Acidosis, Lactic Gene Set

Dataset CTD Gene-Disease Associations
Category disease or phenotype associations
Type disease
External Link http://ctdbase.org/detail.go?type=disease&acc=MESH:D000140
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Genes

231 genes/proteins associated with the disease Acidosis, Lactic from the curated CTD Gene-Disease Associations dataset.

Symbol Name Standardized Value
MT-TL1 tRNA 2.88009
DNM1L dynamin 1-like 2.88009
PDHA1 pyruvate dehydrogenase (lipoamide) alpha 1 2.88009
PLAT plasminogen activator, tissue 2.88009
IFNG interferon, gamma 1.90656
TNF tumor necrosis factor 1.82376
EDN1 endothelin 1 1.79827
ADIPOQ adiponectin, C1Q and collagen domain containing 1.77472
LPL lipoprotein lipase 1.76366
LEP leptin 1.69638
ALB albumin 1.68062
FASN fatty acid synthase 1.669
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.66038
IL6 interleukin 6 1.64101
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha 1.63294
SOD2 superoxide dismutase 2, mitochondrial 1.62669
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1) 1.58279
PPARG peroxisome proliferator-activated receptor gamma 1.58255
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic 1.57782
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 1.55871
SHH sonic hedgehog 1.54693
JUN jun proto-oncogene 1.54596
BCL2 B-cell CLL/lymphoma 2 1.53357
HMOX1 heme oxygenase 1 1.5108
CAT catalase 1.50675
NOS2 nitric oxide synthase 2, inducible 1.49711
NOS3 nitric oxide synthase 3 (endothelial cell) 1.4933
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 1.48608
PRKCZ protein kinase C, zeta 1.47787
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 1.4567
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 1.45643
CCND2 cyclin D2 1.44544
CPT1A carnitine palmitoyltransferase 1A (liver) 1.43428
FAS Fas cell surface death receptor 1.42777
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 1.42401
MAPK1 mitogen-activated protein kinase 1 1.39198
IKZF4 IKAROS family zinc finger 4 (Eos) 1.39114
FOS FBJ murine osteosarcoma viral oncogene homolog 1.38946
MMP2 matrix metallopeptidase 2 1.38584
CCL2 chemokine (C-C motif) ligand 2 1.38213
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 1.38213
LAMC2 laminin, gamma 2 1.36677
POU5F1 POU class 5 homeobox 1 1.36104
SREBF1 sterol regulatory element binding transcription factor 1 1.35098
VEGFA vascular endothelial growth factor A 1.35098
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 1.34489
SLC2A4 solute carrier family 2 (facilitated glucose transporter), member 4 1.33199
UCP1 uncoupling protein 1 (mitochondrial, proton carrier) 1.33081
IL10 interleukin 10 1.33022
TP53 tumor protein p53 1.32399
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) 1.31867
SEPHS2 selenophosphate synthetase 2 1.31776
BAX BCL2-associated X protein 1.30881
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 1.2975
UCP2 uncoupling protein 2 (mitochondrial, proton carrier) 1.29688
MMP9 matrix metallopeptidase 9 1.29317
DDIT3 DNA-damage-inducible transcript 3 1.28889
BDNF brain-derived neurotrophic factor 1.2861
IL2RA interleukin 2 receptor, alpha 1.27997
CXCL8 chemokine (C-X-C motif) ligand 8 1.27533
TGFB1 transforming growth factor, beta 1 1.27471
CCRN4L CCR4 carbon catabolite repression 4-like (S. cerevisiae) 1.27316
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 1.25899
SPP1 secreted phosphoprotein 1 1.25651
GUCY1B3 guanylate cyclase 1, soluble, beta 3 1.25214
SPINK5 serine peptidase inhibitor, Kazal type 5 1.25028
CASP7 caspase 7, apoptosis-related cysteine peptidase 1.24997
NAP1L5 nucleosome assembly protein 1-like 5 1.24997
NGF nerve growth factor (beta polypeptide) 1.24935
FOXA2 forkhead box A2 1.24528
PDK4 pyruvate dehydrogenase kinase, isozyme 4 1.24496
G6PC glucose-6-phosphatase, catalytic subunit 1.24118
CD36 CD36 molecule (thrombospondin receptor) 1.24024
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) 1.23899
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 1.2352
PARP1 poly (ADP-ribose) polymerase 1 1.22948
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 1.22916
NPPA natriuretic peptide A 1.22884
RBL1 retinoblastoma-like 1 1.22306
PRKCB protein kinase C, beta 1.22242
STAR steroidogenic acute regulatory protein 1.21206
MAPK3 mitogen-activated protein kinase 3 1.21173
CCNG1 cyclin G1 1.20816
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5 1.20816
MAP2K2 mitogen-activated protein kinase kinase 2 1.20622
PCNA proliferating cell nuclear antigen 1.20493
TH tyrosine hydroxylase 1.20394
HSPB1 heat shock 27kDa protein 1 1.20163
IRS1 insulin receptor substrate 1 1.2013
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 1.19999
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.19933
EGR1 early growth response 1 1.19672
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 1.19574
UQCRB ubiquinol-cytochrome c reductase binding protein 1.19542
COL3A1 collagen, type III, alpha 1 1.19279
EIF2A eukaryotic translation initiation factor 2A, 65kDa 1.18587
OPA1 optic atrophy 1 (autosomal dominant) 1.18521
OAZ3 ornithine decarboxylase antizyme 3 1.18326
ASS1 argininosuccinate synthase 1 1.18059
SFXN2 sideroflexin 2 1.18026
NUPR1 nuclear protein, transcriptional regulator, 1 1.17959
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 1.17794
IGF1 insulin-like growth factor 1 (somatomedin C) 1.17596
PPP1R2 protein phosphatase 1, regulatory (inhibitor) subunit 2 1.17497
CAPN2 calpain 2, (m/II) large subunit 1.173
TRIB3 tribbles pseudokinase 3 1.17202
PRDM1 PR domain containing 1, with ZNF domain 1.17067
PLCG1 phospholipase C, gamma 1 1.17034
IL12B interleukin 12B 1.16967
BTG2 BTG family, member 2 1.169
CDC25A cell division cycle 25A 1.16766
FOSL2 FOS-like antigen 2 1.16766
CD44 CD44 molecule (Indian blood group) 1.16001
HADH hydroxyacyl-CoA dehydrogenase 1.15831
MARCKS myristoylated alanine-rich protein kinase C substrate 1.1556
SLC22A3 solute carrier family 22 (organic cation transporter), member 3 1.15357
MYD88 myeloid differentiation primary response 88 1.15324
CREB1 cAMP responsive element binding protein 1 1.15256
SLC7A8 solute carrier family 7 (amino acid transporter light chain, L system), member 8 1.15156
GPX1 glutathione peroxidase 1 1.15055
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 1.15055
ELOVL3 ELOVL fatty acid elongase 3 1.14781
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 1.14473
GFAP glial fibrillary acidic protein 1.14098
VAT1 vesicle amine transport 1 1.13895
ATP5H ATP synthase, H+ transporting, mitochondrial Fo complex, subunit d 1.13895
REN renin 1.13552
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 1.13381
IL1B interleukin 1, beta 1.13347
S100A4 S100 calcium binding protein A4 1.13279
HNF4A hepatocyte nuclear factor 4, alpha 1.13041
CCND1 cyclin D1 1.12668
SEPP1 selenoprotein P, plasma, 1 1.12634
G0S2 G0/G1 switch 2 1.12634
CCNL1 cyclin L1 1.11501
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 1.11396
TMEM64 transmembrane protein 64 1.11011
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2) 1.10977
CTGF connective tissue growth factor 1.10527
PRKACB protein kinase, cAMP-dependent, catalytic, beta 1.10388
CCNE2 cyclin E2 1.10388
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 1.10033
EPOR erythropoietin receptor 1.10033
GAPDH glyceraldehyde-3-phosphate dehydrogenase 1.09998
APOA1 apolipoprotein A-I 1.09892
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 1.09366
IFITM1 interferon induced transmembrane protein 1 1.09332
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 1.09332
MAD2L2 MAD2 mitotic arrest deficient-like 2 (yeast) 1.09297
RB1 retinoblastoma 1 1.09083
KLF6 Kruppel-like factor 6 1.09011
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 1.09011
PLSCR1 phospholipid scramblase 1 1.08975
ICAM1 intercellular adhesion molecule 1 1.0894
LAMB3 laminin, beta 3 1.08655
SLC16A6 solute carrier family 16, member 6 1.08301
CEBPB CCAAT/enhancer binding protein (C/EBP), beta 1.08301
PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit 1.08019
KLHL28 kelch-like family member 28 1.07875
RPAIN RPA interacting protein 1.07875
KIFC2 kinesin family member C2 1.0784
NFE2L2 nuclear factor, erythroid 2-like 2 1.07696
KYNU kynureninase 1.0766
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 1.07589
GLUL glutamate-ammonia ligase 1.07163
GNAI2 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 2 1.07022
S100A8 S100 calcium binding protein A8 1.07022
PKM pyruvate kinase, muscle 1.07022
CA2 carbonic anhydrase II 1.07022
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 1.06917
INSIG2 insulin induced gene 2 1.06734
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 1.06479
GAMT guanidinoacetate N-methyltransferase 1.06442
SLC39A14 solute carrier family 39 (zinc transporter), member 14 1.0637
KRT18 keratin 18, type I 1.06297
CYBA cytochrome b-245, alpha polypeptide 1.06297
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4 1.06152
HIST1H4I histone cluster 1, H4i 1.05864
ACACA acetyl-CoA carboxylase alpha 1.05793
NCL nucleolin 1.05793
TXN thioredoxin 1.05274
ASNS asparagine synthetase (glutamine-hydrolyzing) 1.05274
LIFR leukemia inhibitory factor receptor alpha 1.052
ECHS1 enoyl CoA hydratase, short chain, 1, mitochondrial 1.052
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 1.05163
PHF6 PHD finger protein 6 1.05126
SLC25A12 solute carrier family 25 (aspartate/glutamate carrier), member 12 1.05052
MPO myeloperoxidase 1.05052
KDM5A lysine (K)-specific demethylase 5A 1.04978
MAPK9 mitogen-activated protein kinase 9 1.04904
CCNA2 cyclin A2 1.04611
ANXA1 annexin A1 1.04611
SLC2A8 solute carrier family 2 (facilitated glucose transporter), member 8 1.04352
LPIN1 lipin 1 1.04014
C3AR1 complement component 3a receptor 1 1.03939
INSIG1 insulin induced gene 1 1.03939
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8) 1.03901
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 1.03493
SYP synaptophysin 1.03456
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 1.03159
FN1 fibronectin 1 1.03122
NRF1 nuclear respiratory factor 1 1.03009
RBL2 retinoblastoma-like 2 1.02971
ALOX5AP arachidonate 5-lipoxygenase-activating protein 1.02971
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1 1.02933
FOLR1 folate receptor 1 (adult) 1.02896
SLC25A19 solute carrier family 25 (mitochondrial thiamine pyrophosphate carrier), member 19 1.02821
IL4 interleukin 4 1.02634
DDHD1 DDHD domain containing 1 1.02634
ISG15 ISG15 ubiquitin-like modifier 1.02634
F3 coagulation factor III (thromboplastin, tissue factor) 1.02522
CFD complement factor D (adipsin) 1.0241
SLC38A2 solute carrier family 38, member 2 1.02373
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase) 1.02373
SST somatostatin 1.02114
TK2 thymidine kinase 2, mitochondrial 1.0204
HGF hepatocyte growth factor (hepapoietin A; scatter factor) 1.01928
IGFBP1 insulin-like growth factor binding protein 1 1.01928
AQP9 aquaporin 9 1.0189
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 1.01852
LITAF lipopolysaccharide-induced TNF factor 1.01852
LEPR leptin receptor 1.01776
PTGDS prostaglandin D2 synthase 21kDa (brain) 1.01625
ACTB actin, beta 1.01437
PPP2R5C protein phosphatase 2, regulatory subunit B', gamma 1.01437
INADL InaD-like (Drosophila) 1.01399
GSR glutathione reductase 1.01361
CAV1 caveolin 1, caveolae protein, 22kDa 1.01174
NTS neurotensin 1.01062
ETV6 ets variant 6 1.01025
POMC proopiomelanocortin 1.01025