2min_cross-link_ZAP-70_null vs reconstituted_Jurkat (Human) [19605366] Gene Set

Dataset SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Gene Perturbations
Category proteomics
Type gene perturbation
Description gene perturbation identified as [gene perturbation]_[cell line] ([organism]) [[publication PMID]] (SILAC Phosphoproteomics)
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Genes

103 proteins differentially phosphorylated following the 2min_cross-link_ZAP-70_null vs reconstituted_Jurkat (Human) [19605366] gene perturbation from the SILAC Phosphoproteomics Signatures of Differentially Phosphorylated Proteins for Gene Perturbations dataset.

increased phosphorylation

Symbol Name
ACP1 acid phosphatase 1, soluble
ACTA1 actin, alpha 1, skeletal muscle
ACTR10 actin-related protein 10 homolog (S. cerevisiae)
ADA adenosine deaminase
ADAM9 ADAM metallopeptidase domain 9
AHCY adenosylhomocysteinase
ANXA11 annexin A11
ANXA2 annexin A2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CASKIN2 CASK interacting protein 2
CCT8 chaperonin containing TCP1, subunit 8 (theta)
CD247 CD247 molecule
CD3E CD3e molecule, epsilon (CD3-TCR complex)
CD3G CD3g molecule, gamma (CD3-TCR complex)
CD82 CD82 molecule
CD84 CD84 molecule
CGN cingulin
CLTC clathrin, heavy chain (Hc)
CRKL v-crk avian sarcoma virus CT10 oncogene homolog-like
CYFIP1 cytoplasmic FMR1 interacting protein 1
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DOK1 docking protein 1, 62kDa (downstream of tyrosine kinase 1)
DOK2 docking protein 2, 56kDa
DPYSL2 dihydropyrimidinase-like 2
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
DYRK1B dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B
EEF1A1 eukaryotic translation elongation factor 1 alpha 1
EIF3M eukaryotic translation initiation factor 3, subunit M
ELP3 elongator acetyltransferase complex subunit 3
ENO2 enolase 2 (gamma, neuronal)
EPHA3 EPH receptor A3
ERBB2IP erbb2 interacting protein
FER fer (fps/fes related) tyrosine kinase
FLNB filamin B, beta
FYB FYN binding protein
FYN FYN proto-oncogene, Src family tyrosine kinase
G6PD glucose-6-phosphate dehydrogenase
GAB2 GRB2-associated binding protein 2
GOLGA5 golgin A5
HGS hepatocyte growth factor-regulated tyrosine kinase substrate
HIST2H2BE histone cluster 2, H2be
HIST4H4 histone cluster 4, H4
HNRNPH3 heterogeneous nuclear ribonucleoprotein H3 (2H9)
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A)
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA14 heat shock 70kDa protein 14
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)
ITSN2 intersectin 2
LAX1 lymphocyte transmembrane adaptor 1
LCK LCK proto-oncogene, Src family tyrosine kinase
LDHA lactate dehydrogenase A
LDHB lactate dehydrogenase B
LY9 lymphocyte antigen 9
PAG1 phosphoprotein membrane anchor with glycosphingolipid microdomains 1
PECAM1 platelet/endothelial cell adhesion molecule 1
PGAM1 phosphoglycerate mutase 1 (brain)
PGM1 phosphoglucomutase 1
PHLDB3 pleckstrin homology-like domain, family B, member 3
PI4KA phosphatidylinositol 4-kinase, catalytic, alpha
PIK3AP1 phosphoinositide-3-kinase adaptor protein 1
PKM pyruvate kinase, muscle
PKP4 plakophilin 4
PTPN11 protein tyrosine phosphatase, non-receptor type 11
PTPRA protein tyrosine phosphatase, receptor type, A
R3HCC1L R3H domain and coiled-coil containing 1-like
RAN RAN, member RAS oncogene family
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RPL4 ribosomal protein L4
SDCBP syndecan binding protein (syntenin)
SIT1 signaling threshold regulating transmembrane adaptor 1
SKAP1 src kinase associated phosphoprotein 1
SLAMF6 SLAM family member 6
STAM2 signal transducing adaptor molecule (SH3 domain and ITAM motif) 2
TEC tec protein tyrosine kinase
TFRC transferrin receptor
TMIGD2 transmembrane and immunoglobulin domain containing 2
TRIM25 tripartite motif containing 25
TUBA4A tubulin, alpha 4a
TUBB tubulin, beta class I
TXNRD1 thioredoxin reductase 1
UBASH3B ubiquitin associated and SH3 domain containing B
WDR1 WD repeat domain 1
ZDHHC17 zinc finger, DHHC-type containing 17
ZNF404 zinc finger protein 404

decreased phosphorylation

Symbol Name
ACBD6 acyl-CoA binding domain containing 6
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide
BDH1 3-hydroxybutyrate dehydrogenase, type 1
CD3D CD3d molecule, delta (CD3-TCR complex)
CD5 CD5 molecule
CD7 CD7 molecule
ITK IL2-inducible T-cell kinase
LAT linker for activation of T cells
MPZL1 myelin protein zero-like 1
MSL2 male-specific lethal 2 homolog (Drosophila)
OGN osteoglycin
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
TSG101 tumor susceptibility 101
WAS Wiskott-Aldrich syndrome
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa