MIR378A Gene

HGNC Family Non-coding RNAs
Name microRNA 378a
Description microRNAs (miRNAs) are short (20-24 nt) non-coding RNAs that are involved in post-transcriptional regulation of gene expression in multicellular organisms by affecting both the stability and translation of mRNAs. miRNAs are transcribed by RNA polymerase II as part of capped and polyadenylated primary transcripts (pri-miRNAs) that can be either protein-coding or non-coding. The primary transcript is cleaved by the Drosha ribonuclease III enzyme to produce an approximately 70-nt stem-loop precursor miRNA (pre-miRNA), which is further cleaved by the cytoplasmic Dicer ribonuclease to generate the mature miRNA and antisense miRNA star (miRNA*) products. The mature miRNA is incorporated into a RNA-induced silencing complex (RISC), which recognizes target mRNAs through imperfect base pairing with the miRNA and most commonly results in translational inhibition or destabilization of the target mRNA. The RefSeq represents the predicted microRNA stem-loop. [provided by RefSeq, Sep 2009]
Synonyms HSA-MIR-378A, MIRNA378, HSA-MIR-378, MIRN378, MIR378
NCBI Gene ID 494327
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Predicted Functions View MIR378A's ARCHS4 Predicted Functions.
Co-expressed Genes View MIR378A's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View MIR378A's ARCHS4 Predicted Functions.

Functional Associations

MIR378A has 351 functional associations with biological entities spanning 5 categories (disease, phenotype or trait, functional term, phrase or reference, chemical, cell line, cell type or tissue, gene, protein or microRNA) extracted from 9 datasets.

Click the + buttons to view associations for MIR378A from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
CTD Gene-Disease Associations diseases associated with MIR378A gene/protein from the curated CTD Gene-Disease Associations dataset.
GeneRIF Biological Term Annotations biological terms co-occuring with MIR378A gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
GeneSigDB Published Gene Signatures PubMedIDs of publications reporting gene signatures containing MIR378A from the GeneSigDB Published Gene Signatures dataset.
GEO Signatures of Differentially Expressed Genes for Small Molecules small molecule perturbations changing expression of MIR378A gene from the GEO Signatures of Differentially Expressed Genes for Small Molecules dataset.
HuGE Navigator Gene-Phenotype Associations phenotypes associated with MIR378A gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of MIR378A gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
MPO Gene-Phenotype Associations phenotypes of transgenic mice caused by MIR378A gene mutations from the MPO Gene-Phenotype Associations dataset.
TRANSFAC Curated Transcription Factor Targets transcription factors binding the promoter of MIR378A gene in low- or high-throughput transcription factor functional studies from the TRANSFAC Curated Transcription Factor Targets dataset.
Wikipathways Pathways pathways involving MIR378A protein from the Wikipathways Pathways dataset.