BRD-A00420644_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

53 genes differentially expressed following the BRD-A00420644_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADRB2 adrenoceptor beta 2, surface
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
CCND2 cyclin D2
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLDN1 claudin 1
CMTM6 CKLF-like MARVEL transmembrane domain containing 6
CTH cystathionine gamma-lyase
CXADR coxsackie virus and adenovirus receptor
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DUSP1 dual specificity phosphatase 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM134B family with sequence similarity 134, member B
FAM46A family with sequence similarity 46, member A
FAS Fas cell surface death receptor
FHL2 four and a half LIM domains 2
GADD45A growth arrest and DNA-damage-inducible, alpha
GDF15 growth differentiation factor 15
HBB hemoglobin, beta
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
LARP6 La ribonucleoprotein domain family, member 6
LOC100505650 uncharacterized LOC100505650
MMP7 matrix metallopeptidase 7
MT1F metallothionein 1F
MYO1B myosin IB
PSAT1 phosphoserine aminotransferase 1
RCAN1 regulator of calcineurin 1
SLC38A2 solute carrier family 38, member 2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
TACSTD2 tumor-associated calcium signal transducer 2
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TRIB3 tribbles pseudokinase 3
TXNRD1 thioredoxin reductase 1
XBP1 X-box binding protein 1

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
ANPEP alanyl (membrane) aminopeptidase
BAMBI BMP and activin membrane-bound inhibitor
BST2 bone marrow stromal cell antigen 2
CALM1 calmodulin 1 (phosphorylase kinase, delta)
MDK midkine (neurite growth-promoting factor 2)
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PSRC1 proline/serine-rich coiled-coil 1
RBP1 retinol binding protein 1, cellular
SEPP1 selenoprotein P, plasma, 1
SLC25A24 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24
SORL1 sortilin-related receptor, L(DLR class) A repeats containing