HEXIM1 Induction Analysis in A375 Melanoma Cell Line | BioJupies

Notebook Generator(s): Julia Zhao, Kevin Moses, Denis Torre, Avi Ma'ayan
Collection No.2

Citation: Zhao, J., Moses, K., Torre, D., and Ma’ayan, A. (2018). BioJupies Notebook for HEXIM1 Induction Analysis in A375 Melanoma Cell Line. Journal of Interactive Notebooks Collection 2, 57.

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This notebook uses the BioJupies Jupyter Notebook Generator to analyze GEO Dataset GSE68040, which tests a knockin perturbation of HEXIM1 on tumor growth rates in the A375 melanoma cell line with a doxycycline diet. Gene Ontology Enrichment Analysis (GO) shows slight down-regulation of epithelial morphogenesis and hormone activity, and Pathway Enrichment Analysis suggests up-regulation various infections and GCPR pathways. In addition to Library Size and Differential Expression Analysis, BioJupies provides further analysis via Kinase Enrichment and miRNA Enrichment, as well as L1000CDS Small Molecule Query. Visualization tools such as L1000FWD, PCA, and a Clustergrammer interactive heat map is also provided.