|HGNC Family||T cell receptors (TR)|
|Name||T cell receptor gamma locus|
|Description||T cell receptors recognize foreign antigens which have been processed as small peptides and bound to major histocompatibility complex (MHC) molecules at the surface of antigen presenting cells (APC). Each T cell receptor is a dimer consisting of one alpha and one beta chain or one delta and one gamma chain. In a single cell, the T cell receptor loci are rearranged and expressed in the order delta, gamma, beta, and alpha. If both delta and gamma rearrangements produce functional chains, the cell expresses delta and gamma. If not, the cell proceeds to rearrange the beta and alpha loci. This region represents the germline organization of the T cell receptor gamma locus. The gamma locus includes V (variable), J (joining), and C (constant) segments. During T cell development, the gamma chain is synthesized by a recombination event at the DNA level joining a V segment with a J segment; the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random addition of nucleotides by terminal deoxynucleotidyltransferase. Several V segments of the gamma locus are known to be incapable of encoding a protein and are considered pseudogenes. Somatic rearrangement of the gamma locus has been observed in T cells derived from patients with T cell leukemia and ataxia telangiectasia. [provided by RefSeq, Jul 2008]|
|NCBI Gene ID||6965|
|Expression in Tissues and Cell Lines||
TRG has 349 functional associations with biological entities spanning 4 categories (disease, phenotype or trait, functional term, phrase or reference, cell line, cell type or tissue, gene, protein or microRNA) extracted from 7 datasets.
Click the + buttons to view associations for TRG from the datasets below.
If available, associations are ranked by standardized value
|BioGPS Human Cell Type and Tissue Gene Expression Profiles||cell types and tissues with high or low expression of TRG gene relative to other cell types and tissues from the BioGPS Human Cell Type and Tissue Gene Expression Profiles dataset.|
|dbGAP Gene-Trait Associations||traits associated with TRG gene in GWAS and other genetic association datasets from the dbGAP Gene-Trait Associations dataset.|
|GAD Gene-Disease Associations||diseases associated with TRG gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.|
|GAD High Level Gene-Disease Associations||diseases associated with TRG gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.|
|GeneRIF Biological Term Annotations||biological terms co-occuring with TRG gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.|
|Hub Proteins Protein-Protein Interactions||interacting hub proteins for TRG from the curated Hub Proteins Protein-Protein Interactions dataset.|
|HuGE Navigator Gene-Phenotype Associations||phenotypes associated with TRG gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.|