Alzheimer Disease Gene Set

Dataset dbGAP Gene-Trait Associations
Category disease or phenotype associations
Type trait
Description A tauopathy that results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid. It is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability. (Human Disease Ontology, DOID_10652)
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Genes

80 genes associated with the trait Alzheimer Disease in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.

Symbol Name Standardized Value
TOMM40 translocase of outer mitochondrial membrane 40 homolog (yeast) 2.9448
APOC1 apolipoprotein C-I 1.85253
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7 1.28701
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A 1.16559
CR1 complement component (3b/4b) receptor 1 (Knops blood group) 1.15135
PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B) 1.14197
GAB2 GRB2-associated binding protein 2 0.944178
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.922056
CLU clusterin 0.866561
CD33 CD33 molecule 0.836775
CD2AP CD2-associated protein 0.769036
ZNF292 zinc finger protein 292 0.711358
PCDH11X protocadherin 11 X-linked 0.609816
F13A1 coagulation factor XIII, A1 polypeptide 0.585749
DCHS2 dachsous cadherin-related 2 0.552134
VSNL1 visinin-like 1 0.539181
BIN1 bridging integrator 1 0.50084
APOE apolipoprotein E 0.50084
CCDC134 coiled-coil domain containing 134 0.50084
SLC44A5 solute carrier family 44, member 5 0.443956
MPP7 membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7) 0.443956
NCR2 natural cytotoxicity triggering receptor 2 0.443956
DNAH11 dynein, axonemal, heavy chain 11 0.443956
ADCY8 adenylate cyclase 8 (brain) 0.443956
SLC4A1AP solute carrier family 4 (anion exchanger), member 1, adaptor protein 0.443956
RORA RAR-related orphan receptor A 0.406869
CUBN cubilin (intrinsic factor-cobalamin receptor) 0.406869
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 0.406869
EML1 echinoderm microtubule associated protein like 1 0.385324
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.383332
STK24 serine/threonine kinase 24 0.378873
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1 0.372231
PAK2 p21 protein (Cdc42/Rac)-activated kinase 2 0.356676
ZNF320 zinc finger protein 320 0.356676
POLN polymerase (DNA directed) nu 0.33862
CLVS1 clavesin 1 0.33862
GFRA2 GDNF family receptor alpha 2 0.323533
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) 0.323533
MGST3 microsomal glutathione S-transferase 3 0.323533
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.310838
STK11 serine/threonine kinase 11 0.310838
NME9 NME/NM23 family member 9 0.310838
NCAM1 neural cell adhesion molecule 1 0.29992
DISC1 disrupted in schizophrenia 1 0.29992
UTS2B urotensin 2B 0.29992
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.29992
CNTNAP2 contactin associated protein-like 2 0.29992
SLC28A1 solute carrier family 28 (concentrative nucleoside transporter), member 1 0.29992
ENSAP3 endosulfine alpha pseudogene 3 0.259947
WBSCR17 Williams-Beuren syndrome chromosome region 17 0.251738
LRRC39 leucine rich repeat containing 39 0.22961
AEN apoptosis enhancing nuclease 0.211881
DBT dihydrolipoamide branched chain transacylase E2 0.207088
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 0.206991
RYR2 ryanodine receptor 2 (cardiac) 0.205553
TENM4 teneurin transmembrane protein 4 0.200132
TRMT13 tRNA methyltransferase 13 homolog (S. cerevisiae) 0.135402
ANK1 ankyrin 1, erythrocytic 0.098753
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.094766
NDP Norrie disease (pseudoglioma) 0.092686
DIAPH3 diaphanous-related formin 3 0.073066
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.068416
NHSL1 NHS-like 1 0.063948
HIAT1 hippocampus abundant transcript 1 0.056721
COL22A1 collagen, type XXII, alpha 1 0.03922
CADPS Ca++-dependent secretion activator 0.036846
ARHGAP18 Rho GTPase activating protein 18 0.034783
BRMS1L breast cancer metastasis-suppressor 1-like 0.033219
PIEZO2 piezo-type mechanosensitive ion channel component 2 0.033037
RTN1 reticulon 1 0.027394
FBLN2 fibulin 2 0.027124
OSBPL10 oxysterol binding protein-like 10 0.026073
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 0.025893
DAB1 Dab, reelin signal transducer, homolog 1 (Drosophila) 0.025355
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.022899
NPAS3 neuronal PAS domain protein 3 0.022166
DGKH diacylglycerol kinase, eta 0.021891
ATXN1 ataxin 1 0.021556
C1ORF168 chromosome 1 open reading frame 168 0.021469
ERBB4 erb-b2 receptor tyrosine kinase 4 0.020724