Source Location Target Location Effect Interaction Type PMID AKT1 cytosol GSK3B cytosol -1 Phosphorylation 17620314 AKT1 cytosol TBX3 nuclear 1 IndirectTranscription 19571885 COBRA1 nuclear LEF1 nuclear -1 TFPromoterBinding 19340312 CDX2 nuclear POU5F1 nuclear -1 TFPromoterBinding 16325584 CTR9 nuclear BMP4 extra 1 TFPromoterBinding 19345177 CTR9 nuclear ESRRB nuclear 1 TFPromoterBinding 19345177 CTR9 nuclear H3K4 nuclear 1 IndirectMethylation 19345177 CTR9 nuclear KLF4 nuclear 1 TFPromoterBinding 19345177 CTR9 nuclear NANOG nuclear 1 TFPromoterBinding 19345177 CTR9 nuclear POU5F1 nuclear 1 TFPromoterBinding 19345177 CTR9 nuclear SOX2 nuclear 1 TFPromoterBinding 19345177 CTR9 nuclear TCL1 nuclear 1 TFPromoterBinding 19345177 EGFR membrane NFKB1 nuclear 1 Indirectsignal 17901397 ESRRB nuclear NANOG nuclear 0 ProteinProtein 18957414 ESRRB nuclear POU5F1 nuclear 1 TFPromoterBinding 18957414 EZH1 nuclear HIST3H3 nuclear 0 Methylation 19026780 FOXD3 nuclear NANOG nuclear 1 TFPromoterBinding 16790525 FOXD3 nuclear POU5F1 nuclear 1 TFPromoterBinding 16790525 GRM5 membrane AKT1 cytosol -1 Indirectsignal 16987252 GRM5 membrane GSK3B cytosol -1 Indirectsignal 16987252 GRM5 membrane MYC nuclear 1 IndirectProteinLevel 16987252 GRM5 membrane PRKCA cytosol 1 Indirectsignal 16987252 GSK3B cytosol MYC nuclear -1 Phosphorylation 16987252 HDAC2 nuclear PTEN cytosol -1 TFPromoterBinding 19440552 HDAC2 nuclear SALL1 nuclear -1 TFPromoterBinding 19440552 IL6ST membrane JAK2 cytosol 0 ProteinProtein 19571885 IL6ST membrane LIFR membrane 0 ProteinProtein 19544440 IL6ST membrane PIK3CA cytosol 1 ProteinProtein/Phosphorylation 19544440 IL6ST membrane STAT3 nuclear 1 Phosphorylation 9649508 IL6ST membrane YES1 cytosol 1 ProteinProtein/Phosphorylation 19544440 IRS1 cytosol ID1 nuclear 1 IndirectProteinLevel 17620314 IRS1 cytosol ID2 nuclear 1 IndirectProteinLevel 17620314 IRS1 cytosol PIK3CA cytosol 1 SignalTransduction 17620314 IRS1 cytosol POU5F1 nuclear 1 IndirectTranscription 17620314 JAK2 cytosol IL6ST membrane 1 Phosphorylation 19571885 JAK2 cytosol STAT3 nuclear 1 Phosphorylation 19571885 JMJD1C nuclear HIST3H3 nuclear 0 Demethylation 17549425 KDM3A nuclear HIST3H3 nuclear 0 Demethylation 17938240 KDM4C nuclear HIST3H3 nuclear 0 Demethylation 17938240 KITLG extra KIT membrane 1 LigandProtein 16129412 KLF4 nuclear LEFTY1 extra 1 TFPromoterBinding 16954384 KLF4 nuclear POU5F1 nuclear 0 ProteinProtein 19816951 KLF4 nuclear SOX2 nuclear 1 TFPromoterBinding 19571885 KLF4 nuclear SOX2 nuclear 0 ProteinProtein 19816951 KLF5 nuclear FGF5 nuclear -1 TFPromoterBinding 18983969 KLF5 nuclear HDAC2 nuclear 0 ProteinProtein 18983969 KLF5 nuclear MTA2 nuclear 0 ProteinProtein 18983969 KLF5 nuclear TCL1 nuclear 1 TFPromoterBinding 18983969 LIF extra CEBPB nuclear 1 IndirectTranscription 19537196 LIF extra IL6ST membrane 1 LigandProtein 12529546 LIF extra IRS1 cytosol 1 IndirectSignal/IndirectProteinLevel 17620314 LIF extra LIFR membrane 1 LigandProtein 17360716 LIF extra MYC nuclear 1 IndirectTranscription 16987252 LIF extra PIK3CA cytosol 1 Indirectsignal 17620314 LIF extra STAT3 nuclear 1 Indirectsignal 17620314 LIFR membrane PIK3CA cytosol 1 ProteinProtein/Phosphorylation 19544440 LIFR membrane YES1 cytosol 1 ProteinProtein/Phosphorylation 19544440 LIN28 cytosol ZCCHC11 cytosol 0 ProteinProtein 19703396 LYAR nuclear NCL nuclear 0 ProteinProtein 19489080 MED12 nuclear NANOG nuclear 0 ProteinProtein 19036726 MYBL2 nuclear POU5F1 nuclear 1 TFPromoterBinding 18575582 MYC nuclear MIR141 nuclear 1 TFPromoterBinding 19745813 MYC nuclear MIR200 nuclear 1 TFPromoterBinding 19745813 MYC nuclear MIR429 nuclear 1 TFPromoterBinding 19745813 NANOG nuclear CCRN4L nuclear 1 TFPromoterBinding 19544440 NANOG nuclear CDX2 nuclear -1 TFPromoterBinding 19564890 NANOG nuclear CNNM1 nuclear 1 TFPromoterBinding 19544440 NANOG nuclear DACT1 nuclear 1 TFPromoterBinding 19544440 NANOG nuclear KLF4 nuclear 1 TFPromoterBinding 19544440 NANOG nuclear KLF5 nuclear 1 TFPromoterBinding 19544440 NANOG nuclear MTA1 nuclear 0 ProteinProtein 18454141 NANOG nuclear MTA2 nuclear 0 ProteinProtein 18454141 NANOG nuclear PIM1 nuclear 1 TFPromoterBinding 19544440 NANOG nuclear PML nuclear 0 ProteinProtein 18454140 NANOG nuclear POU5F1 nuclear 1 TFPromoterBinding 16790525 NANOG nuclear POU5F1 nuclear 1 TFPromoterBinding 16978048 NANOG nuclear REL nuclear 0 ProteinProtein 18223644 NANOG nuclear RELA nuclear 0 ProteinProtein 18223644 NANOG nuclear RELB nuclear 0 ProteinProtein 18223644 NANOG nuclear RGS16 cytosol 1 TFPromoterBinding 19544440 NANOG nuclear SALL4 nuclear 1 TFPromoterBinding 19544440 NANOG nuclear SGK nuclear 1 TFPromoterBinding 19544440 NANOG nuclear SIN3A nuclear 0 ProteinProtein 18454139 NANOG nuclear SMAD1 nuclear 0 ProteinProtein 16801560 NANOG nuclear SMAD7 nuclear 1 TFPromoterBinding 19544440 NANOG nuclear SOX2 nuclear 1 TFPromoterBinding 16978048 NANOG nuclear SPRY2 cytosol 1 TFPromoterBinding 19544440 NANOG nuclear STAT3 nuclear 1 TFPromoterBinding 19544440 NR0B1 nuclear NR0B1 nuclear 1 TFPromoterBinding 18358816 NR0B1 nuclear POU5F1 nuclear 1 TFPromoterBinding 18358816 NR0B1 nuclear REXO1 nuclear 1 TFPromoterBinding 18358816 NR0B1 nuclear SOX2 nuclear 1 TFPromoterBinding 18358816 NR5A2 nuclear POU5F1 nuclear 1 TFPromoterBinding 15831456 PAF1 nuclear POU5F1 nuclear 0 ProteinProtein 19821493 PAXIP1 nuclear HIST3H3 nuclear 0 Methylation 19544464 PIK3CA cytosol AKT1 cytosol 1 SignalTransduction 15328362 PIK3CA cytosol AKT1 cytosol 1 Phosphorylation 17620314 PIK3CA cytosol CRK cytosol 1 ProteinProtein 16129412 POU5F1 nuclear CDKN1A nuclear -1 TFPromoterBinding 19968627 POU5F1 nuclear CDX2 nuclear -1 TFPromoterBinding 16325584 POU5F1 nuclear CTCF nuclear 0 ProteinProtein 19536159 POU5F1 nuclear EED nuclear 1 TFPromoterBinding 18201968 POU5F1 nuclear FBXO15 nuclear 1 TFPromoterBinding 12665572 POU5F1 nuclear FGF4 extra 1 TFPromoterBinding 1723621 POU5F1 nuclear KDM3A nuclear 1 TFPromoterBinding 17938240 POU5F1 nuclear KDM4C nuclear 1 TFPromoterBinding 17938240 POU5F1 nuclear KLF2 nuclear 1 TFPromoterBinding 19951688 POU5F1 nuclear LEFTY1 extra 1 TFPromoterBinding 17324942 POU5F1 nuclear NANOG nuclear 1 TFPromoterBinding 15860457 POU5F1 nuclear NANOG nuclear 1 TFPromoterBinding 16790525 POU5F1 nuclear NANOG nuclear 1 TFPromoterBinding 16978048 POU5F1 nuclear POU5F1 nuclear 1 TFPromoterBinding 16978048 POU5F1 nuclear POU5F1 nuclear 1 TFPromoterBinding 17324942 POU5F1 nuclear SOX2 nuclear 1 TFPromoterBinding 16978048 POU5F1 nuclear SOX2 nuclear 1 TFPromoterBinding 17324942 POU5F1 nuclear TSIX nuclear 1 TFPromoterBinding 19536159 POU5F1 nuclear UTF1 nuclear 1 TFPromoterBinding 17324942 POU5F1 nuclear XIST nuclear 1 TFPromoterBinding 19536159 POU5F1 nuclear YY1 nuclear 0 ProteinProtein 19536159 POU5F1 nuclear ZFP57 nuclear 1 TFPromoterBinding 15845352 POU5F1 nuclear ZSCAN10 nuclear 1 TFPromoterBinding 17344211 PRKCA cytosol AKT1 cytosol -1 SignalTransduction 16987252 PRKCA cytosol GLI1 nuclear 1 IndirectTranscription 17901397 PRKCA cytosol GSK3B cytosol -1 SignalTransduction 16987252 PRKCA cytosol NFKB1 nuclear 1 Indirectsignal 17901397 RING1 nuclear HIST2H3C nuclear -1 Ubiquitination 18037880 RNF2 nuclear HIST2H3C nuclear -1 Ubiquitination 18493325 SALL1 nuclear SALL4 nuclear 0 ProteinProtein 16790473 SALL4 nuclear ESRRB nuclear 1 TFPromoterBinding 17940043 SALL4 nuclear HDAC1 nuclear 0 ProteinProtein 19440552 SALL4 nuclear HDAC2 nuclear 0 ProteinProtein 19440552 SALL4 nuclear MTA1 nuclear 0 ProteinProtein 19440552 SALL4 nuclear MTA2 nuclear 0 ProteinProtein 19440552 SALL4 nuclear NANOG nuclear 1 ProteinProtein/TFPromterBinding 16840789 SALL4 nuclear NR5A2 nuclear 1 TFPromoterBinding 17940043 SALL4 nuclear OTX2 nuclear 1 TFPromoterBinding 17940043 SALL4 nuclear POU5F1 nuclear 1 TFPromoterBinding 17940043 SALL4 nuclear PTEN cytosol -1 TFPromoterBinding 19440552 SALL4 nuclear RBBP4 nuclear 0 ProteinProtein 19440552 SALL4 nuclear RBBP7 nuclear 0 ProteinProtein 19440552 SALL4 nuclear SALL1 nuclear -1 TFPromoterBinding 19440552 SALL4 nuclear SALL4 nuclear 1 TFPromoterBinding 17940043 SOX15 nuclear CTGF extra 1 IndirectTranscription 15863505 SOX15 nuclear HRC SR 1 TFPromoterBinding 15863505 SOX15 nuclear LEFTY2 extra 1 IndirectTranscription 15863505 SOX15 nuclear OTX2 nuclear 1 IndirectTranscription 15863505 SOX15 nuclear POU5F1 nuclear 0 ProteinProtein 15863505 SOX2 nuclear FBXO15 nuclear 1 TFPromoterBinding 12665572 SOX2 nuclear FGF4 extra 1 TFPromoterBinding 14659890 SOX2 nuclear LEFTY1 extra 1 TFPromoterBinding 17324942 SOX2 nuclear NANOG nuclear 1 TFPromoterBinding 15860457 SOX2 nuclear NANOG nuclear 1 TFPromoterBinding 16978048 SOX2 nuclear POU5F1 nuclear 0 ProteinProtein 15863505 SOX2 nuclear POU5F1 nuclear 0 ProteinProtein 16978048 SOX2 nuclear POU5F1 nuclear 1 TFPromoterBinding 16978048 SOX2 nuclear POU5F1 nuclear 0 ProteinProtein 17324942 SOX2 nuclear SOX2 nuclear 1 TFPromoterBinding 16978048 SOX2 nuclear SOX2 nuclear 1 TFPromoterBinding 17324942 SOX2 nuclear UTF1 nuclear 1 TFPromoterBinding 17324942 SOX2 nuclear XIST nuclear 1 TFPromoterBinding 19536159 SOX2 nuclear ZSCAN10 nuclear 1 TFPromoterBinding 17344211 SSH1 extra CALCIUM cytosol 1 Indirectsignal 17901397 SSH1 extra EGFR membrane 1 Indirectsignal 17901397 SSH1 extra FZD1 membrane -1 LigandProtein 17901397 SSH1 extra GLI1 nuclear 1 IndirectTranscription 17901397 SSH1 extra PRKCA cytosol 1 Indirectsignal 17901397 STAT3 nuclear CD9 membrane 1 Indirecttranscription 11950938 STAT3 nuclear CNNM1 nuclear 1 TFPromoterBinding 19544440 STAT3 nuclear DACT1 nuclear 1 TFPromoterBinding 19544440 STAT3 nuclear EED nuclear 1 TFPromoterBinding 18201968 STAT3 nuclear GABPA nuclear 1 indirecttranscription 17194449 STAT3 nuclear GBX2 nuclear 1 TFPromoterBinding 19544440 STAT3 nuclear ICAM1 membrane 1 TFPromoterBinding 19544440 STAT3 nuclear Ier3 membrane 1 TFPromoterBinding 19544440 STAT3 nuclear KDM3A nuclear 1 TFPromoterBinding 16988490 STAT3 nuclear KLF4 nuclear 1 IndirectTranscription 19571885 STAT3 nuclear KLF5 nuclear 1 TFPromoterBinding 19544440 STAT3 nuclear NANOG nuclear 1 TFPromoterBinding 16801560 STAT3 nuclear PIM1 nuclear 1 TFPromoterBinding 19544440 STAT3 nuclear PIM3 nuclear 1 TFPromoterBinding 19544440 STAT3 nuclear SGK nuclear 1 TFPromoterBinding 19544440 STAT3 nuclear SMAD7 nuclear 1 TFPromoterBinding 19544440 STAT3 nuclear SPRY2 cytosol 1 TFPromoterBinding 19544440 STAT3 nuclear STAT3 nuclear 1 TFPromoterBinding 19544440 STAT3 nuclear ZFP57 nuclear 1 TFPromoterBinding 15845352 SUMO1 cytosol POU5F1 nuclear -1 Posttranslational 17496161 T nuclear NANOG nuclear 1 TFPromoterBinding 16801560 TBX3 nuclear NANOG nuclear 1 TFPromoterBinding 19571885 TCF3 nuclear NANOG nuclear -1 TFPromoterBinding 16894029 TCL1 cytosol AKT1 cytosol 1 Phosphorylation 18983969 THAP11 nuclear HCFC1 nuclear 0 ProteinProtein 18585351 TIP60-P400 nuclear HIST4H4 nuclear 0 Acetylation 18614019 TIP60-P400 nuclear HIST3H3 nuclear 0 Acetylation 18948739 TPO extra MPL membrane 1 LigandProtein 12372629 TPO extra STAT3 nuclear 1 IndirectSignal 12372629 TRIM28 nuclear CBX1 nuclear 0 ProteinProtein 1769609 ZCCHC11 cytosol pre-let7 cytosol -1 Uridylation 19703396 ZNF143 nuclear NANOG nuclear 1 TFPromoterBinding 18687992 ZNF143 nuclear POU5F1 nuclear 0 ProteinProtein 18687992 ZSCAN10 nuclear POU5F1 nuclear 0 ProteinProtein 19740739 ZSCAN10 nuclear POU5F1 nuclear 1 TFPromoterBinding 19740739 ZSCAN10 nuclear SOX2 nuclear 0 ProteinProtein 19740739 NACC1 nuclear ARI3A nuclear 0 ProteinProtein 17093407 NACC1 nuclear ARID3B nuclear 0 ProteinProtein 17093407 NACC1 nuclear NACC1 nuclear 0 ProteinProtein 17093407 NACC1 nuclear NACC2 nuclear 0 ProteinProtein 17093407 NACC1 nuclear POU5F1 nuclear 0 ProteinProtein 17093407 NACC1 nuclear SALL1 nuclear 0 ProteinProtein 17093407 NACC1 nuclear SALL4 nuclear 0 ProteinProtein 17093407 NACC1 nuclear SHC1 nuclear 0 ProteinProtein 17093407 NACC1 nuclear SMARCC1 nuclear 0 ProteinProtein 17093407 NACC1 nuclear WDR18 nuclear 0 ProteinProtein 17093407 NACC1 nuclear ZNF281 nuclear 0 ProteinProtein 17093407 NANOG nuclear AHCTF1 nuclear 0 ProteinProtein 17093407 NANOG nuclear ESRRB nuclear 0 ProteinProtein 17093407 NANOG nuclear HDAC2 nuclear 0 ProteinProtein 17093407 NANOG nuclear ILF2 nuclear 0 ProteinProtein 17093407 NANOG nuclear MYBBP nuclear 0 ProteinProtein 17093407 NANOG nuclear NACC1 nuclear 0 ProteinProtein 17093407 NANOG nuclear NR0B1 nuclear 0 ProteinProtein 17093407 NANOG nuclear POU5F1 nuclear 0 ProteinProtein 17093407 NANOG nuclear REST nuclear 0 ProteinProtein 17093407 NANOG nuclear RIF1 nuclear 0 ProteinProtein 17093407 NANOG nuclear SALL1 nuclear 0 ProteinProtein 17093407 NANOG nuclear SALL4 nuclear 0 ProteinProtein 17093407 NANOG nuclear SP1 nuclear 0 ProteinProtein 17093407 NANOG nuclear TRIM28 nuclear 0 ProteinProtein 17093407 NANOG nuclear WAPAL nuclear 0 ProteinProtein 17093407 NANOG nuclear ZMYM2 nuclear 0 ProteinProtein 17093407 NANOG nuclear ZNF281 nuclear 0 ProteinProtein 17093407 NR0B1 nuclear ESRRB nuclear 0 ProteinProtein 17093407 NR0B1 nuclear NR0B1 nuclear 0 ProteinProtein 17093407 NR0B1 nuclear PELO nuclear 0 ProteinProtein 17093407 NR0B1 nuclear REST nuclear 0 ProteinProtein 17093407 NR0B1 nuclear SALL4 nuclear 0 ProteinProtein 17093407 NR0B1 nuclear SP1 nuclear 0 ProteinProtein 17093407 NR0B1 nuclear TRIM28 nuclear 0 ProteinProtein 17093407 NR0B1 nuclear ZNF609 nuclear 0 ProteinProtein 17093407 POU5F1 nuclear ARID3B nuclear 0 ProteinProtein 17093407 POU5F1 nuclear CDC2 nuclear 0 ProteinProtein 17093407 POU5F1 nuclear DPF2 nuclear 0 ProteinProtein 17093407 POU5F1 nuclear EWSR1 nuclear 0 ProteinProtein 17093407 POU5F1 nuclear EWSR1 nuclear 0 ProteinProtein 17093407 POU5F1 nuclear HDAC2 nuclear 0 ProteinProtein 17093407 POU5F1 nuclear ILF2 nuclear 0 ProteinProtein 17093407 POU5F1 nuclear POU5F1 nuclear 0 ProteinProtein 17093407 POU5F1 nuclear RYBP nuclear 0 ProteinProtein 17093407 POU5F1 nuclear SALL4 nuclear 0 ProteinProtein 17093407 POU5F1 nuclear SHC1 nuclear 0 ProteinProtein 17093407 POU5F1 nuclear SP1 nuclear 0 ProteinProtein 17093407 POU5F1 nuclear ZNF219 nuclear 0 ProteinProtein 17093407 REXO1 nuclear LGI1 nuclear 0 ProteinProtein 17093407 REXO1 nuclear NACC1 nuclear 0 ProteinProtein 17093407 REXO1 nuclear POU5F1 nuclear 0 ProteinProtein 17093407 ZNF281 nuclear CDC2 nuclear 0 ProteinProtein 17093407 ZNF281 nuclear DPF2 nuclear 0 ProteinProtein 17093407 ZNF281 nuclear EWSR1 nuclear 0 ProteinProtein 17093407 ZNF281 nuclear SALL4 nuclear 0 ProteinProtein 17093407 ZNF281 nuclear ZNF281 nuclear 0 ProteinProtein 17093407