Name

PON2 Gene

paraoxonase 2

This gene encodes a member of the paraoxonase gene family, which includes three known members located adjacent to each other on the long arm of chromosome 7. The encoded protein is ubiquitously expressed in human tissues, membrane-bound, and may act as a cellular antioxidant, protecting cells from oxidative stress. Hydrolytic activity against acylhomoserine lactones, important bacterial quorum-sensing mediators, suggests the encoded protein may also play a role in defense responses to pathogenic bacteria. Mutations in this gene may be associated with vascular disease and a number of quantitative phenotypes related to diabetes. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

pon2 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term pon2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

PON2 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for PON2 from the Pathway Commons Protein-Protein Interactions dataset.

pon2s Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term pon2s in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.