|HGNC Family||Cytochrome P450s (CYP)|
|Name||cytochrome P450, family 3, subfamily A|
|Description||The CYP3A locus includes all the known members of the 3A subfamily of the cytochrome P450 superfamily of genes. These genes encode monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The CYP3A cluster consists of four genes, CYP3A43, CYP3A4, CYP3A7 and CYP3A5. The region also contains two pseudogenes, CYP3A5P1 and CYP3A5P2, as well as several extra exons which may or may not be included in transcripts produced from this region. Previously another CYP3A member, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. [provided by RefSeq, Jul 2008]|
|NCBI Gene ID||1574|
|Expression in Tissues and Cell Lines||
CYP3A has 709 functional associations with biological entities spanning 3 categories (functional term, phrase or reference, chemical, disease, phenotype or trait) extracted from 7 datasets.
Click the + buttons to view associations for CYP3A from the datasets below.
If available, associations are ranked by standardized value
|Biocarta Pathways||pathways involving CYP3A protein from the Biocarta Pathways dataset.|
|CTD Gene-Chemical Interactions||chemicals interacting with CYP3A gene/protein from the curated CTD Gene-Chemical Interactions dataset.|
|CTD Gene-Disease Associations||diseases associated with CYP3A gene/protein from the curated CTD Gene-Disease Associations dataset.|
|GAD Gene-Disease Associations||diseases associated with CYP3A gene in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.|
|GAD High Level Gene-Disease Associations||diseases associated with CYP3A gene in GWAS and other genetic association datasets from the GAD High Level Gene-Disease Associations dataset.|
|GeneRIF Biological Term Annotations||biological terms co-occuring with CYP3A gene in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.|
|HuGE Navigator Gene-Phenotype Associations||phenotypes associated with CYP3A gene by text-mining GWAS publications from the HuGE Navigator Gene-Phenotype Associations dataset.|