Alzheimer Disease Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A tauopathy that results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid. It is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability. (Human Disease Ontology, DOID_10652)
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D000544
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Genes

722 genes/proteins associated with the disease Alzheimer Disease from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa 2.88009
PICALM phosphatidylinositol binding clathrin assembly protein 2.88009
EPHA1 EPH receptor A1 2.88009
BAX BCL2-associated X protein 2.88009
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase 2.88009
PRNP prion protein 2.88009
HMOX1 heme oxygenase 1 2.88009
BLMH bleomycin hydrolase 2.88009
CYP46A1 cytochrome P450, family 46, subfamily A, polypeptide 1 2.88009
ACHE acetylcholinesterase (Yt blood group) 2.88009
GSK3B glycogen synthase kinase 3 beta 2.88009
TFAM transcription factor A, mitochondrial 2.88009
TPI1 triosephosphate isomerase 1 2.88009
CD33 CD33 molecule 2.88009
PSEN1 presenilin 1 2.88009
PSEN2 presenilin 2 2.88009
CLU clusterin 2.88009
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A 2.88009
TF transferrin 2.88009
TREM2 triggering receptor expressed on myeloid cells 2 2.88009
NOS3 nitric oxide synthase 3 (endothelial cell) 2.88009
ACE angiotensin I converting enzyme 2.88009
CST3 cystatin C 2.88009
MAPT microtubule-associated protein tau 2.88009
TNF tumor necrosis factor 2.88009
IGF1R insulin-like growth factor 1 receptor 2.88009
PCDH11X protocadherin 11 X-linked 2.88009
ESR1 estrogen receptor 1 2.88009
A2M alpha-2-macroglobulin 2.88009
IL1B interleukin 1, beta 2.88009
IDE insulin-degrading enzyme 2.88009
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 2.88009
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 2.88009
NCSTN nicastrin 2.88009
PLAU plasminogen activator, urokinase 2.88009
APOE apolipoprotein E 2.88009
DHCR24 24-dehydrocholesterol reductase 2.88009
ATP5A1 ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle 2.88009
CHRNA7 cholinergic receptor, nicotinic, alpha 7 (neuronal) 2.88009
BIN1 bridging integrator 1 2.88009
RELN reelin 2.88009
GAPDHS glyceraldehyde-3-phosphate dehydrogenase, spermatogenic 2.88009
APP amyloid beta (A4) precursor protein 2.88009
IGF1 insulin-like growth factor 1 (somatomedin C) 2.88009
SOD2 superoxide dismutase 2, mitochondrial 2.88009
PPARG peroxisome proliferator-activated receptor gamma 2.88009
IGF2 insulin-like growth factor 2 2.88009
CRH corticotropin releasing hormone 2.88009
F2 coagulation factor II (thrombin) 2.88009
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 2.88009
CASP3 caspase 3, apoptosis-related cysteine peptidase 2.88009
PAXIP1 PAX interacting (with transcription-activation domain) protein 1 2.88009
PYY peptide YY 2.88009
BACE1 beta-site APP-cleaving enzyme 1 2.88009
MPO myeloperoxidase 2.88009
DPYSL2 dihydropyrimidinase-like 2 2.88009
CR1 complement component (3b/4b) receptor 1 (Knops blood group) 2.88009
BCHE butyrylcholinesterase 2.88009
MIR146A microRNA 146a 2.88009
SLC30A6 solute carrier family 30 (zinc transporter), member 6 2.88009
SLC30A4 solute carrier family 30 (zinc transporter), member 4 2.88009
CD2AP CD2-associated protein 2.88009
AD10 Alzheimer disease-10 2.88009
IGF2R insulin-like growth factor 2 receptor 2.88009
ARC activity-regulated cytoskeleton-associated protein 2.88009
CALM1 calmodulin 1 (phosphorylase kinase, delta) 2.88009
INS insulin 2.88009
ENO1 enolase 1, (alpha) 2.88009
BDNF brain-derived neurotrophic factor 2.88009
BCL2 B-cell CLL/lymphoma 2 2.88009
HFE hemochromatosis 2.88009
NPY neuropeptide Y 2.88009
AD5 Alzheimer disease 5 2.88009
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal) 2.88009
LEP leptin 2.88009
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6 2.88009
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7 2.88009
AD8 Alzheimer disease 8 2.88009
AD9 Alzheimer disease 9 2.88009
AD6 Alzheimer disease 6 2.88009
VEGFA vascular endothelial growth factor A 2.88009
TPP1 tripeptidyl peptidase I 2.88009
NOS2 nitric oxide synthase 2, inducible 2.36579
MAPK3 mitogen-activated protein kinase 3 2.23559
JUN jun proto-oncogene 2.21891
TP53 tumor protein p53 2.21086
CAT catalase 2.2062
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 2.19109
MAPK1 mitogen-activated protein kinase 1 2.17561
MAPK8 mitogen-activated protein kinase 8 2.15256
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 2.12968
FOS FBJ murine osteosarcoma viral oncogene homolog 2.12773
CXCL8 chemokine (C-X-C motif) ligand 8 2.114
MMP2 matrix metallopeptidase 2 2.09429
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 2.08858
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 2.06574
IL6 interleukin 6 2.01526
TGFB1 transforming growth factor, beta 1 2.00912
CASP7 caspase 7, apoptosis-related cysteine peptidase 1.98467
PPARA peroxisome proliferator-activated receptor alpha 1.98068
ICAM1 intercellular adhesion molecule 1 1.97757
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.97097
CCND1 cyclin D1 1.96551
IL2 interleukin 2 1.95934
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 1.95827
SNCA synuclein, alpha (non A4 component of amyloid precursor) 1.9554
SOD1 superoxide dismutase 1, soluble 1.95072
MMP9 matrix metallopeptidase 9 1.94343
LDLR low density lipoprotein receptor 1.94171
DDIT3 DNA-damage-inducible transcript 3 1.93475
CCL2 chemokine (C-C motif) ligand 2 1.92785
GCLC glutamate-cysteine ligase, catalytic subunit 1.92595
IFNG interferon, gamma 1.92172
MMP1 matrix metallopeptidase 1 1.92026
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.91519
MAPK9 mitogen-activated protein kinase 9 1.90574
TFRC transferrin receptor 1.89439
IL10 interleukin 10 1.89311
CASP8 caspase 8, apoptosis-related cysteine peptidase 1.8877
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 1.8716
NFE2L2 nuclear factor, erythroid 2-like 2 1.86515
EGR1 early growth response 1 1.86515
MMP3 matrix metallopeptidase 3 1.86167
GPX1 glutathione peroxidase 1 1.85869
EDN1 endothelin 1 1.84693
GSR glutathione reductase 1.84481
VCAM1 vascular cell adhesion molecule 1 1.84305
GCLM glutamate-cysteine ligase, modifier subunit 1.83378
NOS1 nitric oxide synthase 1 (neuronal) 1.83325
SIRT1 sirtuin 1 1.82272
HSPA1A heat shock 70kDa protein 1A 1.80491
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 1.80491
CREB1 cAMP responsive element binding protein 1 1.80077
FASLG Fas ligand (TNF superfamily, member 6) 1.77024
GSTA4 glutathione S-transferase alpha 4 1.76849
XBP1 X-box binding protein 1 1.74842
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.74641
BCL2L1 BCL2-like 1 1.7418
SRC SRC proto-oncogene, non-receptor tyrosine kinase 1.74039
FASN fatty acid synthase 1.73938
ALB albumin 1.73211
THBS1 thrombospondin 1 1.72947
CCL5 chemokine (C-C motif) ligand 5 1.72884
ACTA2 actin, alpha 2, smooth muscle, aorta 1.72199
CD36 CD36 molecule (thrombospondin receptor) 1.71891
BID BH3 interacting domain death agonist 1.71891
BAD BCL2-associated agonist of cell death 1.71358
CYP1A2 cytochrome P450, family 1, subfamily A, polypeptide 2 1.70553
CASP1 caspase 1, apoptosis-related cysteine peptidase 1.70491
CASP9 caspase 9, apoptosis-related cysteine peptidase 1.70491
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 1.70224
CEBPB CCAAT/enhancer binding protein (C/EBP), beta 1.69318
NR4A1 nuclear receptor subfamily 4, group A, member 1 1.68932
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 1.68825
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.68253
NCF1 neutrophil cytosolic factor 1 1.68041
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 1.67311
PDGFRB platelet-derived growth factor receptor, beta polypeptide 1.67137
TH tyrosine hydroxylase 1.66835
MAP2K1 mitogen-activated protein kinase kinase 1 1.65731
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 1.65555
CAV1 caveolin 1, caveolae protein, 22kDa 1.65424
CD44 CD44 molecule (Indian blood group) 1.65
TIMP2 TIMP metallopeptidase inhibitor 2 1.64573
CYP2E1 cytochrome P450, family 2, subfamily E, polypeptide 1 1.64506
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 1.6419
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 1.63966
CXCL2 chemokine (C-X-C motif) ligand 2 1.63518
SPP1 secreted phosphoprotein 1 1.6325
EGFR epidermal growth factor receptor 1.62335
IL12B interleukin 12B 1.6199
ATF3 activating transcription factor 3 1.61828
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 1.61828
FAS Fas cell surface death receptor 1.61413
IL1A interleukin 1, alpha 1.60921
DUSP1 dual specificity phosphatase 1 1.60454
MAP3K5 mitogen-activated protein kinase kinase kinase 5 1.59451
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 1.59172
ATP5B ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide 1.59125
COL1A1 collagen, type I, alpha 1 1.58631
PARP1 poly (ADP-ribose) polymerase 1 1.58374
LHB luteinizing hormone beta polypeptide 1.58303
RB1 retinoblastoma 1 1.57759
MKI67 marker of proliferation Ki-67 1.57665
SLC22A2 solute carrier family 22 (organic cation transporter), member 2 1.57042
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) 1.57018
CCL3 chemokine (C-C motif) ligand 3 1.56533
GAPDH glyceraldehyde-3-phosphate dehydrogenase 1.56361
FABP4 fatty acid binding protein 4, adipocyte 1.56312
PLAT plasminogen activator, tissue 1.5619
TIMP1 TIMP metallopeptidase inhibitor 1 1.55772
PCNA proliferating cell nuclear antigen 1.55747
BIRC5 baculoviral IAP repeat containing 5 1.54937
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein 1.54427
TXN thioredoxin 1.54427
MAPK14 mitogen-activated protein kinase 14 1.54038
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1 1.53941
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 1.53699
BGLAP bone gamma-carboxyglutamate (gla) protein 1.52938
ADIPOQ adiponectin, C1Q and collagen domain containing 1.5284
CASP4 caspase 4, apoptosis-related cysteine peptidase 1.52667
ALOX5 arachidonate 5-lipoxygenase 1.52616
EDNRB endothelin receptor type B 1.52515
HSPD1 heat shock 60kDa protein 1 (chaperonin) 1.52011
BIRC3 baculoviral IAP repeat containing 3 1.51607
CCNB1 cyclin B1 1.51506
HSPB1 heat shock 27kDa protein 1 1.50979
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) 1.50751
ERN1 endoplasmic reticulum to nucleus signaling 1 1.50423
F3 coagulation factor III (thromboplastin, tissue factor) 1.50423
CREBBP CREB binding protein 1.50146
SP1 Sp1 transcription factor 1.49304
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 1.49071
ATM ATM serine/threonine kinase 1.48659
JUNB jun B proto-oncogene 1.48402
RUNX2 runt-related transcription factor 2 1.48273
CD14 CD14 molecule 1.48222
APOA1 apolipoprotein A-I 1.47838
IL18 interleukin 18 1.47838
G6PD glucose-6-phosphate dehydrogenase 1.4766
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 1.47504
TLR4 toll-like receptor 4 1.47322
TXNRD1 thioredoxin reductase 1 1.47296
EPO erythropoietin 1.47244
STAT1 signal transducer and activator of transcription 1, 91kDa 1.46961
ADM adrenomedullin 1.46754
NQO1 NAD(P)H dehydrogenase, quinone 1 1.46674
VIM vimentin 1.46595
CXCL12 chemokine (C-X-C motif) ligand 12 1.46304
LCAT lecithin-cholesterol acyltransferase 1.46304
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 1.46304
FN1 fibronectin 1 1.46225
ANXA5 annexin A5 1.46225
FOXO1 forkhead box O1 1.46225
GADD45A growth arrest and DNA-damage-inducible, alpha 1.46067
PRKCD protein kinase C, delta 1.45883
CP ceruloplasmin (ferroxidase) 1.45883
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 1.45484
B2M beta-2-microglobulin 1.45299
NOX4 NADPH oxidase 4 1.45299
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase 1.45009
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 1.44653
TXNIP thioredoxin interacting protein 1.4449
ELK1 ELK1, member of ETS oncogene family 1.44355
ZFP36 ZFP36 ring finger protein 1.44084
PGK1 phosphoglycerate kinase 1 1.43782
F2R coagulation factor II (thrombin) receptor 1.43184
STC2 stanniocalcin 2 1.42859
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 1.42831
BAK1 BCL2-antagonist/killer 1 1.42804
CASP12 caspase 12 (gene/pseudogene) 1.42616
MAOA monoamine oxidase A 1.42562
SELE selectin E 1.42101
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 1.41856
PRKCA protein kinase C, alpha 1.41856
CYCS cytochrome c, somatic 1.41505
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 1.41424
CCNE1 cyclin E1 1.41285
GATA3 GATA binding protein 3 1.41091
TJP1 tight junction protein 1 1.40925
E2F1 E2F transcription factor 1 1.40732
IL4 interleukin 4 1.4065
CTSB cathepsin B 1.40288
KRAS Kirsten rat sarcoma viral oncogene homolog 1.40288
NCF2 neutrophil cytosolic factor 2 1.40036
CCNA2 cyclin A2 1.3998
CTGF connective tissue growth factor 1.39952
PRL prolactin 1.39813
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 1.39394
BCL3 B-cell CLL/lymphoma 3 1.39366
HSPA9 heat shock 70kDa protein 9 (mortalin) 1.39282
H2AFX H2A histone family, member X 1.3903
CALR calreticulin 1.3903
GDF15 growth differentiation factor 15 1.3903
IL5 interleukin 5 1.3903
TOP2A topoisomerase (DNA) II alpha 170kDa 1.3903
DRD2 dopamine receptor D2 1.38863
ACO2 aconitase 2, mitochondrial 1.38696
DDIT4 DNA-damage-inducible transcript 4 1.38527
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 1.38498
RGS2 regulator of G-protein signaling 2 1.38498
RASD1 RAS, dexamethasone-induced 1 1.38498
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 1.38384
CDK2 cyclin-dependent kinase 2 1.38384
CHRNA4 cholinergic receptor, nicotinic, alpha 4 (neuronal) 1.38242
GJA1 gap junction protein, alpha 1, 43kDa 1.38128
PRKCB protein kinase C, beta 1.37987
XDH xanthine dehydrogenase 1.37761
ANXA3 annexin A3 1.37733
SQSTM1 sequestosome 1 1.37676
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 1.37561
HSF1 heat shock transcription factor 1 1.37389
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 1.37246
ACACA acetyl-CoA carboxylase alpha 1.3619
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 1.36133
PTX3 pentraxin 3, long 1.35991
GFAP glial fibrillary acidic protein 1.35991
ATF2 activating transcription factor 2 1.35502
ODC1 ornithine decarboxylase 1 1.35473
ACSL1 acyl-CoA synthetase long-chain family member 1 1.35444
STAR steroidogenic acute regulatory protein 1.35299
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 1.35069
NR1H3 nuclear receptor subfamily 1, group H, member 3 1.34897
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha 1.34782
PRDX6 peroxiredoxin 6 1.34606
UBE2C ubiquitin-conjugating enzyme E2C 1.34606
MT1A metallothionein 1A 1.34576
CHAT choline O-acetyltransferase 1.3443
RAF1 Raf-1 proto-oncogene, serine/threonine kinase 1.34372
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD) 1.34285
MT2A metallothionein 2A 1.34169
ADRB2 adrenoceptor beta 2, surface 1.34169
IGFBP3 insulin-like growth factor binding protein 3 1.34169
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 1.33995
LPL lipoprotein lipase 1.33938
GSTA1 glutathione S-transferase alpha 1 1.33761
PPP1R15A protein phosphatase 1, regulatory subunit 15A 1.33731
COL3A1 collagen, type III, alpha 1 1.33731
GOT1 glutamic-oxaloacetic transaminase 1, soluble 1.33701
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 1.33642
MTOR mechanistic target of rapamycin (serine/threonine kinase) 1.33583
INSIG1 insulin induced gene 1 1.33494
CXCL10 chemokine (C-X-C motif) ligand 10 1.3311
GCH1 GTP cyclohydrolase 1 1.32816
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 1.32786
CHRNB1 cholinergic receptor, nicotinic, beta 1 (muscle) 1.32637
GSTM2 glutathione S-transferase mu 2 (muscle) 1.32577
CRYAB crystallin, alpha B 1.31867
SPHK1 sphingosine kinase 1 1.31776
SOX9 SRY (sex determining region Y)-box 9 1.31776
SOD3 superoxide dismutase 3, extracellular 1.31656
CRP C-reactive protein, pentraxin-related 1.31626
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) 1.31626
TRAF2 TNF receptor-associated factor 2 1.31596
TFF1 trefoil factor 1 1.31178
ATF6 activating transcription factor 6 1.31059
PLAUR plasminogen activator, urokinase receptor 1.30941
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2 1.30819
KLF6 Kruppel-like factor 6 1.30543
HGF hepatocyte growth factor (hepapoietin A; scatter factor) 1.30482
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 1.3036
PDGFA platelet-derived growth factor alpha polypeptide 1.30269
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) 1.30269
ATF4 activating transcription factor 4 1.30056
LDHB lactate dehydrogenase B 1.29996
ACTB actin, beta 1.29812
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein 1.29812
NFIL3 nuclear factor, interleukin 3 regulated 1.29657
C3 complement component 3 1.29379
SCARB1 scavenger receptor class B, member 1 1.29133
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 1.29133
S100B S100 calcium binding protein B 1.2895
CSF1 colony stimulating factor 1 (macrophage) 1.2895
MT3 metallothionein 3 1.2861
PDGFB platelet-derived growth factor beta polypeptide 1.2861
HSPG2 heparan sulfate proteoglycan 2 1.28272
FGF2 fibroblast growth factor 2 (basic) 1.28272
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 1.28088
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 1.28088
CD40 CD40 molecule, TNF receptor superfamily member 5 1.28088
CASP6 caspase 6, apoptosis-related cysteine peptidase 1.27845
PRKCE protein kinase C, epsilon 1.27845
PENK proenkephalin 1.27564
ALDH2 aldehyde dehydrogenase 2 family (mitochondrial) 1.27009
HSPA1L heat shock 70kDa protein 1-like 1.26978
KIF20A kinesin family member 20A 1.26947
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2 1.26947
PTK2 protein tyrosine kinase 2 1.26794
RHOA ras homolog family member A 1.26794
ANXA2 annexin A2 1.26794
CYC1 cytochrome c-1 1.26732
CXCL5 chemokine (C-X-C motif) ligand 5 1.26638
APEX1 APEX nuclease (multifunctional DNA repair enzyme) 1 1.26545
CYBA cytochrome b-245, alpha polypeptide 1.26545
CYBB cytochrome b-245, beta polypeptide 1.26298
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1 1.26298
MMP10 matrix metallopeptidase 10 1.26144
PGR progesterone receptor 1.26021
ENC1 ectodermal-neural cortex 1 (with BTB domain) 1.2599
SCD stearoyl-CoA desaturase (delta-9-desaturase) 1.25807
CKB creatine kinase, brain 1.25369
KEAP1 kelch-like ECH-associated protein 1 1.25307
BECN1 beclin 1, autophagy related 1.25059
LIF leukemia inhibitory factor 1.25059
GSTM1 glutathione S-transferase mu 1 1.25028
PDE5A phosphodiesterase 5A, cGMP-specific 1.24905
CFLAR CASP8 and FADD-like apoptosis regulator 1.24812
SEPP1 selenoprotein P, plasma, 1 1.2475
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 1.24623
TAC1 tachykinin, precursor 1 1.24623
IRS1 insulin receptor substrate 1 1.2456
ANXA1 annexin A1 1.24087
IFRD1 interferon-related developmental regulator 1 1.23837
MSMO1 methylsterol monooxygenase 1 1.23552
AR androgen receptor 1.23488
ETFB electron-transfer-flavoprotein, beta polypeptide 1.23328
FDPS farnesyl diphosphate synthase 1.23233
GPX3 glutathione peroxidase 3 1.23137
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4 1.23137
GSS glutathione synthetase 1.22948
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 1.22948
CALCA calcitonin-related polypeptide alpha 1.2279
UBB ubiquitin B 1.2279
DRD1 dopamine receptor D1 1.22664
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 1.22436
HIF3A hypoxia inducible factor 3, alpha subunit 1.22242
PTPN1 protein tyrosine phosphatase, non-receptor type 1 1.22177
SOCS3 suppressor of cytokine signaling 3 1.22177
PDE4D phosphodiesterase 4D, cAMP-specific 1.21759
RAMP2 receptor (G protein-coupled) activity modifying protein 2 1.21759
NME2 NME/NM23 nucleoside diphosphate kinase 2 1.21759
HMGB1 high mobility group box 1 1.21759
AREG amphiregulin 1.21727
GSTA2 glutathione S-transferase alpha 2 1.21534
SGK1 serum/glucocorticoid regulated kinase 1 1.21501
TK1 thymidine kinase 1, soluble 1.21468
SUV39H2 suppressor of variegation 3-9 homolog 2 (Drosophila) 1.21468
GPAM glycerol-3-phosphate acyltransferase, mitochondrial 1.21402
HSPB8 heat shock 22kDa protein 8 1.21402
MRPS7 mitochondrial ribosomal protein S7 1.21304
MMP13 matrix metallopeptidase 13 1.21271
AQP3 aquaporin 3 (Gill blood group) 1.21206
FOSB FBJ murine osteosarcoma viral oncogene homolog B 1.21206
CXCR4 chemokine (C-X-C motif) receptor 4 1.21043
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 1.21011
CCND2 cyclin D2 1.20816
EGLN1 egl-9 family hypoxia-inducible factor 1 1.20719
SLC19A1 solute carrier family 19 (folate transporter), member 1 1.20654
SMAD7 SMAD family member 7 1.20654
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 1.20654
BMP4 bone morphogenetic protein 4 1.20622
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 1.20526
PECAM1 platelet/endothelial cell adhesion molecule 1 1.20295
CAMK4 calcium/calmodulin-dependent protein kinase IV 1.20229
SLC2A2 solute carrier family 2 (facilitated glucose transporter), member 2 1.20064
IL1R1 interleukin 1 receptor, type I 1.20064
EMC3 ER membrane protein complex subunit 3 1.20064
PON1 paraoxonase 1 1.19966
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta 1.19933
MGMT O-6-methylguanine-DNA methyltransferase 1.199
PRDX2 peroxiredoxin 2 1.1977
DYNLL1 dynein, light chain, LC8-type 1 1.19704
IER5 immediate early response 5 1.19704
LYZ lysozyme 1.19704
S100A9 S100 calcium binding protein A9 1.19246
CLCF1 cardiotrophin-like cytokine factor 1 1.19246
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 1.19246
WISP2 WNT1 inducible signaling pathway protein 2 1.19246
CBS cystathionine-beta-synthase 1.19213
ERBB3 erb-b2 receptor tyrosine kinase 3 1.19213
EP300 E1A binding protein p300 1.18882
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 1.18882
CDC25A cell division cycle 25A 1.18882
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 1.18751
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 1.18751
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 1.18685
HAVCR1 hepatitis A virus cellular receptor 1 1.18521
DLD dihydrolipoamide dehydrogenase 1.18293
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 1.18293
IRS2 insulin receptor substrate 2 1.18193
THBD thrombomodulin 1.18193
HBEGF heparin-binding EGF-like growth factor 1.18159
HRAS Harvey rat sarcoma viral oncogene homolog 1.17993
TIMM17A translocase of inner mitochondrial membrane 17 homolog A (yeast) 1.1786
NDUFS4 NADH dehydrogenase (ubiquinone) Fe-S protein 4, 18kDa (NADH-coenzyme Q reductase) 1.1786
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 1.17827
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit 1.17827
MCL1 myeloid cell leukemia 1 1.17794
IL6ST interleukin 6 signal transducer 1.17497
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble 1.17497
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 1.17497
ARG1 arginase 1 1.17366
MYH10 myosin, heavy chain 10, non-muscle 1.17366
MARCKS myristoylated alanine-rich protein kinase C substrate 1.17168
PMP22 peripheral myelin protein 22 1.17168
COL1A2 collagen, type I, alpha 2 1.17101
AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1 1.17101
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2 1.17101
AKR1C1 aldo-keto reductase family 1, member C1 1.169
MAL mal, T-cell differentiation protein 1.169
GLUL glutamate-ammonia ligase 1.16866
MAP2K6 mitogen-activated protein kinase kinase 6 1.16833
MYD88 myeloid differentiation primary response 88 1.16833
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit 1.16833
B4GALT2 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 2 1.16666
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 1.166
PKM pyruvate kinase, muscle 1.166
S100A8 S100 calcium binding protein A8 1.166
CA2 carbonic anhydrase II 1.166
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 1.16467
CD86 CD86 molecule 1.16302
GSTP1 glutathione S-transferase pi 1 1.16203
SMAD3 SMAD family member 3 1.16104
HTR2A 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled 1.16104
GEM GTP binding protein overexpressed in skeletal muscle 1.16001
CKS1B CDC28 protein kinase regulatory subunit 1B 1.16001
GRIN2C glutamate receptor, ionotropic, N-methyl D-aspartate 2C 1.16001
ADAM17 ADAM metallopeptidase domain 17 1.16001
PNPLA8 patatin-like phospholipase domain containing 8 1.15865
BBC3 BCL2 binding component 3 1.15831
ARNT aryl hydrocarbon receptor nuclear translocator 1.15593
SCD5 stearoyl-CoA desaturase 5 1.1556
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 1.1556
RAC1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) 1.15324
GABARAPL1 GABA(A) receptor-associated protein like 1 1.15256
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip) 1.15256
CDK4 cyclin-dependent kinase 4 1.15223
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 1.15189
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 1.15122
TACC3 transforming, acidic coiled-coil containing protein 3 1.15122
LIPE lipase, hormone-sensitive 1.15122
APOB apolipoprotein B 1.1485
ACTC1 actin, alpha, cardiac muscle 1 1.14713
MXD1 MAX dimerization protein 1 1.14713
AP1S3 adaptor-related protein complex 1, sigma 3 subunit 1.14644
MRPL33 mitochondrial ribosomal protein L33 1.1461
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide 1.14575
FABP1 fatty acid binding protein 1, liver 1.14575
GADD45B growth arrest and DNA-damage-inducible, beta 1.14575
DIABLO diablo, IAP-binding mitochondrial protein 1.14234
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 1.14098
S100A6 S100 calcium binding protein A6 1.13929
S100A4 S100 calcium binding protein A4 1.13929
IER3 immediate early response 3 1.13862
KDR kinase insert domain receptor 1.13862
HK1 hexokinase 1 1.13862
KAZALD1 Kazal-type serine peptidase inhibitor domain 1 1.13655
SLC6A4 solute carrier family 6 (neurotransmitter transporter), member 4 1.13621
HNF4A hepatocyte nuclear factor 4, alpha 1.13621
PGAM1 phosphoglycerate mutase 1 (brain) 1.13449
ENO3 enolase 3 (beta, muscle) 1.13449
CDH3 cadherin 3, type 1, P-cadherin (placental) 1.13415
KDM3A lysine (K)-specific demethylase 3A 1.13415
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 1.13041
AGTR2 angiotensin II receptor, type 2 1.13041
ERCC1 excision repair cross-complementation group 1 1.13007
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1 1.12838
WNT1 wingless-type MMTV integration site family, member 1 1.12737
UPP1 uridine phosphorylase 1 1.12634
EGF epidermal growth factor 1.12461
AHR aryl hydrocarbon receptor 1.12426
OCLN occludin 1.12426
FXYD5 FXYD domain containing ion transport regulator 5 1.12254
NFE2L1 nuclear factor, erythroid 2-like 1 1.12254
ITGAV integrin, alpha V 1.12219
IL1RN interleukin 1 receptor antagonist 1.12185
GSTT1 glutathione S-transferase theta 1 1.12151
PTGR1 prostaglandin reductase 1 1.12117
ARG2 arginase 2 1.12117
HSPA1B heat shock 70kDa protein 1B 1.1198
AQP4 aquaporin 4 1.11843
MUC5AC mucin 5AC, oligomeric mucus/gel-forming 1.11843
ATP5O ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit 1.11707
FSHB follicle stimulating hormone, beta polypeptide 1.11571
RGS16 regulator of G-protein signaling 16 1.11466
SYP synaptophysin 1.11466
ALPL alkaline phosphatase, liver/bone/kidney 1.1129
DIO2 deiodinase, iodothyronine, type II 1.11255
AK3 adenylate kinase 3 1.11116
NES nestin 1.11046
ACTA1 actin, alpha 1, skeletal muscle 1.11046
PLA2G7 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) 1.11046
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 1.11046
MAP1LC3B microtubule-associated protein 1 light chain 3 beta 1.10942
MCCC1 methylcrotonoyl-CoA carboxylase 1 (alpha) 1.10942
HSPA8 heat shock 70kDa protein 8 1.10838
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2) 1.10665
NRF1 nuclear respiratory factor 1 1.10665
INSR insulin receptor 1.10665
GPRC5A G protein-coupled receptor, class C, group 5, member A 1.10596
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme 1.10596
MBP myelin basic protein 1.10388
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 1.10388
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B 1.10388
IDI1 isopentenyl-diphosphate delta isomerase 1 1.10388
AGER advanced glycosylation end product-specific receptor 1.10317
DHRS3 dehydrogenase/reductase (SDR family) member 3 1.10282
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 1.10104
S100A14 S100 calcium binding protein A14 1.10104
ERBB4 erb-b2 receptor tyrosine kinase 4 1.10069
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 1.10033
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 1.09963
FKBP4 FK506 binding protein 4, 59kDa 1.09927
EIF5 eukaryotic translation initiation factor 5 1.09927
IL12A interleukin 12A 1.09716
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 1.09506
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 1.09366
CTSS cathepsin S 1.0919
LITAF lipopolysaccharide-induced TNF factor 1.0919
GSTM3 glutathione S-transferase mu 3 (brain) 1.09047
ALAD aminolevulinate dehydratase 1.08975
BCL10 B-cell CLL/lymphoma 10 1.08975
GPC1 glypican 1 1.08975
TNK2 tyrosine kinase, non-receptor, 2 1.08478
MRE11A MRE11 meiotic recombination 11 homolog A (S. cerevisiae) 1.08478
DES desmin 1.08442
SQLE squalene epoxidase 1.08442
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 1.08442
STIP1 stress-induced phosphoprotein 1 1.08442
GRIA1 glutamate receptor, ionotropic, AMPA 1 1.08091
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 1.07983
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 1.07983
GADD45G growth arrest and DNA-damage-inducible, gamma 1.07875
IGFBP5 insulin-like growth factor binding protein 5 1.07875
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 1.07732
EMP1 epithelial membrane protein 1 1.07732
UHRF1 ubiquitin-like with PHD and ring finger domains 1 1.07732
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1 1.07696
G6PC glucose-6-phosphatase, catalytic subunit 1.07625
CNN3 calponin 3, acidic 1.07482
SREBF1 sterol regulatory element binding transcription factor 1 1.07447
KLF5 Kruppel-like factor 5 (intestinal) 1.07376
BDKRB2 bradykinin receptor B2 1.07376
TOP1 topoisomerase (DNA) I 1.07376
UCP2 uncoupling protein 2 (mitochondrial, proton carrier) 1.0734
PPARD peroxisome proliferator-activated receptor delta 1.07093
CD9 CD9 molecule 1.07022
MME membrane metallo-endopeptidase 1.07022
EPOR erythropoietin receptor 1.06987
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5 1.06987
CRYZ crystallin, zeta (quinone reductase) 1.06987
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme 1.06952
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 1.06952
RPS6 ribosomal protein S6 1.06844
POMC proopiomelanocortin 1.06844
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 1.06698
ALDOC aldolase C, fructose-bisphosphate 1.06698
RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 1.06698
BCAR1 breast cancer anti-estrogen resistance 1 1.06515
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 1.06479
LAMA5 laminin, alpha 5 1.06479
TPD52L1 tumor protein D52-like 1 1.06479
IVNS1ABP influenza virus NS1A binding protein 1.06479
IL11 interleukin 11 1.06333
DUSP5 dual specificity phosphatase 5 1.06333
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1 1.06333
CYP7A1 cytochrome P450, family 7, subfamily A, polypeptide 1 1.06297
AKR1A1 aldo-keto reductase family 1, member A1 (aldehyde reductase) 1.06008
PPIF peptidylprolyl isomerase F 1.06008
BCL2A1 BCL2-related protein A1 1.06008
ATP2A2 ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 1.05793
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 1.05535
PTGIS prostaglandin I2 (prostacyclin) synthase 1.05535
AK2 adenylate kinase 2 1.05535
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila) 1.05461
GABPA GA binding protein transcription factor, alpha subunit 60kDa 1.05461
RFXAP regulatory factor X-associated protein 1.05163
IPO9 importin 9 1.05126
GRB10 growth factor receptor-bound protein 10 1.05052
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 1.05052
TIMP3 TIMP metallopeptidase inhibitor 3 1.05015
RAD51 RAD51 recombinase 1.05015
PER2 period circadian clock 2 1.04978
PHGDH phosphoglycerate dehydrogenase 1.04978
SP7 Sp7 transcription factor 1.04794
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b 1.04757
BNIP2 BCL2/adenovirus E1B 19kDa interacting protein 2 1.04721
BUB1 BUB1 mitotic checkpoint serine/threonine kinase 1.04647
GNRH1 gonadotropin-releasing hormone 1 (luteinizing-releasing hormone) 1.04647
GPX2 glutathione peroxidase 2 1.04501
COX1 1.04314
LTF lactotransferrin 1.04314
CX3CL1 chemokine (C-X3-C motif) ligand 1 1.04314
DCLK1 doublecortin-like kinase 1 1.04126
UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 1.04051
PIM3 Pim-3 proto-oncogene, serine/threonine kinase 1.04014
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein 1.04014
ADRB1 adrenoceptor beta 1 1.04014
ESPN espin 1.04014
JAK1 Janus kinase 1 1.03976
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4 1.03976
SLC7A4 solute carrier family 7, member 4 1.03939
SLC37A2 solute carrier family 37 (glucose-6-phosphate transporter), member 2 1.03901
KNG1 kininogen 1 1.03752
MT1E metallothionein 1E 1.03678
CLIC4 chloride intracellular channel 4 1.03678
NUF2 NUF2, NDC80 kinetochore complex component 1.03678
PAWR PRKC, apoptosis, WT1, regulator 1.03678
PARK2 parkin RBR E3 ubiquitin protein ligase 1.03678
PGF placental growth factor 1.03678
SNAI2 snail family zinc finger 2 1.03678
PTGES prostaglandin E synthase 1.03641
KLHL21 kelch-like family member 21 1.03345
BUB1B BUB1 mitotic checkpoint serine/threonine kinase B 1.03345
RAP1GAP RAP1 GTPase activating protein 1.03345
FNTB farnesyltransferase, CAAX box, beta 1.03345
MYH7 myosin, heavy chain 7, cardiac muscle, beta 1.03345
TOMM40 translocase of outer mitochondrial membrane 40 homolog (yeast) 1.03345
FOXA2 forkhead box A2 1.03235
PC pyruvate carboxylase 1.03235
NPPB natriuretic peptide B 1.03009
FTH1 ferritin, heavy polypeptide 1 1.03009
TLR2 toll-like receptor 2 1.03009
PRDX1 peroxiredoxin 1 1.02783
CPE carboxypeptidase E 1.02783
PHB prohibitin 1.02708
FAM64A family with sequence similarity 64, member A 1.02671
SLC9A3 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 1.02671
ABCF2 ATP-binding cassette, sub-family F (GCN20), member 2 1.02671
ASNS asparagine synthetase (glutamine-hydrolyzing) 1.02522
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 1.02373
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 1.02373
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) 1.02373
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 1.02299
GHR growth hormone receptor 1.02077
ACLY ATP citrate lyase 1.02077
WISP1 WNT1 inducible signaling pathway protein 1 1.0204
DNMT1 DNA (cytosine-5-)-methyltransferase 1 1.0204
AMD1 adenosylmethionine decarboxylase 1 1.0204
HIST1H2BD histone cluster 1, H2bd 1.0204
SPAG9 sperm associated antigen 9 1.0204
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 1.01928
TFPI2 tissue factor pathway inhibitor 2 1.01928
CCNB2 cyclin B2 1.01587
CD47 CD47 molecule 1.01512
GSTA5 glutathione S-transferase alpha 5 1.01474
EPAS1 endothelial PAS domain protein 1 1.01474
MRPL12 mitochondrial ribosomal protein L12 1.01361
MGST1 microsomal glutathione S-transferase 1 1.01324
GSTA3 glutathione S-transferase alpha 3 1.01324
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 1.01174
HDAC1 histone deacetylase 1 1.01137