Name

NOS1 Gene

nitric oxide synthase 1 (neuronal)

The protein encoded by this gene belongs to the family of nitric oxide synthases, which synthesize nitric oxide from L-arginine. Nitric oxide is a reactive free radical, which acts as a biologic mediator in several processes, including neurotransmission, and antimicrobial and antitumoral activities. In the brain and peripheral nervous system, nitric oxide displays many properties of a neurotransmitter, and has been implicated in neurotoxicity associated with stroke and neurodegenerative diseases, neural regulation of smooth muscle, including peristalsis, and penile erection. This protein is ubiquitously expressed, with high level of expression in skeletal muscle. Multiple transcript variants that differ in the 5' UTR have been described for this gene but the full-length nature of these transcripts is not known. Additionally, alternatively spliced transcript variants encoding different isoforms (some testis-specific) have been found for this gene.[provided by RefSeq, Feb 2011]

NOS1AP Gene

nitric oxide synthase 1 (neuronal) adaptor protein

This gene encodes a cytosolic protein that binds to the signaling molecule, neuronal nitric oxide synthase (nNOS). This protein has a C-terminal PDZ-binding domain that mediates interactions with nNOS and an N-terminal phosphotyrosine binding (PTB) domain that binds to the small monomeric G protein, Dexras1. Studies of the related mouse and rat proteins have shown that this protein functions as an adapter protein linking nNOS to specific targets, such as Dexras1 and the synapsins. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2009]

nos1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term nos1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

NOS1 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for NOS1 from the Pathway Commons Protein-Protein Interactions dataset.

neuronal no synthase (nos1) gene polymorphism Gene Set

From GAD Gene-Disease Associations

genes associated with the disease neuronal no synthase (nos1) gene polymorphism in GWAS and other genetic association datasets from the GAD Gene-Disease Associations dataset.

nos1ap Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term nos1ap in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

NOS1AP Gene Set

From NURSA Protein-Protein Interactions

interacting proteins for NOS1AP from the NURSA Protein-Protein Interactions dataset.

NOS1AP Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for NOS1AP from the Pathway Commons Protein-Protein Interactions dataset.