Name

PRSS1 Gene

protease, serine, 1 (trypsin 1)

This gene encodes a trypsinogen, which is a member of the trypsin family of serine proteases. This enzyme is secreted by the pancreas and cleaved to its active form in the small intestine. It is active on peptide linkages involving the carboxyl group of lysine or arginine. Mutations in this gene are associated with hereditary pancreatitis. This gene and several other trypsinogen genes are localized to the T cell receptor beta locus on chromosome 7. [provided by RefSeq, Jul 2008]

PRSS12 Gene

protease, serine, 12 (neurotrypsin, motopsin)

This gene encodes a member of the trypsin family of serine proteases. Studies in mouse suggest that the encoded enzyme may be involved in structural reorganizations associated with learning and memory. The enzyme is also expressed in Leydig cells in the testis, but its function in this tissue is unknown. Defects in this gene are a cause of mental retardation autosomal recessive type 1 (MRT1). [provided by RefSeq, Jul 2010]

PRSS16 Gene

protease, serine, 16 (thymus)

This gene encodes a serine protease expressed exclusively in the thymus. It is thought to play a role in the alternative antigen presenting pathway used by cortical thymic epithelial cells during the positive selection of T cells. The gene is found in the large histone gene cluster on chromosome 6, near the major histocompatibility complex (MHC) class I region. A second transcript variant has been described, but its full length nature has not been determined. [provided by RefSeq, Jul 2008]

prss1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term prss1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

PRSS1 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for PRSS1 from the Pathway Commons Protein-Protein Interactions dataset.

prss1prss2 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term prss1prss2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

prss16 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term prss16 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.