15-delta prostaglandin J2-4455 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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Genes

199 genes differentially expressed following the 15-delta prostaglandin J2-4455 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase
ACTN2 actinin, alpha 2
ADM adrenomedullin
ADRB2 adrenoceptor beta 2, surface
AEN apoptosis enhancing nuclease
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
AMIGO2 adhesion molecule with Ig-like domain 2
ANGPTL2 angiopoietin-like 2
ANGPTL4 angiopoietin-like 4
ATF3 activating transcription factor 3
BTF3P11 basic transcription factor 3 pseudogene 11
CCNK cyclin K
CD52 CD52 molecule
CD53 CD53 molecule
CDH7 cadherin 7, type 2
CDHR2 cadherin-related family member 2
CETP cholesteryl ester transfer protein, plasma
CNPY4 canopy FGF signaling regulator 4
CRYAB crystallin, alpha B
CXCL3 chemokine (C-X-C motif) ligand 3
CYP2C9 cytochrome P450, family 2, subfamily C, polypeptide 9
DCAF13 DDB1 and CUL4 associated factor 13
DDR1-AS1 DDR1 antisense RNA 1 (head to head)
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
DKFZP434C153 DKFZP434C153 protein
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DUSP1 dual specificity phosphatase 1
EDRF1 erythroid differentiation regulatory factor 1
ELOVL4 ELOVL fatty acid elongase 4
FABP4 fatty acid binding protein 4, adipocyte
FBXL18 F-box and leucine-rich repeat protein 18
FGF1 fibroblast growth factor 1 (acidic)
FUT5 fucosyltransferase 5 (alpha (1,3) fucosyltransferase)
GABARAPL1 GABA(A) receptor-associated protein like 1
GCNT3 glucosaminyl (N-acetyl) transferase 3, mucin type
HMOX1 heme oxygenase 1
HSPA12A heat shock 70kDa protein 12A
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB8 heat shock 22kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IRS2 insulin receptor substrate 2
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)
ITGA7 integrin, alpha 7
JUN jun proto-oncogene
KAZN kazrin, periplakin interacting protein
KCNH2 potassium channel, voltage gated eag related subfamily H, member 2
KIF25-AS1 KIF25 antisense RNA 1
KIF5C kinesin family member 5C
KLHL22 kelch-like family member 22
LAMA4 laminin, alpha 4
LDHC lactate dehydrogenase C
LMTK2 lemur tyrosine kinase 2
LOC202181 SUMO-interacting motifs containing 1 pseudogene
LPIN1 lipin 1
LYPD3 LY6/PLAUR domain containing 3
NBR2 neighbor of BRCA1 gene 2 (non-protein coding)
NCF4 neutrophil cytosolic factor 4, 40kDa
NDUFA2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 2, 8kDa
NF1 neurofibromin 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
OSGIN1 oxidative stress induced growth inhibitor 1
PAPOLA poly(A) polymerase alpha
PDE4DIP phosphodiesterase 4D interacting protein
PIM1 Pim-1 proto-oncogene, serine/threonine kinase
PLIN2 perilipin 2
PLP1 proteolipid protein 1
PTGER3 prostaglandin E receptor 3 (subtype EP3)
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RAB6A RAB6A, member RAS oncogene family
RAVER2 ribonucleoprotein, PTB-binding 2
REPS1 RALBP1 associated Eps domain containing 1
RGCC regulator of cell cycle
RHOB ras homolog family member B
RND1 Rho family GTPase 1
RUNDC3A RUN domain containing 3A
SLC48A1 solute carrier family 48 (heme transporter), member 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMAD6 SMAD family member 6
SMPD2 sphingomyelin phosphodiesterase 2, neutral membrane (neutral sphingomyelinase)
SOCS7 suppressor of cytokine signaling 7
SORBS1 sorbin and SH3 domain containing 1
SPRR2B small proline-rich protein 2B
SQSTM1 sequestosome 1
STK17B serine/threonine kinase 17b
TAF7L TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa
TGM4 transglutaminase 4
TMEM74B transmembrane protein 74B
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TPM3 tropomyosin 3
UNKL unkempt family zinc finger-like
WDR1 WD repeat domain 1
WRNIP1 Werner helicase interacting protein 1
ZNF516 zinc finger protein 516

decreased expression

Symbol Name
ACBD4 acyl-CoA binding domain containing 4
ADGRB2 adhesion G protein-coupled receptor B2
AFAP1 actin filament associated protein 1
ALPK1 alpha-kinase 1
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like
ARMCX2 armadillo repeat containing, X-linked 2
ARSB arylsulfatase B
ATAD5 ATPase family, AAA domain containing 5
B3GALT4 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4
BFSP1 beaded filament structural protein 1, filensin
BHLHE40 basic helix-loop-helix family, member e40
C1QTNF3 C1q and tumor necrosis factor related protein 3
C6ORF47 chromosome 6 open reading frame 47
CCDC85C coiled-coil domain containing 85C
CCNJL cyclin J-like
CCP110 centriolar coiled coil protein 110kDa
CDKN2D cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)
CLDN11 claudin 11
CSRNP3 cysteine-serine-rich nuclear protein 3
CTDP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) phosphatase, subunit 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
DDN dendrin
DNAH7 dynein, axonemal, heavy chain 7
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
FAM131B family with sequence similarity 131, member B
FZD8 frizzled class receptor 8
GIT1 G protein-coupled receptor kinase interacting ArfGAP 1
GNA14 guanine nucleotide binding protein (G protein), alpha 14
GPRIN2 G protein regulated inducer of neurite outgrowth 2
GRPR gastrin-releasing peptide receptor
GTF2A1 general transcription factor IIA, 1, 19/37kDa
GTF2I general transcription factor IIi
H1F0 H1 histone family, member 0
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IGFLR1 IGF-like family receptor 1
IL12RB1 interleukin 12 receptor, beta 1
IL1RAPL2 interleukin 1 receptor accessory protein-like 2
IL33 interleukin 33
INCENP inner centromere protein antigens 135/155kDa
INPP5J inositol polyphosphate-5-phosphatase J
INPPL1 inositol polyphosphate phosphatase-like 1
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
JAK2 Janus kinase 2
KCTD15 potassium channel tetramerization domain containing 15
KLHL29 kelch-like family member 29
LHPP phospholysine phosphohistidine inorganic pyrophosphate phosphatase
LMNB1 lamin B1
LMO7 LIM domain 7
LOC730101 uncharacterized LOC730101
MDFI MyoD family inhibitor
MVD mevalonate (diphospho) decarboxylase
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta
NPY1R neuropeptide Y receptor Y1
NR3C2 nuclear receptor subfamily 3, group C, member 2
ODF2 outer dense fiber of sperm tails 2
PADI1 peptidyl arginine deiminase, type I
PAIP2B poly(A) binding protein interacting protein 2B
PALMD palmdelphin
PAQR6 progestin and adipoQ receptor family member VI
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4
PLAT plasminogen activator, tissue
PLD2 phospholipase D2
PLSCR2 phospholipid scramblase 2
POLM polymerase (DNA directed), mu
POU3F2 POU class 3 homeobox 2
PQLC2 PQ loop repeat containing 2
PRKG2 protein kinase, cGMP-dependent, type II
PRR15L proline rich 15-like
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)
RGS2 regulator of G-protein signaling 2
RNF122 ring finger protein 122
RNF43 ring finger protein 43
SEMA4A sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SETD1A SET domain containing 1A
SIRT6 sirtuin 6
SLC22A14 solute carrier family 22, member 14
SMA4 glucuronidase, beta pseudogene
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SPTBN2 spectrin, beta, non-erythrocytic 2
ST5 suppression of tumorigenicity 5
TAB1 TGF-beta activated kinase 1/MAP3K7 binding protein 1
TAGLN transgelin
TAGLN3 transgelin 3
TCEAL2 transcription elongation factor A (SII)-like 2
TLR1 toll-like receptor 1
TMEM19 transmembrane protein 19
TNS2 tensin 2
TRAIP TRAF interacting protein
UNC93B1 unc-93 homolog B1 (C. elegans)
VEGFB vascular endothelial growth factor B
VGF VGF nerve growth factor inducible
WNT16 wingless-type MMTV integration site family, member 16
ZNF428 zinc finger protein 428
ZNF446 zinc finger protein 446