Name

SDCBP Gene

syndecan binding protein (syntenin)

The protein encoded by this gene was initially identified as a molecule linking syndecan-mediated signaling to the cytoskeleton. The syntenin protein contains tandemly repeated PDZ domains that bind the cytoplasmic, C-terminal domains of a variety of transmembrane proteins. This protein may also affect cytoskeletal-membrane organization, cell adhesion, protein trafficking, and the activation of transcription factors. The protein is primarily localized to membrane-associated adherens junctions and focal adhesions but is also found at the endoplasmic reticulum and nucleus. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

SDCBP2-AS1 Gene

SDCBP2 antisense RNA 1

SDCBPP1 Gene

syndecan binding protein (syntenin) pseudogene 1

SDCBPP2 Gene

syndecan binding protein (syntenin) pseudogene 2

FKBP1A-SDCBP2 Gene

FKBP1A-SDCBP2 readthrough (NMD candidate)

This locus represents naturally occurring read-through transcription between the neighboring FK506 binding protein 1A, 12kDa and syndecan binding protein (syntenin) 2 genes on chromosome 20. The read-through transcript is a candidate for nonsense-mediated mRNA decay (NMD), and is unlikely to produce a protein product. [provided by RefSeq, Dec 2010]

SDCBPP3 Gene

syndecan binding protein (syntenin) pseudogene 3

SDCBP2 Gene

syndecan binding protein (syntenin) 2

The protein encoded by this gene contains two class II PDZ domains. PDZ domains facilitate protein-protein interactions by binding to the cytoplasmic C-terminus of transmembrane proteins, and PDZ-containing proteins mediate cell signaling and the organization of protein complexes. The encoded protein binds to phosphatidylinositol 4, 5-bisphosphate (PIP2) and plays a role in nuclear PIP2 organization and cell division. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. Read-through transcription also exists between this gene and the upstream FKBP1A (FK506 binding protein 1A, 12kDa) gene, as represented in GeneID:100528031. [provided by RefSeq, Sep 2011]

SDCBP Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for SDCBP from the Pathway Commons Protein-Protein Interactions dataset.

SDCBP2 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for SDCBP2 from the Pathway Commons Protein-Protein Interactions dataset.