|Name||protocadherin gamma cluster|
|Description||The protocadherin gamma gene cluster is one of three related clusters tandemly linked on chromosome five. The clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma cluster includes 22 genes divided into 3 subfamilies, all part of the cadherin superfamily. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. In addition, ORNT2 and TAF2F are included in the cluster due to their localization between protocadherin clusters beta and gamma on chromosome five. The protocadherin genes are organized in a tandem array of 22 large, variable region exons followed by a constant region, which contains 3 exons shared by all protocadherin genes in the cluster. Each variable region exon encodes an extracellular domain comprised of 6 cadherin ectodomains and a transmembrane region. The constant region exons encode a common cytoplasmic tail. These neural adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes. [provided by RefSeq, Jul 2008]|
|NCBI Gene ID||56115|
|Expression in Tissues and Cell Lines||
PCDHG@ has 181 functional associations with biological entities spanning 5 categories (molecular profile, functional term, phrase or reference, disease, phenotype or trait, cell line, cell type or tissue, gene, protein or microRNA) extracted from 9 datasets.
Click the + buttons to view associations for PCDHG@ from the datasets below.
If available, associations are ranked by standardized value
|CHEA Transcription Factor Binding Site Profiles||transcription factor binding site profiles with transcription factor binding evidence at the promoter of PCDHG@ gene from the CHEA Transcription Factor Binding Site Profiles dataset.|
|CHEA Transcription Factor Targets||transcription factors binding the promoter of PCDHG@ gene in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.|
|COMPARTMENTS Curated Protein Localization Evidence Scores||cellular components containing PCDHG@ protein from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.|
|COSMIC Cell Line Gene Mutation Profiles||cell lines with PCDHG@ gene mutations from the COSMIC Cell Line Gene Mutation Profiles dataset.|
|DISEASES Text-mining Gene-Disease Assocation Evidence Scores||diseases co-occuring with PCDHG@ gene in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores dataset.|
|GeneRIF Biological Term Annotations||biological terms co-occuring with PCDHG@ gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.|
|TISSUES Curated Tissue Protein Expression Evidence Scores||tissues with high expression of PCDHG@ protein from the TISSUES Curated Tissue Protein Expression Evidence Scores dataset.|
|TISSUES Experimental Tissue Protein Expression Evidence Scores||tissues with high expression of PCDHG@ protein in proteomics datasets from the TISSUES Experimental Tissue Protein Expression Evidence Scores dataset.|
|TISSUES Text-mining Tissue Protein Expression Evidence Scores||tissues co-occuring with PCDHG@ protein in abstracts of biomedical publications from the TISSUES Text-mining Tissue Protein Expression Evidence Scores dataset.|