Name

SPAG1 Gene

sperm associated antigen 1

The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm agglutinating antibodies from an infertile woman. Furthermore, immunization of female rats with the recombinant human protein reduced fertility. This protein localizes to the plasma membrane of germ cells in the testis and to the post-acrosomal plasma membrane of mature spermatozoa. Recombinant polypeptide binds GTP and exhibits GTPase activity. Thus, this protein may regulate GTP signal transduction pathways involved in spermatogenesis and fertilization. Two transcript variants of this gene encode the same protein. [provided by RefSeq, Jul 2008]

SPAG11B Gene

sperm associated antigen 11B

This gene encodes several androgen-dependent, epididymis-specific secretory proteins. The specific functions of these proteins have not been determined, but they are thought to be involved in sperm maturation. Some of the isoforms contain regions of similarity to beta-defensins, a family of antimicrobial peptides. The gene is located on chromosome 8p23 near the defensin gene cluster. Alternative splicing of this gene results in seven transcript variants encoding different isoforms. Two different N-terminal and five different C-terminal protein sequences are encoded by the splice variants. Two additional variants have been described, but their full length sequences have not been determined. [provided by RefSeq, Jul 2008]

SPAG11A Gene

sperm associated antigen 11A

SPAG16 Gene

sperm associated antigen 16

Cilia and flagella are comprised of a microtubular backbone, the axoneme, which is organized by the basal body and surrounded by plasma membrane. SPAG16 encodes 2 major proteins that associate with the axoneme of sperm tail and the nucleus of postmeiotic germ cells, respectively (Zhang et al., 2007 [PubMed 17699735]).[supplied by OMIM, Jul 2008]

SPAG17 Gene

sperm associated antigen 17

spag1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term spag1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

SPAG1 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for SPAG1 from the Pathway Commons Protein-Protein Interactions dataset.

spag11bd Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term spag11bd in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

spag11b Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term spag11b in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

SPAG17 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for SPAG17 from the Pathway Commons Protein-Protein Interactions dataset.

SPAG11B Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for SPAG11B from the Pathway Commons Protein-Protein Interactions dataset.

SPAG16 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for SPAG16 from the Pathway Commons Protein-Protein Interactions dataset.