Name

SURF1 Gene

surfeit 1

This gene encodes a protein localized to the inner mitochondrial membrane and thought to be involved in the biogenesis of the cytochrome c oxidase complex. The protein is a member of the SURF1 family, which includes the related yeast protein SHY1 and rickettsial protein RP733. The gene is located in the surfeit gene cluster, a group of very tightly linked genes that do not share sequence similarity, where it shares a bidirectional promoter with SURF2 on the opposite strand. Defects in this gene are a cause of Leigh syndrome, a severe neurological disorder that is commonly associated with systemic cytochrome c oxidase deficiency. [provided by RefSeq, Jul 2008]

surf1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term surf1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

SURF1 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for SURF1 from the Pathway Commons Protein-Protein Interactions dataset.