15-delta prostaglandin J2-5591 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

200 genes differentially expressed following the 15-delta prostaglandin J2-5591 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABHD4 abhydrolase domain containing 4
ACSL5 acyl-CoA synthetase long-chain family member 5
ADAM17 ADAM metallopeptidase domain 17
ADM adrenomedullin
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
ALOX5 arachidonate 5-lipoxygenase
APOBEC3A apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A
ASIC4 acid sensing (proton gated) ion channel family member 4
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATP6AP2 ATPase, H+ transporting, lysosomal accessory protein 2
ATXN7L1 ataxin 7-like 1
BIN1 bridging integrator 1
CBR3 carbonyl reductase 3
CFAP70 cilia and flagella associated protein 70
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLCN4 chloride channel, voltage-sensitive 4
CLEC4E C-type lectin domain family 4, member E
CPEB1 cytoplasmic polyadenylation element binding protein 1
CSF1R colony stimulating factor 1 receptor
CTSZ cathepsin Z
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
CYP2D6 cytochrome P450, family 2, subfamily D, polypeptide 6
CYP4F11 cytochrome P450, family 4, subfamily F, polypeptide 11
DKK3 dickkopf WNT signaling pathway inhibitor 3
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DOK2 docking protein 2, 56kDa
DUSP1 dual specificity phosphatase 1
FAM171A1 family with sequence similarity 171, member A1
FOSL1 FOS-like antigen 1
GABARAPL1 GABA(A) receptor-associated protein like 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GCLM glutamate-cysteine ligase, modifier subunit
GJA4 gap junction protein, alpha 4, 37kDa
GNAS GNAS complex locus
GPLD1 glycosylphosphatidylinositol specific phospholipase D1
GPX2 glutathione peroxidase 2
HCK HCK proto-oncogene, Src family tyrosine kinase
HIPK2 homeodomain interacting protein kinase 2
HMOX1 heme oxygenase 1
HOXA2 homeobox A2
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IL6R interleukin 6 receptor
INHBE inhibin, beta E
IRF4 interferon regulatory factor 4
KCNH6 potassium channel, voltage gated eag related subfamily H, member 6
KIF21B kinesin family member 21B
KRT16 keratin 16, type I
KRT83 keratin 83, type II
LAIR1 leukocyte-associated immunoglobulin-like receptor 1
LAMB4 laminin, beta 4
LINC00472 long intergenic non-protein coding RNA 472
LRP12 low density lipoprotein receptor-related protein 12
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAFG v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
MAP1B microtubule-associated protein 1B
MEGF6 multiple EGF-like-domains 6
MEP1B meprin A, beta
MOB3B MOB kinase activator 3B
MYL4 myosin, light chain 4, alkali; atrial, embryonic
NDRG1 N-myc downstream regulated 1
NOVA2 neuro-oncological ventral antigen 2
OMD osteomodulin
OSGIN1 oxidative stress induced growth inhibitor 1
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POPDC3 popeye domain containing 3
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PPP2CB protein phosphatase 2, catalytic subunit, beta isozyme
PPP4R4 protein phosphatase 4, regulatory subunit 4
PTCRA pre T-cell antigen receptor alpha
RAI2 retinoic acid induced 2
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RGCC regulator of cell cycle
RNF24 ring finger protein 24
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
SCN10A sodium channel, voltage gated, type X alpha subunit
SEMA4G sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4G
SERPINA7 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SEZ6L seizure related 6 homolog (mouse)-like
SH2B3 SH2B adaptor protein 3
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLCO1A2 solute carrier organic anion transporter family, member 1A2
SQSTM1 sequestosome 1
STYK1 serine/threonine/tyrosine kinase 1
TBX3 T-box 3
TES testin LIM domain protein
TIMP3 TIMP metallopeptidase inhibitor 3
TNFRSF10C tumor necrosis factor receptor superfamily, member 10c, decoy without an intracellular domain
TPMT thiopurine S-methyltransferase
TXNRD1 thioredoxin reductase 1
YY2 YY2 transcription factor
ZNF235 zinc finger protein 235

decreased expression

Symbol Name
ACBD4 acyl-CoA binding domain containing 4
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANXA2P3 annexin A2 pseudogene 3
ATP13A2 ATPase type 13A2
B3GNT1
BAG4 BCL2-associated athanogene 4
BAHCC1 BAH domain and coiled-coil containing 1
C2ORF54 chromosome 2 open reading frame 54
C5AR2 complement component 5a receptor 2
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CBFA2T3 core-binding factor, runt domain, alpha subunit 2; translocated to, 3
CBX4 chromobox homolog 4
CBX7 chromobox homolog 7
CCDC68 coiled-coil domain containing 68
CCP110 centriolar coiled coil protein 110kDa
CDK3 cyclin-dependent kinase 3
CINP cyclin-dependent kinase 2 interacting protein
CLSPN claspin
CLSTN2 calsyntenin 2
CNGB3 cyclic nucleotide gated channel beta 3
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase
CTDSP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1
CUZD1 CUB and zona pellucida-like domains 1
CYP26A1 cytochrome P450, family 26, subfamily A, polypeptide 1
DNA2 DNA replication helicase/nuclease 2
ELMO3 engulfment and cell motility 3
ESRP2 epithelial splicing regulatory protein 2
FAM155B family with sequence similarity 155, member B
FBXO31 F-box protein 31
FLJ11710 uncharacterized protein FLJ11710
GATA4 GATA binding protein 4
GFOD1 glucose-fructose oxidoreductase domain containing 1
GHR growth hormone receptor
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GJA1 gap junction protein, alpha 1, 43kDa
HDAC5 histone deacetylase 5
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HIST1H2BC histone cluster 1, H2bc
HOXC11 homeobox C11
HOXC13 homeobox C13
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
IGFLR1 IGF-like family receptor 1
ITPKB inositol-trisphosphate 3-kinase B
KAT2A K(lysine) acetyltransferase 2A
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4
KIAA0319L KIAA0319-like
KIF18B kinesin family member 18B
LGR4 leucine-rich repeat containing G protein-coupled receptor 4
LINC00115 long intergenic non-protein coding RNA 115
LOC257152 uncharacterized LOC257152
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1
LY6G5C lymphocyte antigen 6 complex, locus G5C
MAP3K6 mitogen-activated protein kinase kinase kinase 6
MAP6D1 MAP6 domain containing 1
MPI mannose phosphate isomerase
MUC3A mucin 3A, cell surface associated
NOL12 nucleolar protein 12
NOTCH1 notch 1
NT5DC3 5'-nucleotidase domain containing 3
NT5E 5'-nucleotidase, ecto (CD73)
NUP62CL nucleoporin 62kDa C-terminal like
P2RY2 purinergic receptor P2Y, G-protein coupled, 2
P3H4 prolyl 3-hydroxylase family member 4 (non-enzymatic)
PCSK7 proprotein convertase subtilisin/kexin type 7
PDK1 pyruvate dehydrogenase kinase, isozyme 1
PFAS phosphoribosylformylglycinamidine synthase
PP14571 uncharacterized LOC100130449
PPM1F protein phosphatase, Mg2+/Mn2+ dependent, 1F
PRKCD protein kinase C, delta
PRKX protein kinase, X-linked
PRPH peripherin
PRR15L proline rich 15-like
QTRT1 queuine tRNA-ribosyltransferase 1
RAB3A RAB3A, member RAS oncogene family
RANGRF RAN guanine nucleotide release factor
RFTN1 raftlin, lipid raft linker 1
RGS16 regulator of G-protein signaling 16
RHBDF1 rhomboid 5 homolog 1 (Drosophila)
RHPN1-AS1 RHPN1 antisense RNA 1 (head to head)
RRAGB Ras-related GTP binding B
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SGCE sarcoglycan, epsilon
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein)
SLC27A6 solute carrier family 27 (fatty acid transporter), member 6
SLC4A2 solute carrier family 4 (anion exchanger), member 2
SLC6A14 solute carrier family 6 (amino acid transporter), member 14
SREBF1 sterol regulatory element binding transcription factor 1
STARD13 StAR-related lipid transfer (START) domain containing 13
TARP TCR gamma alternate reading frame protein
THNSL1 threonine synthase-like 1 (S. cerevisiae)
TMEM39B transmembrane protein 39B
TMEM51 transmembrane protein 51
TPK1 thiamin pyrophosphokinase 1
TRPV1 transient receptor potential cation channel, subfamily V, member 1
USP5 ubiquitin specific peptidase 5 (isopeptidase T)
VEGFC vascular endothelial growth factor C
WDR6 WD repeat domain 6
ZNF219 zinc finger protein 219
ZNF446 zinc finger protein 446