Histone H3.3 Knockout with p53 in Mouse Embryonic Fibroblast Cells | Biojupies


Notebook Generator(s): Rachel Werner, Kevin Moses, Denis Torre, Avi Ma'ayan
Posted:2018-07-24
Collection No.1

Citation: Werner, R., Moses, K., Torre, D., and Ma’ayan, A. (2018). BioJupies Notebook for Histone H3.3 Knockout with p53 in Mouse Embryonic Fibroblast Cells. Journal of Interactive Notebooks Collection 1, 51.

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This notebook, generated by the BioJupies Jupyter Notebeook Generator, analyzes GEO Dataset GSE69771 with knockout of Histone H3.3 in mouse embryonic fibroblast cells. Using BioJupies' Gene Ontology Enrichment Analysis, multiple toll-like receptor signaling pathways were noticeably down-regulated. This down-regulation can be seen with Volcano Plots as well as MA Plots and the Clustergrammer visualization tool. Transcription Factor Analysis further shows downregulation in genes such as IRF2, TFEC, and others involved in differentiation.