serpin peptidase inhibitor, clade B (ovalbumin), member 6

The protein encoded by this gene is a member of the serpin (serine proteinase inhibitor) superfamily, and ovalbumin(ov)-serpin subfamily. It was originally discovered as a placental thrombin inhibitor. The mouse homolog was found to be expressed in the hair cells of the inner ear. Mutations in this gene are associated with nonsyndromic progressive hearing loss, suggesting that this serpin plays an important role in the inner ear in the protection against leakage of lysosomal content during stress, and that loss of this protection results in cell death and sensorineural hearing loss. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2010]

serpinb6 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term serpinb6 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.


From Pathway Commons Protein-Protein Interactions

interacting proteins for SERPINB6 from the Pathway Commons Protein-Protein Interactions dataset.