DUX4L1 Gene

HGNC Family Homeoboxes
Name double homeobox 4 like 1
Description This gene is located within a D4Z4 repeat array in the subtelomeric region of chromosome 4q. The D4Z4 repeat is polymorphic in length and a similar D4Z4 repeat array has been identified on chromosome 10. Each D4Z4 repeat unit has an open reading frame (named DUX4) that encodes two homeoboxes; the repeat-array and ORF is conserved in other mammals. There is no evidence for transcription of the gene at this locus though RT-PCR and in vitro expression experiments indicate that a telomeric paralog of this gene is transcribed in some haplotypes. Contraction of the macrosatellite repeat causes autosomal dominant facioscapulohumeral muscular dystrophy (FSHD). [provided by RefSeq, Jun 2014]
Synonyms DUX10
NCBI Gene ID 22947
API
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Predicted Functions View DUX4L1's ARCHS4 Predicted Functions.
Co-expressed Genes View DUX4L1's ARCHS4 Predicted Functions.
Expression in Tissues and Cell Lines View DUX4L1's ARCHS4 Predicted Functions.

Functional Associations

DUX4L1 has 380 functional associations with biological entities spanning 2 categories (functional term, phrase or reference, cell line, cell type or tissue) extracted from 4 datasets.

Click the + buttons to view associations for DUX4L1 from the datasets below.

If available, associations are ranked by standardized value

Dataset Summary
GeneRIF Biological Term Annotations biological terms co-occuring with DUX4L1 gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.
Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles cell lines with high or low copy number of DUX4L1 gene relative to other cell lines from the Klijn et al., Nat. Biotechnol., 2015 Cell Line Gene CNV Profiles dataset.
LOCATE Curated Protein Localization Annotations cellular components containing DUX4L1 protein in low- or high-throughput protein localization assays from the LOCATE Curated Protein Localization Annotations dataset.
LOCATE Predicted Protein Localization Annotations cellular components predicted to contain DUX4L1 protein from the LOCATE Predicted Protein Localization Annotations dataset.