Name

RTN3 Gene

reticulon 3

This gene belongs to the reticulon family of highly conserved genes that are preferentially expressed in neuroendocrine tissues. This family of proteins interact with, and modulate the activity of beta-amyloid converting enzyme 1 (BACE1), and the production of amyloid-beta. An increase in the expression of any reticulon protein substantially reduces the production of amyloid-beta, suggesting that reticulon proteins are negative modulators of BACE1 in cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, and pseudogenes of this gene are located on chromosomes 4 and 12. [provided by RefSeq, May 2012]

RTN3P1 Gene

reticulon 3 pseudogene 1

rtn3 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term rtn3 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

RTN3 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for RTN3 from the Pathway Commons Protein-Protein Interactions dataset.

rtn3nogo Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term rtn3nogo in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.