Name

SLX4 Gene

SLX4 structure-specific endonuclease subunit

This gene encodes a structure-specific endonuclease subunit. The encoded protein contains a central BTB domain and it forms a multiprotein complex with the ERCC4(XPF)-ERCC1, MUS81-EME1, and SLX1 endonucleases, and also associates with MSH2/MSH3 mismatch repair complex, telomere binding complex TERF2(TRF2)-TERF2IP(RAP1), the protein kinase PLK1 and the uncharacterized protein C20orf94. The multiprotein complex is required for repair of specific types of DNA lesions and is critical for cellular responses to replication fork failure. The encoded protein acts as a docking platform for the assembly of multiple structure-specific endonucleases.[provided by RefSeq, Jan 2011]

SLX4IP Gene

SLX4 interacting protein

slx4 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term slx4 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

SLX4 Gene Set

From NURSA Protein-Protein Interactions

interacting proteins for SLX4 from the NURSA Protein-Protein Interactions dataset.

SLX4 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for SLX4 from the Pathway Commons Protein-Protein Interactions dataset.

slx1-slx4 complex Gene Set

From COMPARTMENTS Curated Protein Localization Evidence Scores

proteins localized to the slx1-slx4 complex cellular component from the COMPARTMENTS Curated Protein Localization Evidence Scores dataset.

slx1-slx4 complex Gene Set

From COMPARTMENTS Text-mining Protein Localization Evidence Scores

proteins co-occuring with the slx1-slx4 complex cellular component in abstracts of biomedical publications from the COMPARTMENTS Text-mining Protein Localization Evidence Scores dataset.

slx4associated Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term slx4associated in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

slx1-slx4 complex Gene Set

From GO Cellular Component Annotations

proteins localized to the slx1-slx4 complex cellular component from the curated GO Cellular Component Annotations dataset.

Structure-specific endonuclease subunit Slx4 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the Structure-specific endonuclease subunit Slx4 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

SLX4IP Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for SLX4IP from the Pathway Commons Protein-Protein Interactions dataset.