Alzheimer's disease Gene Set

Dataset GWAS Catalog SNP-Phenotype Associations
Category disease or phenotype associations
Type phenotype
Description A tauopathy that results in progressive memory loss, impaired thinking, disorientation, and changes in personality and mood starting and leads in advanced cases to a profound decline in cognitive and physical functioning and is marked histologically by the degeneration of brain neurons especially in the cerebral cortex and by the presence of neurofibrillary tangles and plaques containing beta-amyloid. It is characterized by memory lapses, confusion, emotional instability and progressive loss of mental ability. (Human Disease Ontology, DOID_10652)
External Link https://www.ebi.ac.uk/gwas/search?query=Alzheimer's disease
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Genes

33 genes associated with the Alzheimer's disease phenotype in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations dataset.

Symbol Name Standardized Value
TOMM40 translocase of outer mitochondrial membrane 40 homolog (yeast) 2.75549
APOC1 apolipoprotein C-I 2.12754
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7 0.923741
MS4A6A membrane-spanning 4-domains, subfamily A, member 6A 0.802698
CR1 complement component (3b/4b) receptor 1 (Knops blood group) 0.786836
PVRL2 poliovirus receptor-related 2 (herpesvirus entry mediator B) 0.77738
TREM2 triggering receptor expressed on myeloid cells 2 0.696558
CLU clusterin 0.526478
PICALM phosphatidylinositol binding clathrin assembly protein 0.405958
BMPER BMP binding endothelial regulator 0.342586
PCDH11X protocadherin 11 X-linked 0.314454
PPP1R3B protein phosphatase 1, regulatory subunit 3B 0.295129
VSNL1 visinin-like 1 0.255654
SLC8A1-AS1 SLC8A1 antisense RNA 1 0.246511
MMP12 matrix metallopeptidase 12 0.220915
BIN1 bridging integrator 1 0.220915
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific) 0.220915
LOC101927587 uncharacterized LOC101927587 0.220915
RELN reelin 0.165905
SLC4A1AP solute carrier family 4 (anion exchanger), member 1, adaptor protein 0.165905
LRAT lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase) 0.129504
STK24 serine/threonine kinase 24 0.104568
ZNF320 zinc finger protein 320 0.085234
C5ORF64 chromosome 5 open reading frame 64 0.085234
RNF6 ring finger protein (C3H2C3 type) 6 0.085234
CD33 CD33 molecule 0.070053
POLN polymerase (DNA directed) nu 0.070053
LOC102724399 0.048624
PROX1-AS1 PROX1 antisense RNA 1 0.048624
STK11 serine/threonine kinase 11 0.048624
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.048624
MPP7 membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7) 0.042592
CNTNAP2 contactin associated protein-like 2 0.042592