Name

NBR1 Gene

neighbor of BRCA1 gene 1

The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled-coil motif, which is present in many genes with transformation potential. It functions as a specific autophagy receptor for the selective autophagic degradation of peroxisomes by forming intracellular inclusions with ubiquitylated autophagic substrates. This gene is located on a region of chromosome 17q21.1 that is in close proximity to the BRCA1 tumor suppressor gene. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]

nbr1 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term nbr1 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

NBR1 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for NBR1 from the Pathway Commons Protein-Protein Interactions dataset.