attached signal protein 1
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CA12 carbonic anhydrase XII
CCNA2 cyclin A2
CDC25A cell division cycle 25A
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CENPA centromere protein A
CEP55 centrosomal protein 55kDa
CP ceruloplasmin (ferroxidase)
CTSH cathepsin H
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ELOVL5 ELOVL fatty acid elongase 5
ERBB3 erb-b2 receptor tyrosine kinase 3
ESR1 estrogen receptor 1
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GPC4 glypican 4
HADH hydroxyacyl-CoA dehydrogenase
HEXIM1 hexamethylene bis-acetamide inducible 1
HOXD1 homeobox D1
HSPA8 heat shock 70kDa protein 8
KIF11 kinesin family member 11
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KIF23 kinesin family member 23
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MKI67 marker of proliferation Ki-67
MUC1 mucin 1, cell surface associated
NPY1R neuropeptide Y receptor Y1
NREP neuronal regeneration related protein
NUP210 nucleoporin 210kDa
OLFM1 olfactomedin 1
PBK PDZ binding kinase
PEG10 paternally expressed 10
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PSIP1 PC4 and SFRS1 interacting protein 1
PTP4A2 protein tyrosine phosphatase type IVA, member 2
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RRM2 ribonucleotide reductase M2
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SELT selenoprotein T
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SSR1 signal sequence receptor, alpha
SYNE2 spectrin repeat containing, nuclear envelope 2
TMX1 thioredoxin-related transmembrane protein 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TOP2A topoisomerase (DNA) II alpha 170kDa
TSPAN13 tetraspanin 13
TSPYL5 TSPY-like 5
TUBB tubulin, beta class I
VCAN versican
XBP1 X-box binding protein 1
XPO1 exportin 1