Aortic Diseases Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D001018
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Genes

234 genes/proteins associated with the disease Aortic Diseases from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
MMP2 matrix metallopeptidase 2 2.88009
MMP9 matrix metallopeptidase 9 2.88009
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 1.82359
COL1A1 collagen, type I, alpha 1 1.80868
FAS Fas cell surface death receptor 1.78397
TGFB1 transforming growth factor, beta 1 1.74963
BCL2 B-cell CLL/lymphoma 2 1.74119
TNF tumor necrosis factor 1.71214
TP53 tumor protein p53 1.70865
BAX BCL2-associated X protein 1.69617
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 1.67998
EDN1 endothelin 1 1.6759
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.6662
KLF4 Kruppel-like factor 4 (gut) 1.6662
CCL2 chemokine (C-C motif) ligand 2 1.66598
CRP C-reactive protein, pentraxin-related 1.63116
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.62176
CAT catalase 1.61248
IL6 interleukin 6 1.60477
NOS2 nitric oxide synthase 2, inducible 1.6043
IFNG interferon, gamma 1.59497
CASP9 caspase 9, apoptosis-related cysteine peptidase 1.58467
FOS FBJ murine osteosarcoma viral oncogene homolog 1.57546
CTSB cathepsin B 1.5641
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 1.55772
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.55059
EGFR epidermal growth factor receptor 1.54451
NOS3 nitric oxide synthase 3 (endothelial cell) 1.54451
IL1B interleukin 1, beta 1.54086
VEGFA vascular endothelial growth factor A 1.52743
JUN jun proto-oncogene 1.52693
MAPK3 mitogen-activated protein kinase 3 1.52161
MAPK1 mitogen-activated protein kinase 1 1.51355
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 1.50549
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.50223
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.48813
RB1 retinoblastoma 1 1.48736
TFRC transferrin receptor 1.48608
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.47915
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1 1.47426
DDIT3 DNA-damage-inducible transcript 3 1.443
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 1.44029
FN1 fibronectin 1 1.43591
IGF1R insulin-like growth factor 1 receptor 1.42183
HMOX1 heme oxygenase 1 1.41478
CCND1 cyclin D1 1.41424
SOD2 superoxide dismutase 2, mitochondrial 1.4098
NR4A1 nuclear receptor subfamily 4, group A, member 1 1.39813
IL10 interleukin 10 1.3793
HSPE1 heat shock 10kDa protein 1 1.37705
BGLAP bone gamma-carboxyglutamate (gla) protein 1.37132
CTSH cathepsin H 1.35991
ACKR3 atypical chemokine receptor 3 1.35647
APP amyloid beta (A4) precursor protein 1.35357
MCL1 myeloid cell leukemia 1 1.35328
EDNRA endothelin receptor type A 1.35328
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 1.34983
EGR1 early growth response 1 1.34518
CDK4 cyclin-dependent kinase 4 1.33731
PPARG peroxisome proliferator-activated receptor gamma 1.33553
LPL lipoprotein lipase 1.33523
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 1.33523
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 1.33081
BID BH3 interacting domain death agonist 1.3228
CHEK2 checkpoint kinase 2 1.30911
TGFB2 transforming growth factor, beta 2 1.30758
ATF3 activating transcription factor 3 1.30421
CXCR4 chemokine (C-X-C motif) receptor 4 1.29564
XBP1 X-box binding protein 1 1.2944
GSR glutathione reductase 1.2941
SOX4 SRY (sex determining region Y)-box 4 1.29103
PARP1 poly (ADP-ribose) polymerase 1 1.2898
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 1.28579
S100A10 S100 calcium binding protein A10 1.28364
CD44 CD44 molecule (Indian blood group) 1.27997
FYN FYN proto-oncogene, Src family tyrosine kinase 1.27905
CDC25A cell division cycle 25A 1.27193
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 1.2707
EZR ezrin 1.26947
CALM1 calmodulin 1 (phosphorylase kinase, delta) 1.26514
BCL2L1 BCL2-like 1 1.2639
ADAM19 ADAM metallopeptidase domain 19 1.26298
SOD1 superoxide dismutase 1, soluble 1.26205
TPP2 tripeptidyl peptidase II 1.25868
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase) 1.25838
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 1.25745
GSTP1 glutathione S-transferase pi 1 1.25557
RAF1 Raf-1 proto-oncogene, serine/threonine kinase 1.25276
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 1.24843
ICAM1 intercellular adhesion molecule 1 1.24812
CCNG2 cyclin G2 1.2456
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 1.24181
SH3KBP1 SH3-domain kinase binding protein 1 1.23743
HDAC1 histone deacetylase 1 1.23743
VCAM1 vascular cell adhesion molecule 1 1.23712
CXCL8 chemokine (C-X-C motif) ligand 8 1.2368
MAP2K1 mitogen-activated protein kinase kinase 1 1.23456
MGP matrix Gla protein 1.22979
NRP1 neuropilin 1 1.22566
HDAC3 histone deacetylase 3 1.22566
PON1 paraoxonase 1 1.22436
PLAT plasminogen activator, tissue 1.22436
CD4 CD4 molecule 1.22177
CASP8 caspase 8, apoptosis-related cysteine peptidase 1.21855
NPPA natriuretic peptide A 1.21631
CLU clusterin 1.21631
ALOX12 arachidonate 12-lipoxygenase 1.21435
FASLG Fas ligand (TNF superfamily, member 6) 1.21402
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.21304
PBX1 pre-B-cell leukemia homeobox 1 1.21076
SREBF1 sterol regulatory element binding transcription factor 1 1.20978
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 1.20328
IGF1 insulin-like growth factor 1 (somatomedin C) 1.19509
TH tyrosine hydroxylase 1.19379
FASN fatty acid synthase 1.19379
HDAC2 histone deacetylase 2 1.19345
CASP2 caspase 2, apoptosis-related cysteine peptidase 1.19113
RGS2 regulator of G-protein signaling 2 1.18424
LDHA lactate dehydrogenase A 1.18424
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 1.17959
GPX2 glutathione peroxidase 2 1.17794
THBS1 thrombospondin 1 1.17629
APOB apolipoprotein B 1.17
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 1.17
DUSP6 dual specificity phosphatase 6 1.17
MAP2K2 mitogen-activated protein kinase kinase 2 1.167
GEM GTP binding protein overexpressed in skeletal muscle 1.16203
CYR61 cysteine-rich, angiogenic inducer, 61 1.16203
TXNIP thioredoxin interacting protein 1.1607
GPX3 glutathione peroxidase 3 1.15324
EDNRB endothelin receptor type B 1.1529
BDNF brain-derived neurotrophic factor 1.15223
MAOA monoamine oxidase A 1.14885
GPX1 glutathione peroxidase 1 1.14575
CCL5 chemokine (C-C motif) ligand 5 1.14302
E2F1 E2F transcription factor 1 1.13724
BTG2 BTG family, member 2 1.13313
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.13177
POU5F1 POU class 5 homeobox 1 1.13177
LEP leptin 1.13007
CD40LG CD40 ligand 1.12973
ATM ATM serine/threonine kinase 1.12906
GATA6 GATA binding protein 6 1.12703
CD14 CD14 molecule 1.12634
SPP1 secreted phosphoprotein 1 1.12599
TIMP1 TIMP metallopeptidase inhibitor 1 1.1253
FABP4 fatty acid binding protein 4, adipocyte 1.12254
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 1.1198
EFNB3 ephrin-B3 1.11809
SCD stearoyl-CoA desaturase (delta-9-desaturase) 1.11707
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 1.11501
CP ceruloplasmin (ferroxidase) 1.11186
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 1.11116
CASP1 caspase 1, apoptosis-related cysteine peptidase 1.11081
GFAP glial fibrillary acidic protein 1.10803
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.10803
ACIN1 apoptotic chromatin condensation inducer 1 1.10699
NFE2L2 nuclear factor, erythroid 2-like 2 1.10665
GSTA4 glutathione S-transferase alpha 4 1.10459
REN renin 1.10353
CD9 CD9 molecule 1.10317
NOS1 nitric oxide synthase 1 (neuronal) 1.10211
FCHSD2 FCH and double SH3 domains 2 1.10175
PTHLH parathyroid hormone-like hormone 1.1014
ATF6 activating transcription factor 6 1.10104
CCNB1 cyclin B1 1.09927
BCL2A1 BCL2-related protein A1 1.09646
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 1.08975
PRKCA protein kinase C, alpha 1.08726
SEC14L1 SEC14-like 1 (S. cerevisiae) 1.08726
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 1.08726
FAM20C family with sequence similarity 20, member C 1.08655
MSH2 mutS homolog 2 1.08584
CYCS cytochrome c, somatic 1.08584
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit 1.08549
ITGB3 integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) 1.08196
PCNA proliferating cell nuclear antigen 1.08055
MYH7 myosin, heavy chain 7, cardiac muscle, beta 1.07983
MKI67 marker of proliferation Ki-67 1.07947
IRX3 iroquois homeobox 3 1.07732
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 1.07625
MMP1 matrix metallopeptidase 1 1.07589
CD36 CD36 molecule (thrombospondin receptor) 1.07269
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 1.07128
CDC25B cell division cycle 25B 1.07093
H2AFX H2A histone family, member X 1.07022
G6PD glucose-6-phosphate dehydrogenase 1.06952
PLK2 polo-like kinase 2 1.06917
IL1A interleukin 1, alpha 1.06917
NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 1.06844
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 1.06808
BECN1 beclin 1, autophagy related 1.06333
GSN gelsolin 1.06297
VIM vimentin 1.06261
IL2RA interleukin 2 receptor, alpha 1.06152
FGF2 fibroblast growth factor 2 (basic) 1.06152
MAPK7 mitogen-activated protein kinase 7 1.05972
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 1.05936
HRAS Harvey rat sarcoma viral oncogene homolog 1.05828
MPO myeloperoxidase 1.05648
NOX4 NADPH oxidase 4 1.05573
HINT1 histidine triad nucleotide binding protein 1 1.05573
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 1.05573
MCM2 minichromosome maintenance complex component 2 1.05349
UBE2C ubiquitin-conjugating enzyme E2C 1.05349
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa 1.05015
ADIPOQ adiponectin, C1Q and collagen domain containing 1.04978
EEF2 eukaryotic translation elongation factor 2 1.04794
MAP1LC3A microtubule-associated protein 1 light chain 3 alpha 1.04684
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 1.04276
CASP4 caspase 4, apoptosis-related cysteine peptidase 1.04088
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 1.04088
CASP12 caspase 12 (gene/pseudogene) 1.03901
DTYMK deoxythymidylate kinase (thymidylate kinase) 1.03864
TRIB2 tribbles pseudokinase 2 1.03493
SRSF3 serine/arginine-rich splicing factor 3 1.03456
NFE2L1 nuclear factor, erythroid 2-like 1 1.03084
XRCC6 X-ray repair complementing defective repair in Chinese hamster cells 6 1.03084
IGFBP5 insulin-like growth factor binding protein 5 1.02821
PRNP prion protein 1.02671
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 1.02373
LGALS8 lectin, galactoside-binding, soluble, 8 1.02336
PRL prolactin 1.02188
PTH1R parathyroid hormone 1 receptor 1.02114
EIF3B eukaryotic translation initiation factor 3, subunit B 1.01701
DRD2 dopamine receptor D2 1.01625
HTRA2 HtrA serine peptidase 2 1.01625
TPP1 tripeptidyl peptidase I 1.01625
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 1.01512
CSNK2A2 casein kinase 2, alpha prime polypeptide 1.01324
CDK2 cyclin-dependent kinase 2 1.01324
PRKCB protein kinase C, beta 1.01062
IL12B interleukin 12B 1.01062
COL4A2 collagen, type IV, alpha 2 1.01025