Name

PORCN Gene

porcupine homolog (Drosophila)

This gene belongs to the evolutionarily conserved porcupine (Porc) gene family. Genes of the porcupine family encode endoplasmic reticulum proteins with multiple transmembrane domains. Porcupine proteins are involved in the processing of Wnt (wingless and int homologue) proteins. Disruption of this gene is associated with focal dermal hypoplasia, and the encoded protein has been implicated in cancer. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Aug 2013]

PORCN Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for PORCN from the Pathway Commons Protein-Protein Interactions dataset.

WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 Gene Set

From Reactome Pathways

proteins participating in the WNT ligand secretion is abrogated by the PORCN inhibitor LGK974 pathway from the Reactome Pathways dataset.