Name

POU5F1 Gene

POU class 5 homeobox 1

This gene encodes a transcription factor containing a POU homeodomain that plays a key role in embryonic development and stem cell pluripotency. Aberrant expression of this gene in adult tissues is associated with tumorigenesis. This gene can participate in a translocation with the Ewing's sarcoma gene on chromosome 21, which also leads to tumor formation. Alternative splicing, as well as usage of alternative AUG and non-AUG translation initiation codons, results in multiple isoforms. One of the AUG start codons is polymorphic in human populations. Related pseudogenes have been identified on chromosomes 1, 3, 8, 10, and 12. [provided by RefSeq, Oct 2013]

POU5F1B Gene

POU class 5 homeobox 1B

This intronless gene was thought to be a transcribed pseudogene of POU class 5 homeobox 1, however, it has been reported that this gene can encode a functional protein. The encoded protein is nearly the same length as and highly similar to the POU class 5 homeobox 1 transcription factor, has been shown to be a weak transcriptional activator and may play a role in carcinogenesis and eye development. [provided by RefSeq, Apr 2009]

POU5F1P2 Gene

POU class 5 homeobox 1 pseudogene 2

POU5F1P3 Gene

POU class 5 homeobox 1 pseudogene 3

POU5F1P4 Gene

POU class 5 homeobox 1 pseudogene 4

POU5F1P6 Gene

POU class 5 homeobox 1 pseudogene 6

POU5F1P7 Gene

POU class 5 homeobox 1 pseudogene 7

POU5F1P5 Gene

POU class 5 homeobox 1 pseudogene 5

POU5F1 Gene Set

From CHEA Transcription Factor Targets

target genes of the POU5F1 transcription factor in low- or high-throughput transcription factor functional studies from the CHEA Transcription Factor Targets dataset.

POU5F1 Gene Set

From ENCODE Transcription Factor Targets

target genes of the POU5F1 transcription factor in ChIP-seq datasets from the ENCODE Transcription Factor Targets dataset.

pou5f1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term pou5f1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

POU5F1 Gene Set

From JASPAR Predicted Transcription Factor Targets

target genes of the POU5F1 transcription factor predicted using known transcription factor binding site motifs from the JASPAR Predicted Transcription Factor Targets dataset.

POU5F1 Gene Set

From MotifMap Predicted Transcription Factor Targets

target genes of the POU5F1 transcription factor predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.

POU5F1 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for POU5F1 from the Pathway Commons Protein-Protein Interactions dataset.

POU5F1-18555785-MESC-mouse Gene Set

From CHEA Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the POU5F1-18555785-MESC-mouse transcription factor binding site profile from the CHEA Transcription Factor Binding Site Profiles dataset.

POU5F1-18358816-MESC-mouse Gene Set

From CHEA Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the POU5F1-18358816-MESC-mouse transcription factor binding site profile from the CHEA Transcription Factor Binding Site Profiles dataset.

POU5F1-18700969-MESC-mouse Gene Set

From CHEA Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the POU5F1-18700969-MESC-mouse transcription factor binding site profile from the CHEA Transcription Factor Binding Site Profiles dataset.

POU5F1-16153702-HESC-human Gene Set

From CHEA Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the POU5F1-16153702-HESC-human transcription factor binding site profile from the CHEA Transcription Factor Binding Site Profiles dataset.

POU5F1-18692474-MESC-mouse Gene Set

From CHEA Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the POU5F1-18692474-MESC-mouse transcription factor binding site profile from the CHEA Transcription Factor Binding Site Profiles dataset.

POU5F1-18347094-MESC-mouse Gene Set

From CHEA Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the POU5F1-18347094-MESC-mouse transcription factor binding site profile from the CHEA Transcription Factor Binding Site Profiles dataset.

POU5F1-16518401-MESC-mouse Gene Set

From CHEA Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the POU5F1-16518401-MESC-mouse transcription factor binding site profile from the CHEA Transcription Factor Binding Site Profiles dataset.

POU5F1_H1-hESC_hg19_1 Gene Set

From ENCODE Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the POU5F1_H1-hESC_hg19_1 transcription factor binding site profile from the ENCODE Transcription Factor Binding Site Profiles dataset.

POU5F1_H1-hESC_hg19_2 Gene Set

From ENCODE Transcription Factor Binding Site Profiles

genes with transcription factor binding evidence in the POU5F1_H1-hESC_hg19_2 transcription factor binding site profile from the ENCODE Transcription Factor Binding Site Profiles dataset.

pou5f1p1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term pou5f1p1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

pou5f1_20526341_human_embryonic_stem_cells_hesc_lof_human_gpl6947_gse21135 Gene Set

From GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations

genes differentially expressed following the pou5f1_20526341_human_embryonic_stem_cells_hesc_lof_human_gpl6947_gse21135 transcription factor perturbation from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.

pou5f1_16518401_mesc_lof_mouse_gpl1261_gds1824 Gene Set

From GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations

genes differentially expressed following the pou5f1_16518401_mesc_lof_mouse_gpl1261_gds1824 transcription factor perturbation from the GEO Signatures of Differentially Expressed Genes for Transcription Factor Perturbations dataset.

POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation Gene Set

From Reactome Pathways

proteins participating in the POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation pathway from the Reactome Pathways dataset.

POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation Gene Set

From Reactome Pathways

proteins participating in the POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation pathway from the Reactome Pathways dataset.