Name

MDM4 Gene

MDM4, p53 regulator

This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011]

mdm4 Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term mdm4 in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

MDM4 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the MDM4 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

MDM4 Gene Set

From Pathway Commons Protein-Protein Interactions

interacting proteins for MDM4 from the Pathway Commons Protein-Protein Interactions dataset.

mdm4mediated Gene Set

From GeneRIF Biological Term Annotations

genes co-occuring with the biological term mdm4mediated in literature-supported statements describing functions of genes from the GeneRIF Biological Term Annotations dataset.

mdm2/mdm4 family protein binding Gene Set

From GO Molecular Function Annotations

genes performing the mdm2/mdm4 family protein binding molecular function from the curated GO Molecular Function Annotations dataset.

p53 negative regulator Mdm2/Mdm4 Gene Set

From InterPro Predicted Protein Domain Annotations

proteins predicted to have the p53 negative regulator Mdm2/Mdm4 protein domain from the InterPro Predicted Protein Domain Annotations dataset.

BL1258 (MDM4) Gene Set

From NURSA Protein Complexes

proteins in the BL1258 (MDM4) protein complex recovered by IP-MS from the NURSA Protein Complexes dataset.