|HGNC Family||Non-coding RNAs|
|Name||RNA, U2 small nuclear 1|
|Description||The spliceosome is a multicomponent ribonucleoprotein complex that catalyzes the removal of introns from nuclear mRNA precursors. The spliceosome is composed of four small ribonucleoprotein particles (the U1, U2, and U4/U6 snRNPs) and numerous additional proteins. The U2 small nuclear RNA (snRNA) is a RNA component of the U2 snRNP that interacts with the 3' region of the intron at the branch site. Several sites in the human genome express U2 snRNAs. This locus represents an array of U2 snRNA genes located at 17q21-22 that undergoes concerted evolution to homogenize repeat units within the array. Each repeat in this array is approximately 6.1 kb long and contains a single copy of the U2 snRNA. Arrays of six to more than 30 repeats have been reported. [provided by RefSeq, Mar 2009]|
|NCBI Gene ID||6066|
|Expression in Tissues and Cell Lines||
RNU2-1 has 267 functional associations with biological entities spanning 2 categories (functional term, phrase or reference, cell line, cell type or tissue) extracted from 5 datasets.
Click the + buttons to view associations for RNU2-1 from the datasets below.
If available, associations are ranked by standardized value
|ESCAPE Omics Signatures of Genes and Proteins for Stem Cells||PubMedIDs of publications reporting gene signatures containing RNU2-1 from the ESCAPE Omics Signatures of Genes and Proteins for Stem Cells dataset.|
|GeneRIF Biological Term Annotations||biological terms co-occuring with RNU2-1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.|
|Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles||cell lines with high or low copy number of RNU2-1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.|
|Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles||cell lines with high or low expression of RNU2-1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene Expression Profiles dataset.|
|Wikipathways Pathways||pathways involving RNU2-1 protein from the Wikipathways Pathways dataset.|