Name

TP63 Gene

tumor protein p63

This gene encodes a member of the p53 family of transcription factors. An animal model, p63 -/- mice, has been useful in defining the role this protein plays in the development and maintenance of stratified epithelial tissues. p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammary syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8. Both alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different proteins. Many transcripts encoding different proteins have been reported but the biological validity and the full-length nature of these variants have not been determined. [provided by RefSeq, Jul 2008]

TP63 Gene Set

From CHEA Transcription Factor Targets

target genes of the TP63 transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.

tp63 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term tp63 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

TP63 Gene Set

From JASPAR Predicted Transcription Factor Targets

target genes of the TP63 transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.

TP63 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for TP63 from the Pathway Commons Protein-Protein Interactions dataset.

TP63-23658742-EP156T-HUMAN Gene Set

From CHEA Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the TP63-23658742-EP156T-HUMAN transcription factor binding site profile from the CHEA Transcription Factor Binding Site Profiles dataset.

TP63-17297297-HaCaT-human Gene Set

From CHEA Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the TP63-17297297-HaCaT-human transcription factor binding site profile from the CHEA Transcription Factor Binding Site Profiles dataset.

TP63-19390658-HaCaT-human Gene Set

From CHEA Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the TP63-19390658-HaCaT-human transcription factor binding site profile from the CHEA Transcription Factor Binding Site Profiles dataset.

TP63-22573176-HFKS-HUMAN Gene Set

From CHEA Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the TP63-22573176-HFKS-HUMAN transcription factor binding site profile from the CHEA Transcription Factor Binding Site Profiles dataset.

TP63_NULL MUTATION_GDS1434_308_mouse_Skin at embryonic age E18.5 Gene Set

From GEO Signatures of Differentially Expressed Genes for Gene Perturbations

genes differentially expressed following the TP63_NULL MUTATION_GDS1434_308_mouse_Skin at embryonic age E18.5 gene perturbation from the GEO Signatures of Differentially Expressed Genes for Gene Perturbations dataset.

tp63_16885358_squamous_epithelia_lof_human_gpl570_gds2088 Gene Set

From GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations

genes differentially expressed following the tp63_16885358_squamous_epithelia_lof_human_gpl570_gds2088 transcription factor perturbation from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.