Name

PTPRE Gene

protein tyrosine phosphatase, receptor type, E

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Two alternatively spliced transcript variants of this gene have been reported, one of which encodes a receptor-type PTP that possesses a short extracellular domain, a single transmembrane region, and two tandem intracytoplasmic catalytic domains; Another one encodes a PTP that contains a distinct hydrophilic N-terminus, and thus represents a nonreceptor-type isoform of this PTP. Studies of the similar gene in mice suggested the regulatory roles of this PTP in RAS related signal transduction pathways, cytokines induced SATA signaling, as well as the activation of voltage-gated K+ channels. [provided by RefSeq, Jul 2008]

PTPRE Gene Set

From DEPOD Substrates of Phosphatases

substrates of the phosphatase PTPRE from the curated DEPOD Substrates of Phosphatases dataset.

ptpre Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term ptpre in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

PTPRE Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for PTPRE from the Pathway Commons Protein-Protein Interactions dataset.