BRD-A00420644_-666_HCC515_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

121 genes differentially expressed following the BRD-A00420644_-666_HCC515_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAMDEC1 ADAM-like, decysin 1
ADM adrenomedullin
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANPEP alanyl (membrane) aminopeptidase
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
BAD BCL2-associated agonist of cell death
BTG3 BTG family, member 3
C1ORF116 chromosome 1 open reading frame 116
CA1 carbonic anhydrase I
CA2 carbonic anhydrase II
CD40 CD40 molecule, TNF receptor superfamily member 5
CD52 CD52 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
CXCL8 chemokine (C-X-C motif) ligand 8
CYTIP cytohesin 1 interacting protein
DARS aspartyl-tRNA synthetase
DDIT3 DNA-damage-inducible transcript 3
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DKK3 dickkopf WNT signaling pathway inhibitor 3
FAM69A family with sequence similarity 69, member A
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGFR2 fibroblast growth factor receptor 2
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
FST follistatin
FTH1 ferritin, heavy polypeptide 1
GADD45A growth arrest and DNA-damage-inducible, alpha
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HOXD1 homeobox D1
HYOU1 hypoxia up-regulated 1
ISG20 interferon stimulated exonuclease gene 20kDa
JCHAIN joining chain of multimeric IgA and IgM
KAT2B K(lysine) acetyltransferase 2B
KLF2 Kruppel-like factor 2
LAMP3 lysosomal-associated membrane protein 3
LYZ lysozyme
MIR22HG MIR22 host gene
MME membrane metallo-endopeptidase
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MTSS1 metastasis suppressor 1
NQO1 NAD(P)H dehydrogenase, quinone 1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NT5E 5'-nucleotidase, ecto (CD73)
ODC1 ornithine decarboxylase 1
PDE4B phosphodiesterase 4B, cAMP-specific
PHLDA2 pleckstrin homology-like domain, family A, member 2
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RBBP8 retinoblastoma binding protein 8
RGCC regulator of cell cycle
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SIK1 salt-inducible kinase 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRC SRC proto-oncogene, non-receptor tyrosine kinase
TBX3 T-box 3
TGFA transforming growth factor, alpha
THBS1 thrombospondin 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNIP1 TNFAIP3 interacting protein 1
TRIB3 tribbles pseudokinase 3
TUBB2A tubulin, beta 2A class IIa

decreased expression

Symbol Name
AGR2 anterior gradient 2
ALDH3B2 aldehyde dehydrogenase 3 family, member B2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
APOD apolipoprotein D
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
C1QB complement component 1, q subcomponent, B chain
CALML5 calmodulin-like 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CELF2 CUGBP, Elav-like family member 2
CLDN3 claudin 3
CLU clusterin
CNPY3 canopy FGF signaling regulator 3
CTTN cortactin
DPYSL2 dihydropyrimidinase-like 2
FADD Fas (TNFRSF6)-associated via death domain
FCGR1B Fc fragment of IgG, high affinity Ib, receptor (CD64)
GRAMD4 GRAM domain containing 4
HOXC6 homeobox C6
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
JARID2 jumonji, AT rich interactive domain 2
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MGP matrix Gla protein
MKL2 MKL/myocardin-like 2
NR2F2 nuclear receptor subfamily 2, group F, member 2
OSBPL8 oxysterol binding protein-like 8
PLP2 proteolipid protein 2 (colonic epithelium-enriched)
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1
PRKCB protein kinase C, beta
PROS1 protein S (alpha)
RBPJ recombination signal binding protein for immunoglobulin kappa J region
RGS4 regulator of G-protein signaling 4
RNF167 ring finger protein 167
SCGB2A2 secretoglobin, family 2A, member 2
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLPI secretory leukocyte peptidase inhibitor
SPDEF SAM pointed domain containing ETS transcription factor
STAB1 stabilin 1
STAT1 signal transducer and activator of transcription 1, 91kDa
STOM stomatin
STX1A syntaxin 1A (brain)
TBCB tubulin folding cofactor B
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFF3 trefoil factor 3 (intestinal)
THAP11 THAP domain containing 11
TLR4 toll-like receptor 4
TUBB tubulin, beta class I
VDAC1 voltage-dependent anion channel 1