Pathway Generator
The PathwayGenerator (PG) web-interface was created using the mammalian neuronal cell signaling
network extracted from literature by
Avi Ma'ayan and members of the
Iyengar lab at
Mount Sinai School of Medicine between 2003 and 2006. A
paper describing the topology of this network was published in
Science in 2005. The network contains mostly directed and signed links (i.e. activation/inhibition with source and target nodes specified).
Using
Dijkstra's shortest path algorithm, we searched for pathways starting from ligand-receptor interactions to reach effector proteins in a limited number of steps. The search was directed such that the flow must follow the orientation of the arrows. In total, approximately 5,000 pathways were created and can be visualized here. An implementation of the algorithm is provided with the
SNAVI source code. If you wish to create a similar web-based interface for a different network, this can be achieved with
SNAVI, published in
BMC Systems Biology in 2009. Thank you for trying PG.
Please choose a pathway option:
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