|Description||microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]|
|NCBI Gene ID||100847084|
|Expression in Tissues and Cell Lines||
MIR548AP has 172 functional associations with biological entities spanning 3 categories (disease, phenotype or trait, cell line, cell type or tissue, gene, protein or microRNA) extracted from 6 datasets.
Click the + buttons to view associations for MIR548AP from the datasets below.
If available, associations are ranked by standardized value
|CCLE Cell Line Gene CNV Profiles||cell lines with high or low copy number of MIR548AP gene relative to other cell lines from the CCLE Cell Line Gene CNV Profiles dataset.|
|COSMIC Cell Line Gene CNV Profiles||cell lines with high or low copy number of MIR548AP gene relative to other cell lines from the COSMIC Cell Line Gene CNV Profiles dataset.|
|GWAS Catalog SNP-Phenotype Associations||phenotypes associated with MIR548AP gene in GWAS datasets from the GWAS Catalog SNP-Phenotype Associations dataset.|
|Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles||cell lines with high or low copy number of MIR548AP gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.|
|MotifMap Predicted Transcription Factor Targets||transcription factors regulating expression of MIR548AP gene predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.|
|Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles||cell types and tissues with high or low DNA methylation of MIR548AP gene relative to other cell types and tissues from the Roadmap Epigenomics Cell and Tissue DNA Methylation Profiles dataset.|