Name

NR1H2 Gene

nuclear receptor subfamily 1, group H, member 2

The liver X receptors, LXRA (NR1H3; MIM 602423) and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs; see MIM 180245) and regulate expression of target genes containing LXR response elements (summary by Korf et al., 2009 [PubMed 19436111]).[supplied by OMIM, Jan 2010]

nr1h2 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term nr1h2 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

NR1H2 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for NR1H2 from the Pathway Commons Protein-Protein Interactions dataset.

NR1H2 Gene Set

From TRANSFAC Predicted Transcription Factor Targets

target genes of the NR1H2 transcription factor predicted using known transcription factor binding site motifs from the TRANSFAC Predicted Transcription Factor Targets dataset.

NR1H2::RXRA Gene Set

From MotifMap Predicted Transcription Factor Targets

target genes of the NR1H2::RXRA transcription factor predicted using known transcription factor binding site motifs from the MotifMap Predicted Transcription Factor Targets dataset.