Name

SIRT5 Gene

sirtuin 5

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class III of the sirtuin family. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2010]

sirt5 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term sirt5 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

SIRT5 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for SIRT5 from the Pathway Commons Protein-Protein Interactions dataset.

sirt5dependent Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term sirt5dependent in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.