Name

ZNF384 Gene

zinc finger protein 384

This gene encodes a C2H2-type zinc finger protein, which may function as a transcription factor. This gene also contains long CAG trinucleotide repeats that encode consecutive glutamine residues. The protein appears to bind and regulate the promoters of the extracellular matrix genes MMP1, MMP3, MMP7 and COL1A1. Studies in mouse suggest that nuclear matrix transcription factors (NP/NMP4) may be part of a general mechanical pathway that couples cell construction and function during extracellular matrix remodeling. Alternative splicing results in multiple transcript variants. Recurrent rearrangements of this gene with the Ewing's sarcoma gene, EWSR1 on chromosome 22, or with the TAF15 gene on chromosome 17, or with the TCF3 (E2A) gene on chromosome 19, have been observed in acute leukemia. A related pseudogene has been identified on chromosome 7. [provided by RefSeq, Apr 2011]

ZNF384 Gene Set

From ENCODE Transcription Factor Targets

target genes of the ZNF384 transcription factor in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.

ZNF384 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for ZNF384 from the Pathway Commons Protein-Protein Interactions dataset.

ZNF384_ES-E14_mm9_1 Gene Set

From ENCODE Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the ZNF384_ES-E14_mm9_1 transcription factor binding site profile from the ENCODE Transcription Factor Binding Site Profiles dataset.

ZNF384_GM12878_hg19_1 Gene Set

From ENCODE Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the ZNF384_GM12878_hg19_1 transcription factor binding site profile from the ENCODE Transcription Factor Binding Site Profiles dataset.

ZNF384_K562_hg19_1 Gene Set

From ENCODE Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the ZNF384_K562_hg19_1 transcription factor binding site profile from the ENCODE Transcription Factor Binding Site Profiles dataset.

ZNF384_CH12.LX_mm9_1 Gene Set

From ENCODE Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the ZNF384_CH12.LX_mm9_1 transcription factor binding site profile from the ENCODE Transcription Factor Binding Site Profiles dataset.

ZNF384_MEL cell line_mm9_1 Gene Set

From ENCODE Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the ZNF384_MEL cell line_mm9_1 transcription factor binding site profile from the ENCODE Transcription Factor Binding Site Profiles dataset.