Asthma Gene Set

Dataset dbGAP Gene-Trait Associations
Category disease or phenotype associations
Type trait
Description A bronchial disease that is characterized by chronic inflammation and narrowing of the airways, which is caused by a combination of environmental and genetic factors. The disease has_symptom recurring periods of wheezing (a whistling sound while breathing), has_symptom chest tightness, has_symptom shortness of breath, has_symptom mucus production and has_symptom coughing. The symptoms appear due to a variety of triggers such as allergens, irritants, respiratory infections, weather changes, exercise, stress, reflux disease, medications, foods and emotional anxiety. (Human Disease Ontology, DOID_2841)
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Genes

107 genes associated with the trait Asthma in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.

Symbol Name Standardized Value
NOTCH4 notch 4 1.49716
GSDMB gasdermin B 1.26538
IL1RL1 interleukin 1 receptor-like 1 1.21571
PBX2 pre-B-cell leukemia homeobox 2 1.21571
C6ORF10 chromosome 6 open reading frame 10 1.20587
CRB1 crumbs family member 1, photoreceptor morphogenesis associated 1.11353
SLC30A8 solute carrier family 30 (zinc transporter), member 8 1.09046
CDK2 cyclin-dependent kinase 2 0.944178
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1 0.922056
HLA-DPB1 major histocompatibility complex, class II, DP beta 1 0.922056
IL18R1 interleukin 18 receptor 1 0.820059
SMAD3 SMAD family member 3 0.807263
PYHIN1 pyrin and HIN domain family, member 1 0.807263
GSDMA gasdermin A 0.796965
IL2RB interleukin 2 receptor, beta 0.763999
IL6R interleukin 6 receptor 0.731179
PDE4D phosphodiesterase 4D, cAMP-specific 0.711358
TUSC3 tumor suppressor candidate 3 0.685324
GAB1 GRB2-associated binding protein 1 0.667558
IL13 interleukin 13 0.64828
RORA RAR-related orphan receptor A 0.64828
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5 0.609816
RAD50 RAD50 homolog (S. cerevisiae) 0.585749
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.581148
PRKG1 protein kinase, cGMP-dependent, type I 0.552134
RPS28P1 ribosomal protein S28 pseudogene 1 0.539181
SVEP1 sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1 0.527821
TAF7 TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa 0.50084
PCDH15 protocadherin-related 15 0.50084
AKAP6 A kinase (PRKA) anchor protein 6 0.446581
ATP11AUN ATP11A upstream neighbor 0.444195
PLXNA4 plexin A4 0.443956
NOS2 nitric oxide synthase 2, inducible 0.438439
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3 0.406869
CCDC67 coiled-coil domain containing 67 0.378873
ANK1 ankyrin 1, erythrocytic 0.356676
CTNNA3 catenin (cadherin-associated protein), alpha 3 0.33862
CDH23 cadherin-related 23 0.33862
PDE9A phosphodiesterase 9A 0.33862
C10ORF54 chromosome 10 open reading frame 54 0.33862
CTNND2 catenin (cadherin-associated protein), delta 2 0.33862
G2E3 G2/M-phase specific E3 ubiquitin protein ligase 0.338563
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 0.323533
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 0.323533
PRKCE protein kinase C, epsilon 0.323533
MAVS mitochondrial antiviral signaling protein 0.310838
CSMD1 CUB and Sushi multiple domains 1 0.29992
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 0.29992
KANK1 KN motif and ankyrin repeat domains 1 0.29992
CNTLN centlein, centrosomal protein 0.29992
ZMYND8 zinc finger, MYND-type containing 8 0.295627
FAM196B family with sequence similarity 196, member B 0.281822
DOCK2 dedicator of cytokinesis 2 0.281822
NRDE2 NRDE-2, necessary for RNA interference, domain containing 0.275245
SYNPR synaptoporin 0.27422
IL1RL2 interleukin 1 receptor-like 2 0.2597
GLIS3 GLIS family zinc finger 3 0.254293
PTPRD protein tyrosine phosphatase, receptor type, D 0.240131
TNIP1 TNFAIP3 interacting protein 1 0.239948
RAB39A RAB39A, member RAS oncogene family 0.237447
FSTL4 follistatin-like 4 0.201427
PARVB parvin, beta 0.188268
ZNF585B zinc finger protein 585B 0.187017
TMEM132D transmembrane protein 132D 0.185859
PAX3 paired box 3 0.184031
CPNE4 copine IV 0.178409
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.174347
LRRC4C leucine rich repeat containing 4C 0.166982
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39) 0.164001
FSIP1 fibrous sheath interacting protein 1 0.163714
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 0.16082
ADGRB3 adhesion G protein-coupled receptor B3 0.157919
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2 0.154311
ZNF423 zinc finger protein 423 0.152972
ADORA1 adenosine A1 receptor 0.152895
POLI polymerase (DNA directed) iota 0.145438
NR1D1 nuclear receptor subfamily 1, group D, member 1 0.140051
NRG3 neuregulin 3 0.13128
PINX1 PIN2/TERF1 interacting, telomerase inhibitor 1 0.128323
TMCO4 transmembrane and coiled-coil domains 4 0.123077
SCNN1A sodium channel, non voltage gated 1 alpha subunit 0.12113
BEST1 bestrophin 1 0.115367
MTUS2 microtubule associated tumor suppressor candidate 2 0.107545
CGN cingulin 0.104017
GSTA4 glutathione S-transferase alpha 4 0.10384
DPY19L1P1 DPY19L1 pseudogene 1 0.103132
LBH limb bud and heart development 0.101497
CACUL1 CDK2-associated, cullin domain 1 0.100621
HS3ST4 heparan sulfate (glucosamine) 3-O-sulfotransferase 4 0.099862
LAMA1 laminin, alpha 1 0.099379
PKP1 plakophilin 1 0.093803
SLC25A21 solute carrier family 25 (mitochondrial oxoadipate carrier), member 21 0.090338
THBS4 thrombospondin 4 0.089726
EYA2 EYA transcriptional coactivator and phosphatase 2 0.087521
CREB5 cAMP responsive element binding protein 5 0.086983
ADCY2 adenylate cyclase 2 (brain) 0.086208
CCDC140 coiled-coil domain containing 140 0.08243
OR4K13 olfactory receptor, family 4, subfamily K, member 13 0.080809
TMEM161B transmembrane protein 161B 0.07697
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.07594
HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 0.075029
TMEM62 transmembrane protein 62 0.074539
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta 0.072962
NPAS3 neuronal PAS domain protein 3 0.070194
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.063346
NAV2 neuron navigator 2 0.061534
MAPK10 mitogen-activated protein kinase 10 0.060188