BRD-A00420644_-666_A549_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

180 genes differentially expressed following the BRD-A00420644_-666_A549_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ACAT1 acetyl-CoA acetyltransferase 1
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
ARG2 arginase 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARMCX1 armadillo repeat containing, X-linked 1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
CA2 carbonic anhydrase II
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CELF2 CUGBP, Elav-like family member 2
CLCA4 chloride channel accessory 4
CYTIP cytohesin 1 interacting protein
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DLD dihydrolipoamide dehydrogenase
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EMP1 epithelial membrane protein 1
ERBB4 erb-b2 receptor tyrosine kinase 4
FHL1 four and a half LIM domains 1
FHL2 four and a half LIM domains 2
FKBP11 FK506 binding protein 11, 19 kDa
FOSL1 FOS-like antigen 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GPM6B glycoprotein M6B
GRIA2 glutamate receptor, ionotropic, AMPA 2
HBEGF heparin-binding EGF-like growth factor
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HLA-DPB1 major histocompatibility complex, class II, DP beta 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HSPA13 heat shock protein 70kDa family, member 13
IGFBP6 insulin-like growth factor binding protein 6
INHBA inhibin, beta A
INPP1 inositol polyphosphate-1-phosphatase
KLF4 Kruppel-like factor 4 (gut)
KLF9 Kruppel-like factor 9
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAOA monoamine oxidase A
MICALL1 MICAL-like 1
MME membrane metallo-endopeptidase
PDE4DIP phosphodiesterase 4D interacting protein
PENK proenkephalin
PHGDH phosphoglycerate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPAP2B phosphatidic acid phosphatase type 2B
PSAT1 phosphoserine aminotransferase 1
PYGB phosphorylase, glycogen; brain
RND3 Rho family GTPase 3
S100A14 S100 calcium binding protein A14
S100B S100 calcium binding protein B
SCRG1 stimulator of chondrogenesis 1
SCUBE2 signal peptide, CUB domain, EGF-like 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFN stratifin
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
STC2 stanniocalcin 2
STK39 serine threonine kinase 39
TICAM1 toll-like receptor adaptor molecule 1
TMPRSS2 transmembrane protease, serine 2
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TPD52L1 tumor protein D52-like 1
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TST thiosulfate sulfurtransferase (rhodanese)
UPP1 uridine phosphorylase 1
WARS tryptophanyl-tRNA synthetase
XBP1 X-box binding protein 1

decreased expression

Symbol Name
ADGRG2 adhesion G protein-coupled receptor G2
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALOX5 arachidonate 5-lipoxygenase
ASCL1 achaete-scute family bHLH transcription factor 1
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKB aurora kinase B
BANF1 barrier to autointegration factor 1
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CCNA2 cyclin A2
CCNB2 cyclin B2
CCNF cyclin F
CD24 CD24 molecule
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CDK1 cyclin-dependent kinase 1
CDKN3 cyclin-dependent kinase inhibitor 3
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CEP55 centrosomal protein 55kDa
CILP cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
COL5A2 collagen, type V, alpha 2
CP ceruloplasmin (ferroxidase)
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CRYZ crystallin, zeta (quinone reductase)
CYB5A cytochrome b5 type A (microsomal)
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
EMP2 epithelial membrane protein 2
FAM13A family with sequence similarity 13, member A
FBXO21 F-box protein 21
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GPX3 glutathione peroxidase 3
GSTA1 glutathione S-transferase alpha 1
GTSE1 G-2 and S-phase expressed 1
H2BFS H2B histone family, member S (pseudogene)
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HMMR hyaluronan-mediated motility receptor (RHAMM)
HOPX HOP homeobox
HSPA1A heat shock 70kDa protein 1A
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
KIF11 kinesin family member 11
KIF20A kinesin family member 20A
LBH limb bud and heart development
LBR lamin B receptor
LOC100505650 uncharacterized LOC100505650
LPCAT1 lysophosphatidylcholine acyltransferase 1
LYPD1 LY6/PLAUR domain containing 1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAGEA3 melanoma antigen family A3
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
METTL7A methyltransferase like 7A
NCAPG non-SMC condensin I complex, subunit G
NDC80 NDC80 kinetochore complex component
NR2F1 nuclear receptor subfamily 2, group F, member 1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NTS neurotensin
NUSAP1 nucleolar and spindle associated protein 1
PBK PDZ binding kinase
PCSK1 proprotein convertase subtilisin/kexin type 1
PEG10 paternally expressed 10
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POP5 processing of precursor 5, ribonuclease P/MRP subunit (S. cerevisiae)
PTTG1 pituitary tumor-transforming 1
QPRT quinolinate phosphoribosyltransferase
RBP1 retinol binding protein 1, cellular
RNF167 ring finger protein 167
RRM2 ribonucleotide reductase M2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SPAG5 sperm associated antigen 5
SST somatostatin
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
STMN1 stathmin 1
STX1A syntaxin 1A (brain)
TAGLN transgelin
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TM4SF1 transmembrane 4 L six family member 1
TMEM14A transmembrane protein 14A
TMPO thymopoietin
TNS3 tensin 3
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIB2 tribbles pseudokinase 2
TUBB tubulin, beta class I
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
VAMP8 vesicle-associated membrane protein 8
WWTR1 WW domain containing transcription regulator 1