Name

PFKFB2 Gene

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2

The protein encoded by this gene is involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate, and a fructose-2,6-biphosphatase activity that catalyzes the degradation of fructose-2,6-bisphosphate. This protein regulates fructose-2,6-bisphosphate levels in the heart, while a related enzyme encoded by a different gene regulates fructose-2,6-bisphosphate levels in the liver and muscle. This enzyme functions as a homodimer. Two transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

pfkfb2 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term pfkfb2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

PFKFB2 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for PFKFB2 from the Pathway Commons Protein-Protein Interactions dataset.