Name

ZFX Gene

zinc finger protein, X-linked

This gene on the X chromosome is structurally similar to a related gene on the Y chromosome. It encodes a member of the krueppel C2H2-type zinc-finger protein family. The full-length protein contains an acidic transcriptional activation domain (AD), a nuclear localization sequence (NLS) and a DNA binding domain (DBD) consisting of 13 C2H2-type zinc fingers. Studies in mouse embryonic and adult hematopoietic stem cells showed that this gene was required as a transcriptional regulator for self-renewal of both stem cell types, but it was dispensable for growth and differentiation of their progeny. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2010]

ZFX-AS1 Gene

ZFX antisense RNA 1

ZFX Gene Set

From CHEA Transcription Factor Targets

target genes of the ZFX transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.

zfx Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term zfx in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

ZFX Gene Set

From JASPAR Predicted Transcription Factor Targets

target genes of the ZFX transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.

ZFX Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for ZFX from the Pathway Commons Protein-Protein Interactions dataset.

ZFX-18555785-MESC-mouse Gene Set

From CHEA Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the ZFX-18555785-MESC-mouse transcription factor binding site profile from the CHEA Transcription Factor Binding Site Profiles dataset.

ZFX_KD_GSE43021_130_human_NOMO1 Gene Set

From GEO Signatures of Differentially Expressed Genes for Gene Perturbations

genes differentially expressed following the ZFX_KD_GSE43021_130_human_NOMO1 gene perturbation from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

ZFX_KO_GDS2718_151_mouse_hematopoietic stem cells Gene Set

From GEO Signatures of Differentially Expressed Genes for Gene Perturbations

genes differentially expressed following the ZFX_KO_GDS2718_151_mouse_hematopoietic stem cells gene perturbation from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

ZFX_KO_GDS2718_150_mouse_embryonic stem cells Gene Set

From GEO Signatures of Differentially Expressed Genes for Gene Perturbations

genes differentially expressed following the ZFX_KO_GDS2718_150_mouse_embryonic stem cells gene perturbation from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

zfx_17448993_embryonic_stem_cell_lof_mouse_gpl1261_gds2718 Gene Set

From GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations

genes differentially expressed following the zfx_17448993_embryonic_stem_cell_lof_mouse_gpl1261_gds2718 transcription factor perturbation from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.

Transcriptional activator, Zfx / Zfy domain Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Transcriptional activator, Zfx / Zfy domain protein domain from the InterPro Predicted Protein Domain Annotations dataset.