11-deoxy-16,16-dimethylprostaglandin E2-7514 Gene Set

Dataset CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [small molecule name]-[perturbation ID] (ChIP-X Enrichment Analysis)
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193 genes differentially expressed following the 11-deoxy-16,16-dimethylprostaglandin E2-7514 small molecule perturbation from the CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ABCB8 ATP-binding cassette, sub-family B (MDR/TAP), member 8
ACAN aggrecan
ACTG2 actin, gamma 2, smooth muscle, enteric
ADAP2 ArfGAP with dual PH domains 2
AKAP8L A kinase (PRKA) anchor protein 8-like
AKR1C1 aldo-keto reductase family 1, member C1
APOE apolipoprotein E
ARHGDIA Rho GDP dissociation inhibitor (GDI) alpha
ARMC4 armadillo repeat containing 4
ARSD arylsulfatase D
BCL2 B-cell CLL/lymphoma 2
CACTIN cactin, spliceosome C complex subunit
CD3D CD3d molecule, delta (CD3-TCR complex)
CD6 CD6 molecule
CHST10 carbohydrate sulfotransferase 10
CIDEC cell death-inducing DFFA-like effector c
CLSPN claspin
CSF1R colony stimulating factor 1 receptor
CSHL1 chorionic somatomammotropin hormone-like 1
CXORF21 chromosome X open reading frame 21
CYB561 cytochrome b561
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4
CYTH4 cytohesin 4
DCAKD dephospho-CoA kinase domain containing
DHRS12 dehydrogenase/reductase (SDR family) member 12
EDN3 endothelin 3
EMID1 EMI domain containing 1
ENTPD3 ectonucleoside triphosphate diphosphohydrolase 3
EPHA2 EPH receptor A2
ERN2 endoplasmic reticulum to nucleus signaling 2
EZR ezrin
FOXN2 forkhead box N2
GABBR1 gamma-aminobutyric acid (GABA) B receptor, 1
GALK1 galactokinase 1
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GLUD2 glutamate dehydrogenase 2
HAMP hepcidin antimicrobial peptide
HCRP1 hepatocellular carcinoma-related HCRP1
HECW1 HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
HK2 hexokinase 2
HTR1F 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled
IFI35 interferon-induced protein 35
IFNA14 interferon, alpha 14
IGFBP3 insulin-like growth factor binding protein 3
IGHMBP2 immunoglobulin mu binding protein 2
INPP5J inositol polyphosphate-5-phosphatase J
IRF1 interferon regulatory factor 1
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KIF1A kinesin family member 1A
KLF6 Kruppel-like factor 6
KRTAP5-8 keratin associated protein 5-8
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1
LRRC23 leucine rich repeat containing 23
MAN2A2 mannosidase, alpha, class 2A, member 2
MAPK7 mitogen-activated protein kinase 7
MED27 mediator complex subunit 27
MEF2A myocyte enhancer factor 2A
MFAP5 microfibrillar associated protein 5
MFGE8 milk fat globule-EGF factor 8 protein
MPP6 membrane protein, palmitoylated 6 (MAGUK p55 subfamily member 6)
MRPL44 mitochondrial ribosomal protein L44
MSL3 male-specific lethal 3 homolog (Drosophila)
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle
NF2 neurofibromin 2 (merlin)
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon
NLRX1 NLR family member X1
NR4A1 nuclear receptor subfamily 4, group A, member 1
OCRL oculocerebrorenal syndrome of Lowe
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2
PADI4 peptidyl arginine deiminase, type IV
PDE10A phosphodiesterase 10A
PEX16 peroxisomal biogenesis factor 16
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5
PIM2 Pim-2 proto-oncogene, serine/threonine kinase
PLEKHO2 pleckstrin homology domain containing, family O member 2
POLDIP3 polymerase (DNA-directed), delta interacting protein 3
PPP1R37 protein phosphatase 1, regulatory subunit 37
PSMD9 proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
PTCRA pre T-cell antigen receptor alpha
PTPRS protein tyrosine phosphatase, receptor type, S
RANBP1 RAN binding protein 1
RARS arginyl-tRNA synthetase
RRP1B ribosomal RNA processing 1B
SLC6A16 solute carrier family 6, member 16
SOCS2 suppressor of cytokine signaling 2
SWAP70 SWAP switching B-cell complex 70kDa subunit
SYCP2 synaptonemal complex protein 2
TJAP1 tight junction associated protein 1 (peripheral)
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B
TRIO trio Rho guanine nucleotide exchange factor
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TTC12 tetratricopeptide repeat domain 12
UBN1 ubinuclein 1
VIPR1 vasoactive intestinal peptide receptor 1
ZBED4 zinc finger, BED-type containing 4

decreased expression

Symbol Name
ABHD4 abhydrolase domain containing 4
ACTR8 ARP8 actin-related protein 8 homolog (yeast)
AFAP1 actin filament associated protein 1
ARHGAP5 Rho GTPase activating protein 5
ARNTL2 aryl hydrocarbon receptor nuclear translocator-like 2
ASB9 ankyrin repeat and SOCS box containing 9
ATAD5 ATPase family, AAA domain containing 5
ATAT1 alpha tubulin acetyltransferase 1
ATP8B2 ATPase, aminophospholipid transporter, class I, type 8B, member 2
BAGE B melanoma antigen
BAHCC1 BAH domain and coiled-coil containing 1
BCAS1 breast carcinoma amplified sequence 1
BEGAIN brain-enriched guanylate kinase-associated
C17ORF53 chromosome 17 open reading frame 53
CASD1 CAS1 domain containing 1
CCBL1 cysteine conjugate-beta lyase, cytoplasmic
CCDC176 coiled-coil domain containing 176
CCZ1B CCZ1 vacuolar protein trafficking and biogenesis associated homolog B (S. cerevisiae)
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
CLDND1 claudin domain containing 1
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4
CORT cortistatin
CRYBG3 beta-gamma crystallin domain containing 3
CWC25 CWC25 spliceosome-associated protein homolog (S. cerevisiae)
DNAL4 dynein, axonemal, light chain 4
DSCAM Down syndrome cell adhesion molecule
EFNA3 ephrin-A3
ERCC2 excision repair cross-complementation group 2
FAM63A family with sequence similarity 63, member A
FOXD1 forkhead box D1
GBAS glioblastoma amplified sequence
GDAP2 ganglioside induced differentiation associated protein 2
GJA1 gap junction protein, alpha 1, 43kDa
GMEB1 glucocorticoid modulatory element binding protein 1
GPR68 G protein-coupled receptor 68
GTF2H2B general transcription factor IIH, polypeptide 2B (pseudogene)
HOXC5 homeobox C5
HTR1E 5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
INF2 inverted formin, FH2 and WH2 domain containing
ITPKB inositol-trisphosphate 3-kinase B
KLK8 kallikrein-related peptidase 8
LOC257152 uncharacterized LOC257152
LTC4S leukotriene C4 synthase
LYPLA2P1 lysophospholipase II pseudogene 1
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAP9 microtubule-associated protein 9
MEX3C mex-3 RNA binding family member C
MT3 metallothionein 3
MTCL1 microtubule crosslinking factor 1
MVD mevalonate (diphospho) decarboxylase
MYO1E myosin IE
NOTCH4 notch 4
OPLAH 5-oxoprolinase (ATP-hydrolysing)
PAQR6 progestin and adipoQ receptor family member VI
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PIGB phosphatidylinositol glycan anchor biosynthesis, class B
PIGH phosphatidylinositol glycan anchor biosynthesis, class H
PLCD1 phospholipase C, delta 1
RAB36 RAB36, member RAS oncogene family
RAB3A RAB3A, member RAS oncogene family
RFX7 regulatory factor X, 7
RGS17 regulator of G-protein signaling 17
RPE ribulose-5-phosphate-3-epimerase
RPGR retinitis pigmentosa GTPase regulator
RSF1 remodeling and spacing factor 1
RUSC2 RUN and SH3 domain containing 2
SAMHD1 SAM domain and HD domain 1
SCAI suppressor of cancer cell invasion
SCYL2 SCY1-like 2 (S. cerevisiae)
SEC61A2 Sec61 alpha 2 subunit (S. cerevisiae)
SETD8 SET domain containing (lysine methyltransferase) 8
SIPA1 signal-induced proliferation-associated 1
SLC25A23 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 23
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1
SMPDL3B sphingomyelin phosphodiesterase, acid-like 3B
SNX15 sorting nexin 15
SPAG4 sperm associated antigen 4
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
TBC1D2 TBC1 domain family, member 2
TCP10 t-complex 10
TMEM30A transmembrane protein 30A
TMEM53 transmembrane protein 53
TMEM62 transmembrane protein 62
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae)
TTC28 tetratricopeptide repeat domain 28
USP20 ubiquitin specific peptidase 20
WWC2 WW and C2 domain containing 2
YAF2 YY1 associated factor 2
YIF1B Yip1 interacting factor homolog B (S. cerevisiae)
ZBED8 zinc finger, BED-type containing 8
ZBTB22 zinc finger and BTB domain containing 22
ZFP30 ZFP30 zinc finger protein
ZMAT5 zinc finger, matrin-type 5
ZNF140 zinc finger protein 140
ZNF219 zinc finger protein 219
ZNF76 zinc finger protein 76